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Genetics

D-Index
71
Citations
15010
World Ranking
2216
National Ranking
997

Overview

Eric W.F.W. Alton is affiliated with the National Institutes of Health in the United States. Their research spans multiple disciplines within medicine and molecular biology, primarily focusing on pulmonary and respiratory medicine, genetics, and infectious diseases. The scientist has published extensively in the intersecting fields of genetics, molecular biology, and respiratory health.

Alton's scholarly work has addressed a diverse set of topics, including:

  • Cystic fibrosis research advances
  • Neonatal respiratory health research
  • Virus-based gene therapy research
  • Energy harvesting in wireless networks
  • Respiratory viral infections research
  • Viral gastroenteritis research and epidemiology
  • Bacteriophages and microbial interactions

Frequent coauthors contributing to collaborative research include Jane C. Davies, Uta Griesenbach, Deborah R. Gill, Stephen C. Hyde, and Gerry McLachlan. This collaborative network reflects ongoing partnerships in gene therapy and cystic fibrosis research.

Alton's recent publications illustrate a focus on gene therapy and cystic fibrosis, as well as genetic factors underpinning respiratory disorders. Selected works include:

  • "Identification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations" (2021), American Journal of Medical Genetics Part A
  • "The feasibility of home monitoring of young people with cystic fibrosis: Results from CLIMB-CF" (2021), Journal of Cystic Fibrosis
  • "Progress in Respiratory Gene Therapy" (2022), Human Gene Therapy
  • "Lentiviral Gene Therapy for Cystic Fibrosis: A Promising Approach and First-in-Human Trial" (2024), American Journal of Respiratory and Critical Care Medicine
  • "Whole-Gene Sequencing of CFTR Reveals a High Prevalence of the Intronic Variant c.3874-4522A>G in Cystic Fibrosis" (2020), American Journal of Respiratory and Critical Care Medicine

Alton has contributed to the body of research primarily published in venues focused on respiratory and genetic medicine. Key journals where their work appears most frequently include the Journal of Cystic Fibrosis, Thorax, American Journal of Respiratory and Critical Care Medicine, Human Gene Therapy, and American Journal of Medical Genetics Part A.

Their expertise is centered on addressing complex pulmonary conditions, with a sustained concentration on cystic fibrosis, gene therapy innovations, and the genetic underpinnings of respiratory diseases. This is evidenced by the volume and nature of research outputs and topics covered throughout their career.

Best Publications

  • Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.

    Natasha J. Caplen;Eric W.F.W. Alton;Peter G. Mddleton;Julia R. Dorin

  • Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.

    E. W. F. W. Alton;M. Stern;R. Farley;A. Jaffe

  • Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

    E W Alton;P G Middleton;N J Caplen;S N Smith

  • Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

    Eric W F W Alton;David K Armstrong;Deborah Ashby;Katie J Bayfield

  • Cystic fibrosis in the mouse by targeted insertional mutagenesis.

    Julia R. Dorin;Paul Dickinson;Eric W. F. W. Alton;Stephen N. Smith

  • CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

    Stephen C Hyde;Ian A Pringle;Syahril Abdullah;Syahril Abdullah;Anna E Lawton

  • Clinical Review : Cystic fibrosis

    Jane C Davies;Eric W F W Alton;Andrew Bush

  • Efficient gene transfer to airway epithelium using recombinant Sendai virus

    Yoshikazu Yonemitsu;Christopher Kitson;Stefano Ferrari;Raymond Farley

  • Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis

    A R Horsley;P M Gustafsson;K A Macleod;C Saunders

  • Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis.

    Stefano Ferrari;Duncan M Geddes;Eric W.F.W Alton

  • In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE

    N. J. Caplen;E. Kinrade;F. Sorgi;X. Gao

  • Increased Airway Smooth Muscle Mass in Children with Asthma, Cystic Fibrosis, and Non-Cystic Fibrosis Bronchiectasis

    Nicolas Regamey;Matthias Ochs;Tom N. Hilliard;Christian Mühlfeld

  • Airway remodelling in children with cystic fibrosis.

    Tom N Hilliard;Nicolas Regamey;Janis K Shute;Andrew G Nicholson

  • Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium

    P. G. Middleton;D. M. Geddes;E. W. F. W. Alton

  • Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy.

    Uta Griesenbach;Eric W F W Alton

  • A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction

    J. R. Dorin;R. Farley;S. Webb;S. N. Smith

  • No added benefit from nebulized amiloride in patients with cystic fibrosis

    A. Graham;A. Hasani;E. W. F. W. Alton;G. P. Martin

  • The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro

    M Stern;NJ Caplen;JE Browning;U Griesenbach

  • Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.

    Stephen J. Delaney;Eric W.F.W. Alton;Stephen N. Smith;Dominic P. Lunn

  • The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium.

    C Kitson;B Angel;D Judd;S Rothery

Frequent Co-Authors

Uta Griesenbach
Uta Griesenbach National Institutes of Health
Duncan M. Geddes
Duncan M. Geddes Imperial College London
David J. Porteous
David J. Porteous University of Edinburgh
Andrew Bush
Andrew Bush Imperial College London
Mamoru Hasegawa
Mamoru Hasegawa Kyushu University
Ronald K. Scheule
Ronald K. Scheule Sanofi (United States)
Seng H. Cheng
Seng H. Cheng Pfizer (United States)
Stefano Ferrari
Stefano Ferrari Veneto Eye Bank Foundation
Gordon D. Murray
Gordon D. Murray University of Edinburgh
Natasha J. Caplen
Natasha J. Caplen National Institutes of Health

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