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Biology and Biochemistry

D-Index
65
Citations
57818
World Ranking
8908
National Ranking
235

Overview

Johan H. van Es is affiliated with Utrecht University in the Netherlands. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Surgery, Oncology, Genetics, and Immunology.

The research topics explored by van Es include:

  • Digestive system and related health
  • CRISPR and Genetic Engineering
  • Pancreatic function and diabetes
  • Neonatal Respiratory Health Research
  • Cancer Cells and Metastasis
  • IL-33, ST2, and ILC Pathways
  • Pancreatic and Hepatic Oncology Research

Van Es has published frequently in several scientific venues, reflecting the breadth of their work. These venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell stem cell
  • Nature Communications
  • Science
  • The Journal of Cell Biology

Their recent notable papers include:

  • Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells, 2020, Cell stem cell
  • Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids, 2020, Nature Communications
  • The function of GORASPs in Golgi apparatus organization in vivo, 2020, The Journal of Cell Biology
  • One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids, 2023, Nature Communications
  • Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation, 2023, Science

Frequent collaborators in van Es's research include:

  • Hans Clevers
  • Harry Begthel
  • Jeroen Korving
  • Maarten H. Geurts
  • Peter J. Peters

This scientist has contributed extensively to the understanding of cellular and molecular mechanisms relevant to digestion, cancer, and genetic engineering technologies such as CRISPR. Their work has been published across high-impact journals and preprint platforms, indicating an active and ongoing engagement with cutting-edge biomedical research.

Best Publications

  • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

    Toshiro Sato;Robert G J Vries;Hugo J. Snippert;Marc van de Wetering

  • Identification of stem cells in small intestine and colon by marker gene Lgr5

    Nick Barker;Johan H. van Es;Jeroen Kuipers;Pekka Kujala

  • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

    Toshiro Sato;Daniel E. Stange;Marc Ferrante;Marc Ferrante;Robert G.J. Vries

  • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

    Toshiro Sato;Johan H. van Es;Hugo J. Snippert;Daniel E. Stange

  • Crypt stem cells as the cells-of-origin of intestinal cancer

    Nick Barker;Rachel A. Ridgway;Johan H. Van Es;Marc Van De Wetering

  • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

    Hugo J. Snippert;Laurens G. van der Flier;Toshiro Sato;Johan H. van Es

  • Caught up in a Wnt storm: Wnt signaling in cancer.

    Rachel H. Giles;Johan H. van Es;Hans Clevers

  • Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

    Johan H. van Es;Marielle E. van Gijn;Orbicia Riccio;Maaike van den Born

  • Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

    Nick Barker;Meritxell Huch;Pekka Kujala;Marc van de Wetering

  • In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

    Meritxell Huch;Craig Dorrell;Sylvia F. Boj;Johan H. van Es

  • Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

    Marc van de Wetering;Robert Cavallo;Dennis Dooijes;Moniek van Beest

  • Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

    Arnout G. Schepers;Hugo J. Snippert;Daniel E. Stange;Maaike van den Born

  • Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

    Viljar Jaks;Nick Barker;Maria Kasper;Johan H. van Es

  • Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

    Bon-Kyoung Koo;Maureen Spit;Ingrid Jordens;Teck Y. Low

  • Mutations in the APC tumour suppressor gene cause chromosomal instability

    Riccardo Fodde;Jeroen Kuipers;Jeroen Kuipers;Carla Rosenberg;Ron Smits

  • De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine

    Anna Pavlina G Haramis;Harry Begthel;Maaike Van Den Born;Johan Van Es

  • Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

    Johan H. van Es;Toshiro Sato;Marc van de Wetering;Anna Lyubimova

  • The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

    Javier Muñoz;Daniel E Stange;Arnout G Schepers;Marc van de Wetering

  • Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

    Laurens G van der Flier;Marielle E van Gijn;Pantelis Hatzis;Pekka Kujala

  • Wnt signalling induces maturation of Paneth cells in intestinal crypts

    Johan H. van Es;Philippe Jay;Alex Gregorieff;Marielle E. van Gijn

Frequent Co-Authors

Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Marc van de Wetering
Marc van de Wetering Royal Netherlands Academy of Arts and Sciences
Nick Barker
Nick Barker Agency for Science, Technology and Research
Toshiro Sato
Toshiro Sato Keio University
Alexander van Oudenaarden
Alexander van Oudenaarden University Medical Center Utrecht
Peter J. Peters
Peter J. Peters Maastricht University
Bon-Kyoung Koo
Bon-Kyoung Koo Austrian Academy of Sciences
Benjamin D. Simons
Benjamin D. Simons University of Cambridge
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
Dominic Grün
Dominic Grün Max Planck Society

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