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Molecular Biology

D-Index
72
Citations
37646
World Ranking
1299
National Ranking
96

Overview

Ralf Kühn is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research spans primarily across the fields of Biochemistry, Genetics, and Molecular Biology, with a total of 82 publications in these areas. Additionally, they have contributed to Medicine through 28 publications. Their subfields of specialization include Molecular Biology, Physiology, Genetics, Immunology, and Oncology.

The scientist's work extensively covers several main topics, including:

  • CRISPR and Genetic Engineering
  • RNA Research and Splicing
  • Pluripotent Stem Cells Research
  • RNA and protein synthesis mechanisms
  • Genomics and Chromatin Dynamics
  • Immune Cell Function and Interaction
  • Mitochondrial Function and Pathology

Ralf Kühn has authored research in notable publication venues, frequently contributing to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Immunology
  • Nature Genetics
  • immuneACCESS

Some of the recent papers by Ralf Kühn include:

  • Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome, 2021, Nature Communications
  • A resource of targeted mutant mouse lines for 5,061 genes, 2021, Nature Genetics
  • In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation, 2022, Nature Genetics
  • Microglia sense neuronal activity via GABA in the early postnatal hippocampus, 2021, Cell Reports
  • Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth, 2022, Nature Communications

The scientist collaborates regularly with researchers including Thomas Blankenstein, Nikolaus Rajewsky, Ngoc Tung Tran, Eric Danner, and Klaus Rajewsky, with multiple joint publications.

Besides research articles, Ralf Kühn has also contributed to academic literature through book publications, including the book Der Erst-Lebendige, published by Verlag Karl Alber in 2021.

Best Publications

  • Interleukin-10-deficient mice develop chronic enterocolitis

    Ralf Kühn;Jürgen Löhler;Donna Rennick;Klaus Rajewsky

  • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

    Daisuke Kitamura;Jürgen Roes;Ralf Kühn;Klaus Rajewsky

  • Inducible gene targeting in mice

    Ralf Kühn;Frieder Schwenk;Michel Aguet;Klaus Rajewsky

  • QCD Matrix Elements + Parton Showers

    Stefano Catani;Frank Krauss;Bryan R. Webber;Ralf Kuhn;Ralf Kuhn

  • Generation and analysis of interleukin-4 deficient mice.

    R. Kühn;K. Rajewsky;W. Müller

  • ENTEROCOLITIS AND COLON CANCER IN INTERLEUKIN-10 : DEFICIENT MICE ARE ASSOCIATED WITH ABERRANT CYTOKINE PRODUCTION AND CD4+ TH1-LIKE RESPONSES

    Daniel J. Berg;Natalle Davidson;Ralf Kühn;Werner Müller

  • In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

    Kong-Peng Lam;Ralf Kühn;Klaus Rajewsky

  • Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

    Van Trung Chu;Timm Weber;Benedikt Wefers;Wolfgang Wurst

  • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

    Ricardo T. Gazzinelli;M. Wysocka;S Hieny;T Scharton-Kersten

  • Requirement of mammalian DNA polymerase-beta in base-excision repair.

    Robert W. Sobol;Julie K. Horton;Ralf Kühn;Hua Gu

  • Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

    Monika Piwecka;Petar Glažar;Luis R. Hernandez-Miranda;Sebastian Memczak

  • Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

    Liliana Minichiello;Martin Korte;David Wolfer;Ralf Kühn

  • Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

    Daniel J. Berg;Ralf Kuhn;Klaus Rajewsky;Werner Muller

  • MHC class I expression in mice lacking the proteasome subunit LMP-7

    HJ Fehling;W Swat;C Laplace;R Kuhn

  • Conditional gene targeting

    K. Rajewsky;H. Gu;R. Kuhn;U. A. K. Betz

  • Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

    Marianne B Müller;Stephan Zimmermann;Inge Sillaber;Thomas P Hagemeyer

  • T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice

    Natalie J. Davidson;Michael W. Leach;Madeline M. Fort;LuAnn Thompson-Snipes

  • Inducible gene deletion in astroglia and radial glia- : A valuable tool for functional and lineage analysis

    Tetsuji Mori;Kohichi Tanaka;Annalisa Buffo;Wolfgang Wurst

  • Development of an intein-mediated split–Cas9 system for gene therapy

    Dong-Jiunn Jeffery Truong;Karin Kühner;Ralf Kühn;Stanislas Werfel

  • Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

    Lucia Carrera;Ricardo T. Gazzinelli;Raffaello Badolato;Sara Hieny

Frequent Co-Authors

Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Werner Müller
Werner Müller University of Manchester
Klaus Rajewsky
Klaus Rajewsky Max Delbrück Center for Molecular Medicine
Frank Krauss
Frank Krauss Durham University
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
Sara Hieny
Sara Hieny National Institute of Allergy and Infectious Diseases
Allan Bradley
Allan Bradley University of Cambridge
Yann Herault
Yann Herault Institute of Genetics and Molecular and Cellular Biology
Allen W. Cheever
Allen W. Cheever National Institutes of Health

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