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Toshiro Sato

Toshiro Sato

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
43903
World Ranking
6105
National Ranking
391

Overview

Toshiro Sato is affiliated with Keio University in Japan and has a significant body of research primarily focused on medicine and biochemistry, genetics, and molecular biology. Their academic contributions span topics related to oncology, molecular biology, infectious diseases, genetics, and surgery.

The scientist's recent publications reflect an emphasis on cancer research, particularly related to colorectal polyps, organoids, and the cellular microenvironment. Some of the recent papers include:

  • Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps, 2021, Cell
  • Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids, 2021, Cell Stem Cell
  • An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping, 2020, Cell
  • Cell-matrix interface regulates dormancy in human colon cancer stem cells, 2022, Nature
  • Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases, 2020, Nature Materials

The main fields of study for this researcher are medicine, with 139 publications, and biochemistry, genetics, and molecular biology, with 62 publications. Subfields include oncology (50 publications), molecular biology (23), infectious diseases (23), genetics (19), and surgery (13). The topics of work cover a broad range of areas including cancer cells and metastasis, digestive system and related health, COVID-19 clinical research studies, 3D printing in biomedical research, SARS-CoV-2 and COVID-19 research, genetic factors in colorectal cancer, and healthcare impacts of COVID-19.

  • Cancer Cells and Metastasis
  • Digestive system and related health
  • COVID-19 Clinical Research Studies
  • 3D Printing in Biomedical Research
  • SARS-CoV-2 and COVID-19 Research
  • Genetic factors in colorectal cancer
  • COVID-19 and healthcare impacts

Frequent co-authors in Toshiro Sato's research include Shinya Sugimoto, Takanori Kanai, Masayuki Fujii, Mami Matano, and Toshiki Ebisudani. These collaborations suggest sustained partnerships in various aspects of biomedical research.

  • Shinya Sugimoto
  • Takanori Kanai
  • Masayuki Fujii
  • Mami Matano
  • Toshiki Ebisudani

Publications by Sato frequently appear in scholarly venues such as Gastroenterology, bioRxiv (Cold Spring Harbor Laboratory), Nature, Cell Reports, and OPAL (Open@LaTrobe) from La Trobe University.

  • Gastroenterology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cell Reports
  • OPAL (Open@LaTrobe) (La Trobe University)

Best Publications

  • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

    Toshiro Sato;Robert G J Vries;Hugo J. Snippert;Marc van de Wetering

  • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

    Toshiro Sato;Daniel E. Stange;Marc Ferrante;Marc Ferrante;Robert G.J. Vries

  • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

    Toshiro Sato;Johan H. van Es;Hugo J. Snippert;Daniel E. Stange

  • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

    Hugo J. Snippert;Laurens G. van der Flier;Toshiro Sato;Johan H. van Es

  • Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

    Nick Barker;Meritxell Huch;Pekka Kujala;Marc van de Wetering

  • In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

    Meritxell Huch;Craig Dorrell;Sylvia F. Boj;Johan H. van Es

  • Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

    Toshiro Sato;Hans Clevers

  • Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

    Mami Matano;Shoichi Date;Mariko Shimokawa;Ai Takano

  • Tissue-specific mutation accumulation in human adult stem cells during life

    Francis Blokzijl;Joep de Ligt;Myrthe Jager;Valentina Sasselli

  • Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 + stem cell

    Shiro Yui;Tetsuya Nakamura;Toshiro Sato;Toshiro Sato;Yasuhiro Nemoto

  • Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

    Johan H. van Es;Toshiro Sato;Marc van de Wetering;Anna Lyubimova

  • Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

    Nobuhiko Kamada;Tadakazu Hisamatsu;Susumu Okamoto;Hiroshi Chinen

  • Isolation and in vitro expansion of human colonic stem cells

    Peter Jung;Toshiro Sato;Toshiro Sato;Anna Merlos-Suárez;Francisco M Barriga

  • A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.

    Masayuki Fujii;Mariko Shimokawa;Shoichi Date;Ai Takano

  • Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

    Meritxell Huch;Paola Bonfanti;Sylvia F Boj;Toshiro Sato

  • Visualization and targeting of LGR5 + human colon cancer stem cells

    Mariko Shimokawa;Yuki Ohta;Shingo Nishikori;Mami Matano

  • PTEN-deficient intestinal stem cells initiate intestinal polyposis.

    Xi C He;Tong Yin;Justin C Grindley;Qiang Tian

  • Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

    Takashi Seino;Shintaro Kawasaki;Mariko Shimokawa;Hiroki Tamagawa

  • Current view: intestinal stem cells and signaling.

    David H. Scoville;Toshiro Sato;Xi C. He;Linheng Li;Linheng Li

  • Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

    Masayuki Fujii;Mami Matano;Kohta Toshimitsu;Ai Takano

Frequent Co-Authors

Takanori Kanai
Takanori Kanai Keio University
Toshifumi Hibi
Toshifumi Hibi Kitasato University
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Nobuhiko Kamada
Nobuhiko Kamada University of Michigan–Ann Arbor
Mamoru Watanabe
Mamoru Watanabe Tokyo Medical and Dental University
Johan H. van Es
Johan H. van Es Utrecht University
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Hiromasa Ishii
Hiromasa Ishii Keio University
Marc van de Wetering
Marc van de Wetering Royal Netherlands Academy of Arts and Sciences
Yuko Kitagawa
Yuko Kitagawa Keio University

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