D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 88 Citations 31,901 306 World Ranking 8298 National Ranking 426
Biology and Biochemistry D-index 88 Citations 31,912 307 World Ranking 1701 National Ranking 114

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cancer

His primary scientific interests are in Germinal center, Molecular biology, B cell, Lymphoma and Somatic hypermutation. His Germinal center research is multidisciplinary, relying on both Mutation, Gene rearrangement, Gene, Virology and Naive B cell. His Molecular biology research integrates issues from Reed–Sternberg cell, Germline mutation, Somatic cell, Immunoglobulin D and Clone.

His B cell study incorporates themes from Epigenomics, DNA methylation, Cancer research and Cellular differentiation. In Lymphoma, he works on issues like Antibody, which are connected to breakpoint cluster region. His Somatic hypermutation study is focused on Genetics in general.

His most cited work include:

  • Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells (1003 citations)
  • Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas (847 citations)
  • Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas (847 citations)

What are the main themes of his work throughout his whole career to date?

Ralf Küppers mainly investigates Cancer research, Lymphoma, Germinal center, Molecular biology and B cell. The Cancer research study combines topics in areas such as Cell culture, Tumor suppressor gene, Regulation of gene expression, Epigenetics and Chronic lymphocytic leukemia. His Lymphoma research incorporates themes from Lymphocyte and Gene expression profiling.

Germinal center is a subfield of Genetics that Ralf Küppers explores. Ralf Küppers has included themes like Reed–Sternberg cell, Gene rearrangement, Gene and Immunoglobulin light chain, Antibody in his Molecular biology study. Ralf Küppers combines subjects such as Epigenomics and DNA methylation with his study of B cell.

He most often published in these fields:

  • Cancer research (38.59%)
  • Lymphoma (39.55%)
  • Germinal center (36.66%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cancer research (38.59%)
  • Lymphoma (39.55%)
  • B cell (34.73%)

In recent papers he was focusing on the following fields of study:

Ralf Küppers mostly deals with Cancer research, Lymphoma, B cell, Germinal center and Immunology. His Cancer research research includes elements of Pathogenesis, Immune system, Regulation of gene expression, Epigenetics and Chronic lymphocytic leukemia. His work carried out in the field of Lymphoma brings together such families of science as JUNB and Lymphocyte.

Ralf Küppers interconnects Mutation, Leukemia and Function in the investigation of issues within B cell. His Germinal center research is multidisciplinary, incorporating elements of Phenotype, Somatic hypermutation, B-cell lymphoma, Anaplastic large-cell lymphoma and Clone. His biological study spans a wide range of topics, including Molecular biology, Follicular lymphoma, BCL6 and Somatic cell.

Between 2015 and 2021, his most popular works were:

  • The landscape of genomic alterations across childhood cancers (449 citations)
  • DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia (155 citations)
  • Human memory B cells. (61 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cancer

Ralf Küppers mainly focuses on Cancer research, Lymphoma, Immunology, Germinal center and CD40. His Cancer research research is multidisciplinary, incorporating perspectives in Mutation, Tumor suppressor gene, Regulation of gene expression, Leukemia and Epigenetics. His Leukemia study combines topics in areas such as Fusion gene, Stem cell and B cell.

His Lymphoma research entails a greater understanding of Pathology. His study in Germinal center is interdisciplinary in nature, drawing from both Phenotype, Clone and Cell biology. His study looks at the intersection of Carcinogenesis and topics like Somatic hypermutation with Follicular lymphoma.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Mechanisms of B-cell lymphoma pathogenesis

Ralf Küppers.
Nature Reviews Cancer (2005)

1232 Citations

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

Laura Pasqualucci;Peter Neumeister;Tina Goossens;Gouri Nanjangud.
Nature (2001)

1232 Citations

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

Ulf Klein;Klaus Rajewsky;Ralf Küppers.
Journal of Experimental Medicine (1998)

1073 Citations

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

H Kanzler;R Küppers;M L Hansmann;K Rajewsky.
Journal of Experimental Medicine (1996)

971 Citations

Cellular Origin of Human B-Cell Lymphomas

Ralf Küppers;Ulf Klein;Martin-Leo Hansmann;Klaus Rajewsky.
The New England Journal of Medicine (1999)

926 Citations

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.

Ralf Kuppers;Klaus Rajewsky;Min Zhao;Gunther Simons.
Proceedings of the National Academy of Sciences of the United States of America (1994)

894 Citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

R. Küppers;Min Zhao;M.-L. Hansmann;K. Rajewsky.
The EMBO Journal (1993)

842 Citations

The landscape of genomic alterations across childhood cancers

Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter.
Nature (2018)

840 Citations

Mechanisms of chromosomal translocations in B cell lymphomas.

Ralf Küppers;Ralf Küppers;Riccardo Dalla-Favera.
Oncogene (2001)

834 Citations

The biology of Hodgkin's lymphoma.

Ralf Küppers.
Nature Reviews Cancer (2009)

817 Citations

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