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Biology and Biochemistry

D-Index
91
Citations
31467
World Ranking
2313
National Ranking
1238

Overview

David Piwnica-Worms is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans multiple interconnected fields primarily within Medicine and Biochemistry, Genetics, and Molecular Biology. The scientist focuses particularly on subfields such as Molecular Biology, Radiology, Nuclear Medicine and Imaging, Oncology, Immunology, and Cancer Research.

Their work addresses topics including Cancer, Hypoxia, and Metabolism; Cancer Immunotherapy and Biomarkers; Nanoplatforms for cancer theranostics; Advanced NMR Techniques and Applications; Cancer Research and Treatments; Immune cells in cancer; and Neutrophil, Myeloperoxidase and Oxidative Mechanisms.

Recent publications illustrate the scope and depth of their research. These include:

  • Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context, 2022, eLife
  • Hyperpolarized [1- 13 C]pyruvate-to-[1- 13 C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane, 2020, Proceedings of the National Academy of Sciences
  • Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion, 2023, Science Advances
  • Directed evolution of cyclic peptides for inhibition of autophagy, 2021, Chemical Science
  • Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition, 2020, Nanomedicine Nanotechnology Biology and Medicine

David Piwnica-Worms has collaborated frequently with a number of coauthors, including:

  • Seth T. Gammon
  • Federica Pisaneschi
  • Margie N. Sutton
  • Steven W. Millward
  • Niki M. Zacharias

Their research has been published repeatedly in several scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cells
  • Nuclear Medicine and Biology
  • Cancers

Best Publications

  • Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

    Sonia A. Melo;Linda B. Luecke;Christoph Kahlert;Agustin F. Fernandez

  • Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

    Xuefang Cao;Sheng F. Cai;Todd A. Fehniger;Jiling Song

  • Whole-genome analysis informs breast cancer response to aromatase inhibition

    Matthew J. Ellis;Li Ding;Dong Shen;Jingqin Luo

  • Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

    Jonathan B Mitchem;Donal J Brennan;Brett L Knolhoff;Brian A Belt

  • CXCR4 regulates growth of both primary and metastatic breast cancer.

    Matthew C.P. Smith;Kathryn E. Luker;Joel R. Garbow;Julie L. Prior

  • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model

    John R. Cirrito;Rashid Deane;Anne M. Fagan;Michael L. Spinner

  • Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood- cerebrospinal-fluid drug-permeability barrier

    Vallabhaneni V. Rao;Julie L. Dahlheimer;Mark E. Bardgett;Abraham Z. Snyder

  • Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts.

    Mary L. Chiu;James F. Kronauge;David Piwnica-Worms

  • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

    Bruno Nervi;Pablo Ramirez;Michael P. Rettig;Geoffrey L. Uy

  • Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

    Jeong Sun Ju;Rodrigo A. Fuentealba;Sara E. Miller;Erin Jackson

  • Multidrug resistance transporters and modulation.

    Benjamin Tan;David Piwnica-Worms;Lee Ratner

  • Kinetics of regulated protein–protein interactions revealed with firefly luciferase complementation imaging in cells and living animals

    Kathryn E. Luker;Matthew C. P. Smith;Gary D. Luker;Seth T. Gammon

  • The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

    Kun Zhang;Callie A. Corsa;Suzanne M. Ponik;Julie L. Prior

  • In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia

    Jaebok Choi;Julie Ritchey;Julie L. Prior;Matthew Holt

  • Contribution of p53 to Metastasis

    Emily Powell;David Piwnica-Worms;Helen Piwnica-Worms

  • Bioluminescence imaging of myeloperoxidase activity in vivo.

    Shimon Gross;Seth T Gammon;Britney L Moss;Daniel Rauch

  • Uptake of the Cation Hexakis(2-methoxyisobutylisonitrile)-Technetium-99m by Human Carcinoma Cell Lines in Vitro

    Laurence I. Delmon-Moingeon;David Piwnica-Worms;Annick D. Van den Abbeele;B. Leonard Holman

  • Spying on cancer: molecular imaging in vivo with genetically encoded reporters.

    Shimon Gross;David Piwnica-Worms

  • Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy

    David Piwnica-Worms

  • Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe

    W. Matthew Leevy;Seth T. Gammon;Hua Jiang;James R. Johnson

Frequent Co-Authors

Gary D. Luker
Gary D. Luker University of Michigan–Ann Arbor
John F. DiPersio
John F. DiPersio Washington University in St. Louis
Helen Piwnica-Worms
Helen Piwnica-Worms The University of Texas MD Anderson Cancer Center
Jan A. Nolta
Jan A. Nolta University of California, Davis
Timothy J. Ley
Timothy J. Ley Washington University in St. Louis
Lee Ratner
Lee Ratner Washington University in St. Louis
George W. Gokel
George W. Gokel University of Missouri–St. Louis
Richard S. Hotchkiss
Richard S. Hotchkiss Washington University in St. Louis
Erik D. Herzog
Erik D. Herzog Washington University in St. Louis
David H. Gutmann
David H. Gutmann Washington University in St. Louis

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