Ronald K. Scheule

Overview

Best Publications

• Detailed Analysis of Structures and Formulations of Cationic Lipids for Efficient Gene Transfer to the Lung

  Edward R. Lee;John Marshall;Craig S. Siegel;Canwen Jiang

  617
  Citations

• Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

  Eric W F W Alton;David K Armstrong;Deborah Ashby;Katie J Bayfield

  511
  Citations

• Biophysical characterization of cationic lipid: DNA complexes.

  S.J Eastman;C Siegel;J Tousignant;A.E Smith

  363
  Citations

• BASIS OF PULMONARY TOXICITY ASSOCIATED WITH CATIONIC LIPID-MEDIATED GENE TRANSFER TO THE MAMMALIAN LUNG

  Ronald K. Scheule;Judith A. St. George;Rebecca G. Bagley;John Marshall

  363
  Citations

• Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice.

  Jennifer D. Tousignant;Amy L. Gates;Laurie A. Ingram;Carrie L. Johnson

  331
  Citations

• CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo

  Nelson S. Yew;Hongmei Zhao;Malgorzata Przybylska;I-Huan Wu

  266
  Citations

• Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes

  Nelson S. Yew;Kathryn X. Wang;Malgorzata Przybylska;Rebecca G. Bagley

  250
  Citations

• Development of Catheter-Based Procedures for Transducing the Isolated Rabbit Liver with Plasmid DNA

  Simon J. Eastman;Kevin M. Baskin;Bradley L. Hodges;Qiuming Chu

  198
  Citations

• The role of CpG motifs in immunostimulation and gene therapy.

  Ronald K Scheule

  192
  Citations

• Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy.

  Gregory D Hurlbut;Robin J Ziegler;Jennifer B Nietupski;Joseph W Foley

  173
  Citations

• Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.

  J. Marshall;S. Fang;L.S. Ostedgaard;C.R. O'Riordan

  173
  Citations

• Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides.

  Bradley L. Hodges;Kristin M. Taylor;Macy F. Joseph;Sarah A. Bourgeois

  155
  Citations

• Cationic amphiphile/dna complexes

  Rebecca G. Bagley;Simon J. Eastman;Seng H. Cheng;Edward R. Lee

  139
  Citations

• Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.

  G McLachlan;H Davidson;E Holder;L A Davies

  138
  Citations

• A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high-level gene expression in mouse lung.

  Simon J. Eastman;Michael J. Lukason;Jennifer D. Tousignant;Heather Murray

  132
  Citations

• Bleomycin stimulation of cytokine secretion by the human alveolar macrophage.

  R. K. Scheule;R. C. Perkins;R. Hamilton;A. Holian

  131
  Citations

• Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D

  Kevan L Hartshorn;Richard Webby;Mitchell R White;Tesfaldet Tecle

  127
  Citations

• Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules

  Craig S. Siegel;David J. Harris;Edward R. Lee;Shirley C. Hubbard

  125
  Citations

• Optimization of Formulations and Conditions for the Aerosol Delivery of Functional Cationic Lipid:DNA Complexes

  Simon J. Eastman;Jennifer D. Tousignant;Michael J. Lukason;Heather Murray

  115
  Citations

• Human alveolar macrophage cytokine release in response to in vitro and in vivo asbestos exposure.

  Raymond C. Perkins;Ronald K. Scheule;Raymond Hamilton;Glen Gomes

  115
  Citations