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John F. Engelhardt

John F. Engelhardt

D-Index & Metrics

Molecular Biology

D-Index
111
Citations
38362
World Ranking
363
National Ranking
211

Research.com Recognitions

  • 2019 - Fellow, National Academy of Inventors

Overview

John F. Engelhardt is affiliated with the University of Iowa in the United States and has a significant publication record in the fields of medicine and biochemistry, genetics, and molecular biology. Their research predominantly focuses on pulmonary and respiratory medicine, with additional work in molecular biology, genetics, surgery, and infectious diseases.

The primary topics within Engelhardt's research portfolio include neonatal respiratory health research, cystic fibrosis research advances, tracheal and airway disorders, virus-based gene therapy research, respiratory viral infections research, viral gastroenteritis research and epidemiology, and CRISPR and genetic engineering.

Engelhardt has contributed extensively to various scientific journals. Frequent publication venues include the Journal of Cystic Fibrosis, UNC Libraries, American Journal of Respiratory and Critical Care Medicine, Human Gene Therapy, and Molecular Therapy - Methods & Clinical Development.

Collaborations play a significant role in Engelhardt's career, with frequent co-authors including Ziying Yan, Kalpaj R. Parekh, Thomas J. Lynch, Xingshen Sun, and Zehua Feng.

Some of Engelhardt's recent papers highlight their research directions and impact:

  • "Human distal lung maps and lineage hierarchies reveal a bipotent progenitor," published in 2022 in Nature
  • "Human distal airways contain a multipotent secretory cell that can regenerate alveoli," published in 2022 in Nature
  • "Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis," published in 2020 in Cell
  • "Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy," published in 2024 in Nature Biotechnology
  • "Transgenic ferret models define pulmonary ionocyte diversity and function," published in 2023 in Nature

Engelhardt's contributions have been formally recognized with awards such as being named a Fellow of the National Academy of Inventors in 2019.

Best Publications

  • A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

    Daniel T. Montoro;Adam L. Haber;Moshe Biton;Moshe Biton;Vladimir Vinarsky

  • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver

    John F. Engelhardt;Xuehai Ye;Benjamin Doranz;James M. Wilson

  • Submucosal glands are the predominant site of CFTR expression in the human bronchus.

    John F. Engelhardt;James R. Yankaskas;Stephen A. Ernst;Yiping Yang

  • Adenovirus vectors for gene therapy sponsorship

    James M. Wilson;John Engelhardt

  • Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

    Mariann Grossman;Steven E. Raper;Steven E. Raper;Karen Kozarsky;Karen Kozarsky;Evan A. Stein

  • A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

    Michael R Knowles;Kathy W. Hohneker;Zhaoqing Zhou;John C. Olsen

  • Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy

    Scott Q. Harper;Michael A. Hauser;Michael A. Hauser;Christiana DelloRusso;Christiana DelloRusso;Dongsheng Duan

  • Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

    Dongsheng Duan;Prerna Sharma;Jusan Yang;Yongping Yue

  • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.

    Yiping Yang;Yiping Yang;Frederick A. Nunes;Frederick A. Nunes;Klara Berencsi;Eva Gönczöl

  • Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis.

    Thomas H. Sisson;Michael Mendez;Karen Choi;Natalya Subbotina

  • Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB

    Salih Sanlioglu;Carl M. Williams;Lobelia Samavati;Noah S. Butler

  • Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

    Christopher S. Rogers;Yanhong Hao;Tatiana Rokhlina;Melissa Samuel

  • Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

    Dongsheng Duan;Yongping Yue;Ziying Yan;Jusan Yang

  • Airway epithelial cells: current concepts and challenges.

    Ronald G. Crystal;Scott H. Randell;John F. Engelhardt;Judith Voynow

  • CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver.

    R M Zwacka;Y Zhang;J Halldorson;H Schlossberg

  • SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

    Maged M. Harraz;Jennifer J. Marden;Weihong Zhou;Yulong Zhang

  • Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

    Xingshen Sun;Hongshu Sui;John T. Fisher;Ziying Yan

  • Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

    Barbara R. Grubb;Raymond J. Pickles;Hong Ye;James R. Yankaskas

  • Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study.

    Richard H. Simon;John F. Engelhardt;Yiping Yang;Monica Zepeda

  • Endocytosis and Nuclear Trafficking of Adeno-Associated Virus Type 2 Are Controlled by Rac1 and Phosphatidylinositol-3 Kinase Activation

    Salih Sanlioglu;Peter K. Benson;Jusan Yang;E. Morrey Atkinson

Frequent Co-Authors

Ziying Yan
Ziying Yan University of Iowa
James M. Wilson
James M. Wilson University of Pennsylvania
Dongsheng Duan
Dongsheng Duan University of Missouri
Jianming Qiu
Jianming Qiu University of Kansas
Michael J. Welsh
Michael J. Welsh University of Iowa
Yiping Yang
Yiping Yang The Ohio State University
David K. Meyerholz
David K. Meyerholz University of Iowa
Larry W. Oberley
Larry W. Oberley University of Iowa
Randall S. Prather
Randall S. Prather University of Missouri
Yongping Yue
Yongping Yue University of Missouri

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