World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
56
Citations
17862
World Ranking
2185
National Ranking
1085

Overview

Richard J. Gregory is affiliated with Sanofi in the United States and works primarily within the field of Medicine, with a significant focus on Oncology. Their research covers several specialized subfields including Oncology, Pulmonary and Respiratory Medicine, Epidemiology, Radiology, Nuclear Medicine and Imaging, and Molecular Biology.

The scientist's research topics reveal a strong emphasis on cancer biology and therapeutic approaches. Key areas of work include:

  • HER2/EGFR in Cancer Research
  • Advanced Breast Cancer Therapies
  • Monoclonal and Polyclonal Antibodies Research
  • CAR-T Cell Therapy Research
  • Cytokine Signaling Pathways and Interactions
  • 14-3-3 Protein Interactions
  • Ovarian Cancer Diagnosis and Treatment

Richard J. Gregory has contributed to notable publications, including:

  • Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase In Vivo Efficacy, 2020, Molecular Cancer Therapeutics
  • Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors, 2022, Molecular Cancer Therapeutics
  • Abstract 2890: IMGN151 - A next generation folate receptor alpha targeting antibody drug conjugate active against tumors with low, medium and high receptor expression, 2020, Cancer Research
  • Abstract B21: Synergistic antitumor immunity observed with combination FRα-targeting antibody-drug conjugate plus anti-PD-1 therapy is CD8+ cell dependent, 2020, Cancer Immunology Research
  • Divergent antibody-mediated population immunity to H5, H7 and H9 subtype potential pandemic influenza viruses, 2025, bioRxiv (Cold Spring Harbor Laboratory)

These publications have appeared mainly in venues such as Molecular Cancer Therapeutics, Cancer Research, Cancer Immunology Research, and the bioRxiv preprint server.

Frequent collaborators include:

  • Olga Ab
  • Yulius Y. Setiady
  • Jose F. Ponte
  • Leanne Lanieri
  • Christopher W. Espelin

The range of topics and collaborations suggests a research focus on antibody-based cancer therapies, particularly antibody-drug conjugates and immune-oncology approaches. This includes work on targeting specific receptors in tumors and investigating mechanistic pathways relevant to tumor immunity and treatment response.

Best Publications

  • Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

    Seng H. Cheng;Richard J. Gregory;John Marshall;Sucharita Paul

  • Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

    Matthew P. Anderson;Richard J. Gregory;Simon Thompson;David W. Souza

  • Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

    Joseph Zabner;Larry A. Couture;Richard J. Gregory;Scott M. Graham

  • Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells.

    Devra P. Rich;Matthew P. Anderson;Richard J. Gregory;Seng H. Cheng

  • Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

    S.H. Cheng;D.P. Rich;J. Marshall;R.J. Gregory

  • Generation of cAMP-activated chloride currents by expression of CFTR

    Matthew P. Anderson;Devra P. Rich;Richard J. Gregory;Alan E. Smith

  • Gene therapy for cystic fibrosis

    Richard J. Gregory;Donna Armentano;Larry A. Couture;Alan E. Smith

  • Nucleoside triphosphates are required to open the CFTR chloride channel

    Matthew P. Anderson;Herbert A. Berger;Devra P. Rich;Richard J. Gregory

  • Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties.

    David N. Sheppard;Devra P. Rich;Lynda S. Ostedgaard;Richard J. Gregory;Richard J. Gregory

  • Recombinant adenoviral vector and methods of use

    Richard J. Gregory;Ken N. Wills;Daniel C. Maneval

  • Adenoviral vectors for gene therapy containing deletions in the adenoviral genome

    Richard J. Gregory;Donna Armentano;Larry A. Couture;Alan E. Smith

  • Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor

    Karen A. Vincent;Kou-Gi Shyu;Yuxia Luo;Meredith Magner

  • Expression and characterization of the cystic fibrosis transmembrane conductance regulator.

    Richard J. Gregory;Seng H. Cheng;Devra P. Rich;John Marshall

  • Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors

    Midori Yamakawa;Louis X. Liu;Taro Date;Adam J. Belanger

  • Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats

    Joseph Zabner;Deanna M. Petersen;Aurita P. Puga;Scott M. Graham

  • Effect of deleting the R domain on CFTR-generated chloride channels

    Devra P. Rich;Richard J. Gregory;Matthew P. Anderson;Parthasarathy Manavalan

  • Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer.

    Ken N. Wills;Daniel C. Maneval;Patricia Menzel;Matthew P. Harris

  • Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1.

    Louis X. Liu;Hsienwie Lu;Yuxia Luo;Taro Date

  • Development and Analysis of Recombinant Adenoviruses for Gene Therapy of Cystic Fibrosis

    Devra P. Rich;Larry A. Couture;Lisa M. Cardoza;Vicki M. Guiggio

  • Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.

    R. J. Gregory;D. P. Rich;S. H. Cheng;D. W. Souza

Frequent Co-Authors

Alan E. Smith
Alan E. Smith Sanofi (United States)
Seng H. Cheng
Seng H. Cheng Pfizer (United States)
Michael J. Welsh
Michael J. Welsh University of Iowa
John Marshall
John Marshall Sanofi (United States)
Joseph Zabner
Joseph Zabner University of Iowa
Jeffrey M. Isner
Jeffrey M. Isner Tufts University
Ronald K. Scheule
Ronald K. Scheule Sanofi (United States)
Katherine W. Klinger
Katherine W. Klinger Sanofi (United States)
Roland Buelow
Roland Buelow MedtechAlert
James M. Wilson
James M. Wilson University of Pennsylvania

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