D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge
Immunology
Germany
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 130 Citations 73,974 328 World Ranking 78 National Ranking 2
Best Scientists D-index 176 Citations 117,664 537 World Ranking 498 National Ranking 15

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Scientist Award

2022 - Research.com Immunology in Germany Leader Award

2001 - Fellow of the American Academy of Arts and Sciences

1996 - Robert Koch Prize

1995 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Microbiology and Immunology

1994 - Member of the National Academy of Sciences

1988 - Member of Academia Europaea

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Immune system

The scientist’s investigation covers issues in Molecular biology, B cell, Immunology, Cell biology and Antibody. His studies deal with areas such as Mutation, Gene targeting, Gene, Germinal center and Immunoglobulin light chain as well as Molecular biology. His work carried out in the field of Germinal center brings together such families of science as Reed–Sternberg cell and CD40.

As a part of the same scientific study, Klaus Rajewsky usually deals with the B cell, concentrating on Naive B cell and frequently concerns with B-1 cell and Memory B cell. His Cell biology research integrates issues from Cellular differentiation, Antigen, Receptor, Regulation of gene expression and B-cell receptor. His research investigates the connection between Antibody and topics such as Gene rearrangement that intersect with issues in Somatic cell and Sequence analysis.

His most cited work include:

  • Interleukin-10-deficient mice develop chronic enterocolitis (3622 citations)
  • Inducible gene targeting in mice (1668 citations)
  • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene (1621 citations)

What are the main themes of his work throughout his whole career to date?

Molecular biology, B cell, Antibody, Immunology and Cell biology are his primary areas of study. His Molecular biology study integrates concerns from other disciplines, such as Gene rearrangement, Gene, Immunoglobulin heavy chain, Somatic hypermutation and Germinal center. Klaus Rajewsky has researched Germinal center in several fields, including Virology and Somatic cell.

In his study, Lymphoma is inextricably linked to Cancer research, which falls within the broad field of B cell. The study of Antibody is intertwined with the study of Antigen in a number of ways. His Cell biology research is multidisciplinary, relying on both Receptor, breakpoint cluster region, Transcription factor and Cell growth.

He most often published in these fields:

  • Molecular biology (54.47%)
  • B cell (36.25%)
  • Antibody (32.57%)

What were the highlights of his more recent work (between 2012-2020)?

  • Cell biology (25.74%)
  • Cancer research (9.98%)
  • Immunology (29.25%)

In recent papers he was focusing on the following fields of study:

Klaus Rajewsky mostly deals with Cell biology, Cancer research, Immunology, B cell and Cellular differentiation. His Cell biology study also includes

  • breakpoint cluster region and related Antigen, Immunoglobulin light chain, Cell and B-cell receptor,
  • Cas9 and related Gene knockin and Homologous recombination. He interconnects Signal transduction and Ectopic expression in the investigation of issues within Immunology.

Klaus Rajewsky works in the field of B cell, namely Germinal center. His Germinal center study combines topics from a wide range of disciplines, such as Molecular biology, Somatic hypermutation, Kinase and CD40. The concepts of his Molecular biology study are interwoven with issues in Gene targeting, Gene and Somatic cell.

Between 2012 and 2020, his most popular works were:

  • Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. (747 citations)
  • FOXO1 couples metabolic activity and growth state in the vascular endothelium. (265 citations)
  • PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones (140 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Immune system

Klaus Rajewsky spends much of his time researching Cellular differentiation, Cell biology, Cancer research, Genetics and Innate immune system. Klaus Rajewsky interconnects Regulation of gene expression, Germinal center and Antigen in the investigation of issues within Cellular differentiation. His Germinal center research also works with subjects such as

  • Neuroscience that intertwine with fields like Immunology,
  • Cell that intertwine with fields like MAPK/ERK pathway.

The study incorporates disciplines such as Mutation, Transcription factor, B cell and PI3K/AKT/mTOR pathway, Signal transduction in addition to Cancer research. His research integrates issues of Diffuse large B-cell lymphoma and TRAF3 in his study of B cell. His Genetically modified mouse study combines topics in areas such as Mutagenesis, Molecular biology and Guide RNA.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Interleukin-10-deficient mice develop chronic enterocolitis

Ralf Kühn;Jürgen Löhler;Donna Rennick;Klaus Rajewsky.
Cell (1993)

4584 Citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Daisuke Kitamura;Jürgen Roes;Ralf Kühn;Klaus Rajewsky.
Nature (1991)

2691 Citations

Clonal selection and learning in the antibody system

Klaus Rajewsky.
Nature (1996)

2422 Citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

John F. Kearney;Andreas Radbruch;Bernhard Liesegang;Klaus Rajewsky.
Journal of Immunology (1979)

2191 Citations

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

Hua Gu;Jamey D. Marth;Paul C. Orban;Horst Mossmann.
Science (1994)

2163 Citations

Inducible gene targeting in mice

Ralf Kuhn;Frieder Schwenk;Michel Aguet;Klaus Rajewsky.
Science (1995)

2100 Citations

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.

Frieder Schwenk;Udo Baron;Klaus Rajewsky.
Nucleic Acids Research (1995)

1684 Citations

Regulation of the germinal center response by microRNA-155.

To-Ha Thai;Dinis Pedro Calado;Stefano Casola;K. Mark Ansel.
Science (2007)

1675 Citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

Kong-Peng Lam;Ralf Kühn;Klaus Rajewsky.
Cell (1997)

1528 Citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

Chryssa Kanellopoulou;Stefan A. Muljo;Andrew L. Kung;Shridar Ganesan.
Genes & Development (2005)

1513 Citations

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