His primary scientific interests are in Germinal center, Molecular biology, B cell, Lymphoma and Somatic hypermutation. His Germinal center research is multidisciplinary, relying on both Mutation, Gene rearrangement, Gene, Virology and Naive B cell. His Molecular biology research integrates issues from Reed–Sternberg cell, Germline mutation, Somatic cell, Immunoglobulin D and Clone.
His B cell study incorporates themes from Epigenomics, DNA methylation, Cancer research and Cellular differentiation. In Lymphoma, he works on issues like Antibody, which are connected to breakpoint cluster region. His Somatic hypermutation study is focused on Genetics in general.
Ralf Küppers mainly investigates Cancer research, Lymphoma, Germinal center, Molecular biology and B cell. The Cancer research study combines topics in areas such as Cell culture, Tumor suppressor gene, Regulation of gene expression, Epigenetics and Chronic lymphocytic leukemia. His Lymphoma research incorporates themes from Lymphocyte and Gene expression profiling.
Germinal center is a subfield of Genetics that Ralf Küppers explores. Ralf Küppers has included themes like Reed–Sternberg cell, Gene rearrangement, Gene and Immunoglobulin light chain, Antibody in his Molecular biology study. Ralf Küppers combines subjects such as Epigenomics and DNA methylation with his study of B cell.
Ralf Küppers mostly deals with Cancer research, Lymphoma, B cell, Germinal center and Immunology. His Cancer research research includes elements of Pathogenesis, Immune system, Regulation of gene expression, Epigenetics and Chronic lymphocytic leukemia. His work carried out in the field of Lymphoma brings together such families of science as JUNB and Lymphocyte.
Ralf Küppers interconnects Mutation, Leukemia and Function in the investigation of issues within B cell. His Germinal center research is multidisciplinary, incorporating elements of Phenotype, Somatic hypermutation, B-cell lymphoma, Anaplastic large-cell lymphoma and Clone. His biological study spans a wide range of topics, including Molecular biology, Follicular lymphoma, BCL6 and Somatic cell.
Ralf Küppers mainly focuses on Cancer research, Lymphoma, Immunology, Germinal center and CD40. His Cancer research research is multidisciplinary, incorporating perspectives in Mutation, Tumor suppressor gene, Regulation of gene expression, Leukemia and Epigenetics. His Leukemia study combines topics in areas such as Fusion gene, Stem cell and B cell.
His Lymphoma research entails a greater understanding of Pathology. His study in Germinal center is interdisciplinary in nature, drawing from both Phenotype, Clone and Cell biology. His study looks at the intersection of Carcinogenesis and topics like Somatic hypermutation with Follicular lymphoma.
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Mechanisms of B-cell lymphoma pathogenesis
Ralf Küppers.
Nature Reviews Cancer (2005)
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
Laura Pasqualucci;Peter Neumeister;Tina Goossens;Gouri Nanjangud.
Nature (2001)
Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells
Ulf Klein;Klaus Rajewsky;Ralf Küppers.
Journal of Experimental Medicine (1998)
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.
H Kanzler;R Küppers;M L Hansmann;K Rajewsky.
Journal of Experimental Medicine (1996)
Cellular Origin of Human B-Cell Lymphomas
Ralf Küppers;Ulf Klein;Martin-Leo Hansmann;Klaus Rajewsky.
The New England Journal of Medicine (1999)
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.
Ralf Kuppers;Klaus Rajewsky;Min Zhao;Gunther Simons.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.
R. Küppers;Min Zhao;M.-L. Hansmann;K. Rajewsky.
The EMBO Journal (1993)
The landscape of genomic alterations across childhood cancers
Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter.
Nature (2018)
Mechanisms of chromosomal translocations in B cell lymphomas.
Ralf Küppers;Ralf Küppers;Riccardo Dalla-Favera.
Oncogene (2001)
The biology of Hodgkin's lymphoma.
Ralf Küppers.
Nature Reviews Cancer (2009)
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