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2025
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Immunology
Germany
2026

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Best Scientists

D-Index
175
Citations
121419
World Ranking
717
National Ranking
31

Immunology

D-Index
176
Citations
122432
World Ranking
43
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Immunology in Germany Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Immunology in Germany Leader Award
  • 2023 - Research.com Immunology in Germany Leader Award
  • 2022 - Research.com Immunology in Germany Leader Award
  • 2001 - Fellow of the American Academy of Arts and Sciences
  • 1996 - Robert Koch Prize
  • 1995 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Microbiology and Immunology
  • 1994 - Member of the National Academy of Sciences
  • 1988 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Klaus Rajewsky is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Subfields in which they have notable publications include Molecular Biology, Immunology, Oncology, Hematology, and Epidemiology.

The research topics addressed by Klaus Rajewsky cover diverse areas including Immune Cell Function and Interaction, CRISPR and Genetic Engineering, Lymphoma Diagnosis and Treatment, T-cell and B-cell Immunology, Advanced biosensing and bioanalysis techniques, Cytomegalovirus and herpesvirus research, and Viral-associated cancers and disorders.

Their recent scientific contributions include the following papers:

  • Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells, 2022, Science Advances
  • CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia, 2020, Molecular Therapy
  • Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis, 2020, Proceedings of the National Academy of Sciences
  • Concomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells, 2022, Cancers
  • LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cells, 2023, Frontiers in Immunology

Frequent co-authors who have collaborated with Klaus Rajewsky include Van Trung Chu, Wiebke Winkler, Thomas Sommermann, Ngoc Tung Tran, and Xun Li.

Their work has been published in prominent venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Proceedings of the National Academy of Sciences, Life Science Alliance, and BIO-PROTOCOL.

Klaus Rajewsky has received several notable awards and memberships, reflecting recognition by the scientific community. These include membership in the European Molecular Biology Organization (EMBO), Academia Europaea since 1988, the National Academy of Sciences since 1994, and the German National Academy of Sciences Leopoldina with a focus on Microbiology and Immunology in 1995.

Additional distinctions include the Robert Koch Prize awarded in 1996 and election as a Fellow of the American Academy of Arts and Sciences in 2001.

Best Publications

  • Interleukin-10-deficient mice develop chronic enterocolitis

    Ralf Kühn;Jürgen Löhler;Donna Rennick;Klaus Rajewsky

  • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

    Daisuke Kitamura;Jürgen Roes;Ralf Kühn;Klaus Rajewsky

  • Clonal selection and learning in the antibody system

    Klaus Rajewsky

  • Inducible gene targeting in mice

    Ralf Kühn;Frieder Schwenk;Michel Aguet;Klaus Rajewsky

  • A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

    John F. Kearney;Andreas Radbruch;Bernhard Liesegang;Klaus Rajewsky

  • Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

    Hua Gu;Jamey D. Marth;Paul C. Orban;Horst Mossmann

  • A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.

    Frieder Schwenk;Udo Baron;Klaus Rajewsky

  • Regulation of the Germinal Center Response by MicroRNA-155

    To-Ha Thai;Dinis Pedro Calado;Stefano Casola;K. Mark Ansel

  • Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

    Chryssa Kanellopoulou;Stefan A. Muljo;Andrew L. Kung;Shridar Ganesan

  • Generation and analysis of interleukin-4 deficient mice.

    R. Kühn;K. Rajewsky;W. Müller

  • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.

    Hua Gu;Yong-Rui Zou;Klaus Rajewsky

  • Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

    Changchun Xiao;Lakshmi Srinivasan;Dinis Pedro Calado;Heide Christine Patterson

  • Intraclonal generation of antibody mutants in germinal centres

    Joshy Jacob;Garnett Kelsoe;Klaus Rajewsky;Ursula Weiss

  • In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

    Kong-Peng Lam;Ralf Kühn;Klaus Rajewsky

  • Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

    Van Trung Chu;Timm Weber;Benedikt Wefers;Wolfgang Wurst

  • Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

    Holger Babbe;Axel Roers;Ari Waisman;Hans Lassmann

  • MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb

    Changchun Xiao;Dinis Pedro Calado;Gunther Galler;To-Ha Thai

  • MicroRNA Control in the Immune System: Basic Principles

    Changchun Xiao;Klaus Rajewsky

  • Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

    J. Rodrigo Mora;Makoto Iwata;Bertus Eksteen;Si-Young Song

  • Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

    Ulf Klein;Klaus Rajewsky;Ralf Küppers

Frequent Co-Authors

Ralf Küppers
Ralf Küppers University of Duisburg-Essen
Werner Müller
Werner Müller University of Manchester
Ralf Kühn
Ralf Kühn Max Delbrück Center for Molecular Medicine
Marc Schmidt-Supprian
Marc Schmidt-Supprian Technical University of Munich
Andreas Radbruch
Andreas Radbruch German Rheumatism Research Centre
Michael Reth
Michael Reth University of Freiburg
Ulf Klein
Ulf Klein University of Leeds
Manolis Pasparakis
Manolis Pasparakis University of Cologne
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Anjana Rao
Anjana Rao La Jolla Institute For Allergy & Immunology

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