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Biology and Biochemistry

D-Index
108
Citations
40815
World Ranking
1054
National Ranking
638

Medicine

D-Index
108
Citations
40913
World Ranking
6028
National Ranking
3222

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Paul B. McCray is affiliated with the University of Iowa in the United States and has a research focus primarily in the field of Medicine, with a substantial body of work in Infectious Diseases, Pulmonary and Respiratory Medicine, Molecular Biology, Epidemiology, and Genetics.

Their publication record includes contributions to several key scientific topics, notably:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Respiratory viral infections research
  • Virus-based gene therapy research
  • Tracheal and airway disorders

McCray has published in a variety of scientific venues, with repeated contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Cystic Fibrosis
  • Nature
  • EBioMedicine
  • mBio

Among recent papers, notable works include:

  • "A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies," 2020, Cell
  • "COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice," 2020, Nature
  • "Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment," 2020, Cell
  • "Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract," 2020, EBioMedicine
  • "Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19," 2022, Nature

Throughout their career, McCray has collaborated extensively with frequent coauthors including Alejandro A. Pezzulo, Stanley Perlman, David K. Meyerholz, Christine Wohlford-Lenane, and Andrew L. Thurman.

Their work spans significant topics related to respiratory infections, viral pathogenesis, and respiratory medicine, reflecting varied expertise in molecular and clinical research methods.

McCray's professional recognition includes election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2013 and membership in the Association of American Physicians.

Best Publications

  • Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus

    Paul B. McCray;Lecia Pewe;Christine Wohlford-Lenane;Melissa Hickey

  • ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia

    Hong Peng Jia;Dwight C. Look;Lei Shi;Melissa Hickey

  • Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.

    E V Valore;C H Park;A J Quayle;K R Wiles

  • Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.

    Morgan L. Maeder;Stacey Thibodeau-Beganny;Anna Osiak;David A. Wright

  • Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

    Alejandro A. Pezzulo;Xiao Xiao Tang;Mark J. Hoegger;Mahmoud H. Abou Alaiwa

  • Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.

    Christopher S. Rogers;David A. Stoltz;David K. Meyerholz;Lynda S. Ostedgaard

  • Current prospects for RNA interference-based therapies

    Beverly L. Davidson;Paul B. McCray

  • Production of β-defensins by human airway epithelia

    Pradeep K. Singh;Hong Peng Jia;Kerry Wiles;Jay Hesselberth

  • Adherens junction protein nectin-4 is the epithelial receptor for measles virus

    Michael D. Mühlebach;Mathieu Mateo;Patrick L. Sinn;Steffen Prüfer

  • Discovery of five conserved β-defensin gene clusters using a computational search strategy

    Brian C. Schutte;Joseph P. Mitros;Jennifer A. Bartlett;Jesse D. Walters

  • Antimicrobial peptides in animals and their role in host defences

    Kim A. Brogden;Mark R. Ackermann;Paul B. McCray Jr.;Brian F. Tack

  • IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

    Rudragouda Channappanavar;Anthony R. Fehr;Jian Zheng;Christine Wohlford-Lenane

  • Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

    David A. Stoltz;David K. Meyerholz;Alejandro A. Pezzulo;Shyam Ramachandran

  • A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.

    Ahmed O. Hassan;James Brett Case;Emma S. Winkler;Larissa B. Thackray

  • Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

    Kun Li;Christine Wohlford-Lenane;Stanley Perlman;Jincun Zhao

  • Production of β-Defensin Antimicrobial Peptides by the Oral Mucosa and Salivary Glands

    Michael Mathews;Hong Peng Jia;Janet M. Guthmiller;Garrett Losh

  • Rapid generation of a mouse model for Middle East respiratory syndrome

    Jincun Zhao;Kun Li;Christine Wohlford-Lenane;Sudhakar S. Agnihothram

  • Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB

    Salih Sanlioglu;Carl M. Williams;Lobelia Samavati;Noah S. Butler

  • The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus.

    David J. Schibli;Howard N. Hunter;Vladimir Aseyev;Timothy D. Starner

  • Gene Therapy Progress and Prospects: Development of improved lentiviral and retroviral vectors – design, biosafety, and production

    P L Sinn;S L Sauter;P B McCray

Frequent Co-Authors

Michael J. Welsh
Michael J. Welsh University of Iowa
David K. Meyerholz
David K. Meyerholz University of Iowa
Beverly L. Davidson
Beverly L. Davidson Children's Hospital of Philadelphia
Stanley Perlman
Stanley Perlman University of Iowa
Joseph Zabner
Joseph Zabner University of Iowa
David A. Stoltz
David A. Stoltz University of Iowa
Brian F. Tack
Brian F. Tack University of Iowa
Todd E. Scheetz
Todd E. Scheetz University of Iowa
Kim A. Brogden
Kim A. Brogden University of Iowa
Brian C. Schutte
Brian C. Schutte Michigan State University

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