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Biology and Biochemistry

D-Index
64
Citations
14592
World Ranking
9674
National Ranking
265

Overview

Luis J. V. Galietta is affiliated with the Telethon Institute Of Genetics And Medicine in Italy and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work primarily focuses on pulmonary and respiratory medicine, with significant involvement in molecular biology, physiology, genetics, and epidemiology subfields.

Their research covers multiple topics, including cystic fibrosis research advances, neonatal respiratory health research, tracheal and airway disorders, inhalation and respiratory drug delivery, ion channel regulation and function, asthma and respiratory diseases, and advanced biosensing and bioanalysis techniques.

Galietta's frequent coauthors include Daniela Guidone, Arianna Venturini, Nicoletta Pedemonte, Valeria Capurro, and Emanuela Pesce. Collaborative efforts with these researchers have contributed to a substantial body of work published in a range of scientific venues.

The most common publication venues for Galietta's research are the Journal of Cystic Fibrosis, European Journal of Medicinal Chemistry, bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, and Frontiers in Pharmacology.

Recent papers authored or coauthored by Luis J. V. Galietta include:

  • Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells, 2020, Cells
  • Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment, 2021, International Journal of Molecular Sciences
  • Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel, 2020, Science Advances
  • The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs, 2022, International Journal of Molecular Sciences
  • Light-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance, 2020, The EMBO Journal

Best Publications

  • TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

    Antonella Caputo;Emanuela Caci;Loretta Ferrera;Nicoletta Pedemonte

  • Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

    Tonghui Ma;Jay R. Thiagarajah;Hong Yang;Nitin D. Sonawane

  • Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening

    Nicoletta Pedemonte;Gergely L. Lukacs;Kai Du;Emanuela Caci

  • Chloride channels as drug targets

    Alan S. Verkman;Luis J. V. Galietta

  • Structure and Function of TMEM16 Proteins (Anoctamins)

    Nicoletta Pedemonte;Luis J. V. Galietta

  • Green fluorescent protein-based halide indicators with improved chloride and iodide affinities.

    Luis J.V Galietta;Peter M Haggie;A.S Verkman

  • Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors: Mechanism, Structure–Activity Analysis, and In Vivo Efficacy

    Chatchai Muanprasat;N. D. Sonawane;Danieli Salinas;Alessandro Taddei

  • Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists.

    Luis V. J. Galietta;Sujatha Jayaraman;A. S. Verkman

  • Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating

    Hong Yang;Anang A. Shelat;R. Kiplin Guy;Vadiraj S. Gopinath

  • High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening.

    Tonghui Ma;L. Vetrivel;Hong Yang;Nicoletta Pedemonte

  • Novel CFTR Chloride Channel Activators Identified by Screening of Combinatorial Libraries Based on Flavone and Benzoquinolizinium Lead Compounds

    Luis J.V. Galietta;Mark F. Springsteel;Masahiro Eda;Edmund J. Niedzinski

  • Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

    Loretta Ferrera;Antonella Caputo;Ifeoma Ubby;Erica Bussani

  • Phenylglycine and Sulfonamide Correctors of Defective ΔF508 and G551D Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Gating

    Nicoletta Pedemonte;Nitin D Sonawane;Alessandro Taddei;Jie Hu

  • Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.

    Xiaohui Fang;Yuanlin Song;Jan Hirsch;Luis J. V. Galietta

  • Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

    Paolo Scudieri;Emanuela Caci;Silvia Bruno;Loretta Ferrera

  • IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro.

    Luis J. V. Galietta;Patrick Pagesy;Chiara Folli;Emanuela Caci

  • Thiocyanate Transport in Resting and IL-4-Stimulated Human Bronchial Epithelial Cells: Role of Pendrin and Anion Channels

    Nicoletta Pedemonte;Emanuela Caci;Elvira Sondo;Antonella Caputo

  • Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains

    O. Moran;L. J. V. Galietta;O. Zegarra-Moran

  • Targeting ion channels in cystic fibrosis

    Marcus A. Mall;Luis J.V. Galietta

  • Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells

    Robert L. Dormer;Renaud Dérand;Ceinwen M. McNeilly;Yvette Mettey

Frequent Co-Authors

Alan S. Verkman
Alan S. Verkman University of California, San Francisco
Roberto Ravazzolo
Roberto Ravazzolo University of Genoa
Giovanni Romeo
Giovanni Romeo University of Bologna
Mark J. Kurth
Mark J. Kurth University of California, Davis
Andrea Rasola
Andrea Rasola University of Padua
Marco Seri
Marco Seri University of Bologna
Frédéric Becq
Frédéric Becq University of Poitiers
Tonghui Ma
Tonghui Ma Dalian Medical University
Gergely L. Lukacs
Gergely L. Lukacs McGill University

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