What is he best known for?
The fields of study he is best known for:
The scientist’s investigation covers issues in Molecular biology, B cell, Immunology, Cell biology and Antibody.
His studies deal with areas such as Mutation, Gene targeting, Gene, Germinal center and Immunoglobulin light chain as well as Molecular biology.
His work carried out in the field of Germinal center brings together such families of science as Reed–Sternberg cell and CD40.
As a part of the same scientific study, Klaus Rajewsky usually deals with the B cell, concentrating on Naive B cell and frequently concerns with B-1 cell and Memory B cell.
His Cell biology research integrates issues from Cellular differentiation, Antigen, Receptor, Regulation of gene expression and B-cell receptor.
His research investigates the connection between Antibody and topics such as Gene rearrangement that intersect with issues in Somatic cell and Sequence analysis.
His most cited work include:
- Interleukin-10-deficient mice develop chronic enterocolitis (3622 citations)
- Inducible gene targeting in mice (1668 citations)
- A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene (1621 citations)
What are the main themes of his work throughout his whole career to date?
Molecular biology, B cell, Antibody, Immunology and Cell biology are his primary areas of study.
His Molecular biology study integrates concerns from other disciplines, such as Gene rearrangement, Gene, Immunoglobulin heavy chain, Somatic hypermutation and Germinal center.
Klaus Rajewsky has researched Germinal center in several fields, including Virology and Somatic cell.
In his study, Lymphoma is inextricably linked to Cancer research, which falls within the broad field of B cell.
The study of Antibody is intertwined with the study of Antigen in a number of ways.
His Cell biology research is multidisciplinary, relying on both Receptor, breakpoint cluster region, Transcription factor and Cell growth.
He most often published in these fields:
- Molecular biology (54.47%)
- B cell (36.25%)
- Antibody (32.57%)
What were the highlights of his more recent work (between 2012-2020)?
- Cell biology (25.74%)
- Cancer research (9.98%)
- Immunology (29.25%)
In recent papers he was focusing on the following fields of study:
Klaus Rajewsky mostly deals with Cell biology, Cancer research, Immunology, B cell and Cellular differentiation.
His Cell biology study also includes
- breakpoint cluster region and related Antigen, Immunoglobulin light chain, Cell and B-cell receptor,
- Cas9 and related Gene knockin and Homologous recombination.
He interconnects Signal transduction and Ectopic expression in the investigation of issues within Immunology.
Klaus Rajewsky works in the field of B cell, namely Germinal center.
His Germinal center study combines topics from a wide range of disciplines, such as Molecular biology, Somatic hypermutation, Kinase and CD40.
The concepts of his Molecular biology study are interwoven with issues in Gene targeting, Gene and Somatic cell.
Between 2012 and 2020, his most popular works were:
- Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. (747 citations)
- FOXO1 couples metabolic activity and growth state in the vascular endothelium. (265 citations)
- PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones (140 citations)
In his most recent research, the most cited papers focused on:
Klaus Rajewsky spends much of his time researching Cellular differentiation, Cell biology, Cancer research, Genetics and Innate immune system.
Klaus Rajewsky interconnects Regulation of gene expression, Germinal center and Antigen in the investigation of issues within Cellular differentiation.
His Germinal center research also works with subjects such as
- Neuroscience that intertwine with fields like Immunology,
- Cell that intertwine with fields like MAPK/ERK pathway.
The study incorporates disciplines such as Mutation, Transcription factor, B cell and PI3K/AKT/mTOR pathway, Signal transduction in addition to Cancer research.
His research integrates issues of Diffuse large B-cell lymphoma and TRAF3 in his study of B cell.
His Genetically modified mouse study combines topics in areas such as Mutagenesis, Molecular biology and Guide RNA.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
