2019 - Fellow, National Academy of Inventors
John F. Engelhardt mostly deals with Genetic enhancement, Molecular biology, Cell biology, Cystic fibrosis and Gene expression. His Genetic enhancement research is multidisciplinary, incorporating elements of Virus, Virology, Viral vector and Transgene. His Molecular biology research is multidisciplinary, relying on both Gene delivery, Adeno-associated virus, Transcription factor, Tyrosine phosphorylation and In vivo.
His biological study spans a wide range of topics, including Duchenne muscular dystrophy and Endocytosis. His Cystic fibrosis study combines topics from a wide range of disciplines, such as Pancreatic disease, Lung, Immunology and Pathology. The study incorporates disciplines such as Cancer research and Recombinant DNA in addition to Gene expression.
His main research concerns Cell biology, Cystic fibrosis, Molecular biology, Genetic enhancement and Pathology. In his study, which falls under the umbrella issue of Cell biology, Virus, Virology, Intracellular, Cell culture and Ubiquitin is strongly linked to Transduction. The Cystic fibrosis study combines topics in areas such as Lung, Immunology and Pancreas.
He has included themes like Enhancer, Transcription factor, Wild type and Adeno-associated virus in his Molecular biology study. His research integrates issues of Gene expression, Viral vector and Transgene in his study of Genetic enhancement. The concepts of his Cystic fibrosis transmembrane conductance regulator study are interwoven with issues in Chloride channel and Endocrinology.
His primary scientific interests are in Cystic fibrosis, Cell biology, Pathology, Lung and Cystic fibrosis transmembrane conductance regulator. His work deals with themes such as Endocrinology, Insulin, Pancreas and Genetic enhancement, which intersect with Cystic fibrosis. His Genetic enhancement study improves the overall literature in Gene.
His Cell biology research incorporates elements of Cell type and Transduction. His research on Transduction also deals with topics like
Virology, which have a strong connection to Recombinant DNA,
Virus, which have a strong connection to Plasmid and Transfection. His Recombinant DNA research also works with subjects such as
Transgene that connect with fields like Molecular biology,
Human bocavirus together with Adeno-associated virus.
His primary areas of study are Cystic fibrosis, Cell biology, Cystic fibrosis transmembrane conductance regulator, Pancreas and Insulin. His Cystic fibrosis research includes elements of CRISPR, Pathogenesis, Pathology, Diabetes mellitus and Genetic enhancement. His studies in Cell biology integrate themes in fields like Cellular differentiation, Immunology and Transduction.
His Immunology research includes themes of Mucociliary clearance and Mucus. His Cystic fibrosis transmembrane conductance regulator research is multidisciplinary, incorporating perspectives in Cell culture, Transgene, Enhancer, Luciferase and Lung. Within one scientific family, John F. Engelhardt focuses on topics pertaining to Plasmid under Respiratory epithelium, and may sometimes address concerns connected to Virology.
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Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
John F. Engelhardt;Xuehai Ye;Benjamin Doranz;James M. Wilson.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Submucosal glands are the predominant site of CFTR expression in the human bronchus.
John F. Engelhardt;James R. Yankaskas;Stephen A. Ernst;Yiping Yang.
Nature Genetics (1992)
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia
Mariann Grossman;Mariann Grossman;Steven E. Raper;Steven E. Raper;Karen Kozarsky;Karen Kozarsky;Evan A. Stein.
Nature Genetics (1994)
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
Michael R Knowles;Kathy W. Hohneker;Zhaoqing Zhou;John C. Olsen.
The New England Journal of Medicine (1995)
Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy
Scott Q. Harper;Michael A. Hauser;Michael A. Hauser;Christiana DelloRusso;Christiana DelloRusso;Dongsheng Duan.
Nature Medicine (2002)
Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.
Yiping Yang;Yiping Yang;Frederick A. Nunes;Frederick A. Nunes;Klara Berencsi;Eva Gönczöl.
Nature Genetics (1994)
Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue
Dongsheng Duan;Prerna Sharma;Jusan Yang;Yongping Yue.
Journal of Virology (1998)
Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer
Christopher S. Rogers;Yanhong Hao;Tatiana Rokhlina;Melissa Samuel.
Journal of Clinical Investigation (2008)
Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB
Salih Sanlioglu;Carl M. Williams;Lobelia Samavati;Noah S. Butler.
Journal of Biological Chemistry (2001)
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
Daniel T. Montoro;Adam L. Haber;Moshe Biton;Moshe Biton;Vladimir Vinarsky.
Nature (2018)
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