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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
27009
World Ranking
10519
National Ranking
800

Overview

Ulf Klein is affiliated with the University of Leeds in the United Kingdom and has contributed to research primarily in immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. Their work spans several subfields including immunology, molecular biology, cancer research, oncology, and genetics.

The research carried out by Klein focuses on a variety of key topics as reflected in their publications. These topics include:

  • Immune Cell Function and Interaction
  • NF-κB Signaling Pathways
  • T-cell and B-cell Immunology
  • Cytokine Signaling Pathways and Interactions
  • Immune Response and Inflammation
  • Immunotherapy and Immune Responses
  • Lymphoma Diagnosis and Treatment

Klein has published extensively across prominent scientific journals. Frequent venues for their work include:

  • Nature Metabolism
  • The Journal of Experimental Medicine
  • Nature Immunology
  • Blood
  • Life Science Alliance

Their recent publications demonstrate a focus on the molecular mechanisms underpinning immune regulation and disease processes. Selected papers include:

  • "c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis," 2020, Nature Metabolism
  • "NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation," 2021, Life Science Alliance
  • "Monoallelic IRF5 deficiency in B cells prevents murine lupus," 2021, JCI Insight
  • "NF-κB Mutations in Germinal Center B-Cell Lymphomas: Relation to NF-κB Function in Normal B Cells," 2022, Biomedicines
  • "Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts," 2020, Cells

Collaboration has been a significant aspect of Klein's research, with frequent coauthors including Guilhem Lalle, Yenkel Grinberg-Bleyer, Raphaëlle Lautraite, Allison Voisin, and Julie Twardowski. These collaborations reflect interdisciplinary efforts within immunology and related biomedical fields.

Best Publications

  • ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context

    Adam A. Margolin;Ilya Nemenman;Katia Basso;Ulf Klein

  • Reverse engineering of regulatory networks in human B cells.

    Katia Basso;Adam A Margolin;Gustavo Stolovitzky;Ulf Klein

  • Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

    Ulf Klein;Yuhai Tu;Gustavo A. Stolovitzky;Michela Mattioli

  • Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

    Ulf Klein;Klaus Rajewsky;Ralf Küppers

  • Germinal centres: role in B-cell physiology and malignancy

    Ulf Klein;Riccardo Dalla-Favera

  • Dynamics of B cells in germinal centres

    Nilushi S. De Silva;Ulf Klein

  • The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia

    Ulf Klein;Marie Lia;Marta Crespo;Rachael Siegel

  • Cellular Origin of Human B-Cell Lymphomas

    Ralf Küppers;Ulf Klein;Martin-Leo Hansmann;Klaus Rajewsky

  • Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

    Ulf Klein;Stefano Casola;Giorgio Cattoretti;Qiong Shen

  • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T H 2 responses

    Ye Zheng;Ashutosh Chaudhry;Ashutosh Chaudhry;Arnold Kas;Paul deRoos;Paul deRoos

  • An essential role for the IL-2 receptor in Treg cell function

    Takatoshi Chinen;Arun K Kannan;Andrew G Levine;Xiying Fan

  • BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci

    Laura Pasqualucci;Anna Migliazza;Nicola Fracchiolla;Christopher William

  • Transcriptional control of adipose lipid handling by IRF4.

    Jun Eguchi;Xun Wang;Songtao Yu;Erin E. Kershaw

  • Transcriptional analysis of the B cell germinal center reaction

    Ulf Klein;Yuhai Tu;Gustavo A. Stolovitzky;Jeffrey L. Keller

  • Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

    Kyoko Ochiai;Mark Maienschein-Cline;Giorgia Simonetti;Jianjun Chen

  • Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.

    Ines Schwering;Andreas Bräuninger;Ulf Klein;Berit Jungnickel

  • Somatic hypermutation in normal and transformed human B cells

    U Klein;T Goossens;M Fischer;H Kanzler

  • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

    Tina Goossens;Ulf Klein;Ralf Küppers

  • Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together

    A. Arockia Jeyaprakash;Ulf R. Klein;Doris Lindner;Judith Ebert;Judith Ebert

  • Evidence for a Large Compartment of IgM-Expressing Memory B Cells in Humans

    Ulf Klein;Ralf Küppers;Klaus Rajewsky

Frequent Co-Authors

Riccardo Dalla-Favera
Riccardo Dalla-Favera Columbia University
Klaus Rajewsky
Klaus Rajewsky Max Delbrück Center for Molecular Medicine
Ralf Küppers
Ralf Küppers University of Duisburg-Essen
Andrea Califano
Andrea Califano Columbia University
Govind Bhagat
Govind Bhagat Columbia University
Sankar Ghosh
Sankar Ghosh Columbia University
Laura Pasqualucci
Laura Pasqualucci Columbia University
Brunangelo Falini
Brunangelo Falini University of Perugia
Mark J. Shlomchik
Mark J. Shlomchik University of Pittsburgh
Manolis Pasparakis
Manolis Pasparakis University of Cologne

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