D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 92 Citations 27,304 232 World Ranking 595 National Ranking 340

Research.com Recognitions

Awards & Achievements

2019 - Fellow, National Academy of Inventors

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

John F. Engelhardt mostly deals with Genetic enhancement, Molecular biology, Cell biology, Cystic fibrosis and Gene expression. His Genetic enhancement research is multidisciplinary, incorporating elements of Virus, Virology, Viral vector and Transgene. His Molecular biology research is multidisciplinary, relying on both Gene delivery, Adeno-associated virus, Transcription factor, Tyrosine phosphorylation and In vivo.

His biological study spans a wide range of topics, including Duchenne muscular dystrophy and Endocytosis. His Cystic fibrosis study combines topics from a wide range of disciplines, such as Pancreatic disease, Lung, Immunology and Pathology. The study incorporates disciplines such as Cancer research and Recombinant DNA in addition to Gene expression.

His most cited work include:

  • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver (632 citations)
  • Submucosal glands are the predominant site of CFTR expression in the human bronchus. (577 citations)
  • A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis (520 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Cell biology, Cystic fibrosis, Molecular biology, Genetic enhancement and Pathology. In his study, which falls under the umbrella issue of Cell biology, Virus, Virology, Intracellular, Cell culture and Ubiquitin is strongly linked to Transduction. The Cystic fibrosis study combines topics in areas such as Lung, Immunology and Pancreas.

He has included themes like Enhancer, Transcription factor, Wild type and Adeno-associated virus in his Molecular biology study. His research integrates issues of Gene expression, Viral vector and Transgene in his study of Genetic enhancement. The concepts of his Cystic fibrosis transmembrane conductance regulator study are interwoven with issues in Chloride channel and Endocrinology.

He most often published in these fields:

  • Cell biology (30.00%)
  • Cystic fibrosis (27.63%)
  • Molecular biology (25.26%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cystic fibrosis (27.63%)
  • Cell biology (30.00%)
  • Pathology (18.68%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cystic fibrosis, Cell biology, Pathology, Lung and Cystic fibrosis transmembrane conductance regulator. His work deals with themes such as Endocrinology, Insulin, Pancreas and Genetic enhancement, which intersect with Cystic fibrosis. His Genetic enhancement study improves the overall literature in Gene.

His Cell biology research incorporates elements of Cell type and Transduction. His research on Transduction also deals with topics like

  • Virology, which have a strong connection to Recombinant DNA,

  • Virus, which have a strong connection to Plasmid and Transfection. His Recombinant DNA research also works with subjects such as

  • Transgene that connect with fields like Molecular biology,

  • Human bocavirus together with Adeno-associated virus.

Between 2014 and 2021, his most popular works were:

  • A revised airway epithelial hierarchy includes CFTR-expressing ionocytes (404 citations)
  • Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells (168 citations)
  • Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets. (61 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

His primary areas of study are Cystic fibrosis, Cell biology, Cystic fibrosis transmembrane conductance regulator, Pancreas and Insulin. His Cystic fibrosis research includes elements of CRISPR, Pathogenesis, Pathology, Diabetes mellitus and Genetic enhancement. His studies in Cell biology integrate themes in fields like Cellular differentiation, Immunology and Transduction.

His Immunology research includes themes of Mucociliary clearance and Mucus. His Cystic fibrosis transmembrane conductance regulator research is multidisciplinary, incorporating perspectives in Cell culture, Transgene, Enhancer, Luciferase and Lung. Within one scientific family, John F. Engelhardt focuses on topics pertaining to Plasmid under Respiratory epithelium, and may sometimes address concerns connected to Virology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver

John F. Engelhardt;Xuehai Ye;Benjamin Doranz;James M. Wilson.
Proceedings of the National Academy of Sciences of the United States of America (1994)

776 Citations

Submucosal glands are the predominant site of CFTR expression in the human bronchus.

John F. Engelhardt;James R. Yankaskas;Stephen A. Ernst;Yiping Yang.
Nature Genetics (1992)

757 Citations

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

Mariann Grossman;Mariann Grossman;Steven E. Raper;Steven E. Raper;Karen Kozarsky;Karen Kozarsky;Evan A. Stein.
Nature Genetics (1994)

708 Citations

A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

Michael R Knowles;Kathy W. Hohneker;Zhaoqing Zhou;John C. Olsen.
The New England Journal of Medicine (1995)

668 Citations

Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy

Scott Q. Harper;Michael A. Hauser;Michael A. Hauser;Christiana DelloRusso;Christiana DelloRusso;Dongsheng Duan.
Nature Medicine (2002)

590 Citations

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.

Yiping Yang;Yiping Yang;Frederick A. Nunes;Frederick A. Nunes;Klara Berencsi;Eva Gönczöl.
Nature Genetics (1994)

581 Citations

Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Dongsheng Duan;Prerna Sharma;Jusan Yang;Yongping Yue.
Journal of Virology (1998)

551 Citations

Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

Christopher S. Rogers;Yanhong Hao;Tatiana Rokhlina;Melissa Samuel.
Journal of Clinical Investigation (2008)

469 Citations

Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB

Salih Sanlioglu;Carl M. Williams;Lobelia Samavati;Noah S. Butler.
Journal of Biological Chemistry (2001)

467 Citations

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Daniel T. Montoro;Adam L. Haber;Moshe Biton;Moshe Biton;Vladimir Vinarsky.
Nature (2018)

467 Citations

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