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Molecular Biology

D-Index
90
Citations
29425
World Ranking
738
National Ranking
399

Overview

Seng H. Cheng is affiliated with Pfizer in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions to the fields of medicine. Within these areas, they have concentrated on several subfields including molecular biology, genetics, physiology, cardiology and cardiovascular medicine, and epidemiology.

Their work extensively covers virus-based gene therapy research and lysosomal storage disorders, as well as RNA interference and gene delivery. Additional topics they have addressed include viral infections and immunology research, herpesvirus infections and treatments, cellular transport and secretion, and carbohydrate chemistry and synthesis.

Frequent coauthors in their publications include Martin Schulz, David Lévy, George Bashirians, Ian Winburn, and Suryanarayan Somanathan. These collaborations have spanned multiple studies and areas within their research scope.

Major publication venues where Seng H. Cheng has contributed include Molecular Therapy, Journal of Neurochemistry, Alzheimer's Research & Therapy, Journal of Inherited Metabolic Disease, and Molecular Genetics and Metabolism Reports.

Selected recent papers include:

  • Binding and neutralizing anti-AAV antibodies: Detection and implications for rAAV-mediated gene therapy, 2023, Molecular Therapy
  • Substrate reduction therapy using Genz-667161 reduces levels of pathogenic components in a mouse model of neuronopathic forms of Gaucher disease, 2020, Journal of Neurochemistry
  • Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease, 2022, Alzheimer's Research & Therapy
  • AAV-mediated expression of galactose-1-phosphate uridyltransferase corrects defects of galactose metabolism in classic galactosemia patient fibroblasts, 2021, Journal of Inherited Metabolic Disease
  • Dysregulated DNA methylation in the pathogenesis of Fabry disease, 2022, Molecular Genetics and Metabolism Reports

Best Publications

  • Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

    Seng H. Cheng;Richard J. Gregory;John Marshall;Sucharita Paul

  • Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

    Holly B. Kordasiewicz;Lisa M. Stanek;Edward V. Wancewicz;Curt Mazur

  • Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells.

    Devra P. Rich;Matthew P. Anderson;Richard J. Gregory;Seng H. Cheng

  • Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

    S.H. Cheng;D.P. Rich;J. Marshall;R.J. Gregory

  • Nomenclature for Synthetic Gene Delivery Systems

    P. L. Felgner;Y. Barenholz;J. P. Behr;S. H. Cheng

  • Detailed Analysis of Structures and Formulations of Cationic Lipids for Efficient Gene Transfer to the Lung

    Edward R. Lee;John Marshall;Craig S. Siegel;Canwen Jiang

  • Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src.

    Helen Piwnica-Worms;Kim B Saunders;Thomas M Roberts;Alan E Smith

  • Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy

    Marco A. Passini;Jie Bu;Amy M. Richards;Cathrine Kinnecom

  • Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.

    E. W. F. W. Alton;M. Stern;R. Farley;A. Jaffe

  • Targeting nuclear RNA for in vivo correction of myotonic dystrophy

    Thurman M. Wheeler;Andrew J. Leger;Sanjay K. Pandey;A. Robert MacLeod

  • Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

    Eric W F W Alton;David K Armstrong;Deborah Ashby;Katie J Bayfield

  • Expression and characterization of the cystic fibrosis transmembrane conductance regulator.

    Richard J. Gregory;Seng H. Cheng;Devra P. Rich;John Marshall

  • Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors

    Midori Yamakawa;Louis X. Liu;Taro Date;Adam J. Belanger

  • Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

    Valerie Cullen;S. Pablo Sardi;Juliana Ng;You-Hai Xu

  • A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung

    Carl J. Wheeler;Philip L. Felgner;Yali J. Tsai;John Marshall

  • CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

    Stephen C Hyde;Ian A Pringle;Syahril Abdullah;Syahril Abdullah;Anna E Lawton

  • Biophysical characterization of cationic lipid: DNA complexes.

    S.J Eastman;C Siegel;J Tousignant;A.E Smith

  • BASIS OF PULMONARY TOXICITY ASSOCIATED WITH CATIONIC LIPID-MEDIATED GENE TRANSFER TO THE MAMMALIAN LUNG

    Ronald K. Scheule;Judith A. St. George;Rebecca G. Bagley;John Marshall

  • Improved cationic lipid formulations for in vivo gene therapy

    Philip L. Felgner;Yali J. Tsai;Loretta Sukhu;Carl J. Wheeler

  • CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.

    Marco A. Passini;Jie Bu;Eric M. Roskelley;Amy M. Richards

Frequent Co-Authors

Ronald K. Scheule
Ronald K. Scheule Sanofi (United States)
John Marshall
John Marshall Sanofi (United States)
Richard J. Gregory
Richard J. Gregory Sanofi (United States)
Eric W.F.W. Alton
Eric W.F.W. Alton National Institutes of Health
Uta Griesenbach
Uta Griesenbach National Institutes of Health
Alan E. Smith
Alan E. Smith Sanofi (United States)
David J. Porteous
David J. Porteous University of Edinburgh
Duncan M. Geddes
Duncan M. Geddes Imperial College London
Robert J. Desnick
Robert J. Desnick Icahn School of Medicine at Mount Sinai
Edward H. Schuchman
Edward H. Schuchman Icahn School of Medicine at Mount Sinai

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