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Biology and Biochemistry

D-Index
84
Citations
23443
World Ranking
3349
National Ranking
1687

Research.com Recognitions

  • 2019 - Fellow of the Indian National Academy of Engineering (INAE)
  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2017 - OSA Fellows Samuel Achilefu Washington University in St Louis, United States “for pioneering the development of near infrared molecular imaging and image-guided surgical resection of cancer, and exceptional leadership and service to the biomedical optics community” (Engineering and Science Research)
  • 2017 - Fellow, National Academy of Inventors
  • 2011 - SPIE Fellow

Overview

Samuel Achilefu is affiliated with Washington University in St. Louis in the United States. Their research spans multiple disciplines, including Medicine, Biochemistry, Genetics and Molecular Biology, and Engineering. Within these areas, they have contributed extensively to subfields such as Biomedical Engineering, Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging, and Pulmonary and Respiratory Medicine.

The core themes of their work emphasize nanotechnology and cancer research. Key topics include nanoplatforms for cancer theranostics, monoclonal and polyclonal antibodies research, photoacoustic and ultrasonic imaging, multiple myeloma research and treatments, nanoparticle-based drug delivery, cancer genomics and diagnostics, and CAR-T cell therapy research.

Samuel Achilefu has frequently published in several notable venues, including:

  • Cancer Research
  • Theranostics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Analysis & Sensing

Among their recent papers are:

  • "The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution," 2020, Cell
  • "Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer," 2022, Nature Genetics
  • "Ultrabright fluorescent nanoscale labels for the femtomolar detection of analytes with standard bioassays," 2020, Nature Biomedical Engineering
  • "Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases," 2023, Molecular Cell
  • "Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment," 2021, Journal of Clinical Investigation

Their collaborative work is reflected in frequent coauthorship with researchers such as Rui Tang, John F. DiPersio, Anchal Ghai, Monica Shokeen, and Christopher Egbulefu.

Samuel Achilefu has been recognized with a number of fellowships and honors, including:

  • Fellow of the Indian National Academy of Engineering (INAE), 2019
  • Fellow of the American Association for the Advancement of Science (AAAS), 2018
  • Fellow, National Academy of Inventors, 2017
  • OSA Fellow, 2017, for work in near infrared molecular imaging and image-guided surgical resection of cancer, as well as leadership in biomedical optics
  • SPIE Fellow, 2011

Best Publications

  • Fluorescence Lifetime Measurements and Biological Imaging

    Mikhail Y. Berezin;Samuel Achilefu

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • In Vivo Targeted Deep-Tissue Photodynamic Therapy Based on Near-Infrared Light Triggered Upconversion Nanoconstruct

    Sisi Cui;Deyan Yin;Yuqi Chen;Yingfeng Di

  • Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging.

    Samuel Achilefu;Richard B. Dorshow;Joseph E. Bugaj;Raghavan Rajagopalan

  • Lighting up tumors with receptor-specific optical molecular probes.

    Samuel Achilefu

  • Breaking the Depth Dependency of Phototherapy with Cerenkov Radiation and Low Radiance Responsive Nanophotosensitizers

    Nalinikanth Kotagiri;Gail P. Sudlow;Walter J. Akers;Samuel Achilefu

  • An ‘off-the-shelf’ fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

    Matthew L Cooper;Jaebok Choi;Karl Staser;Julie K Ritchey

  • Fluorescence Manipulation by Gold Nanoparticles: From Complete Quenching to Extensive Enhancement

    Kyung A Kang;Jianting Wang;Jacek B Jasinski;Samuel Achilefu

  • High-Quality CuInS2/ZnS Quantum Dots for In vitro and In vivo Bioimaging

    Dawei Deng;Yuqi Chen;Jie Cao;Junmei Tian

  • Small animal imaging: current technology and perspectives for oncological imaging

    Jason S Lewis;S Achilefu;J.R Garbow;R Laforest

  • Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform.

    Joseph E. Bugaj;Samuel I. Achilefu;Richard B. Dorshow;Raghavan Rajagopalan

  • A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery.

    Changli Du;Dawei Deng;Lingling Shan;Shunan Wan

  • Multimodality Molecular Imaging with Combined Optical and SPECT/PET Modalities

    Joseph Culver;Walter Akers;Samuel Achilefu

  • Multifunctional Gold Nanostar Conjugates for Tumor Imaging and Combined Photothermal and Chemo-therapy

    Haiyan Chen;Xin Zhang;Shuhang Dai;Yuxiang Ma

  • Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging

    Rui Tang;Jianpeng Xue;Baogang Xu;Duanwen Shen

  • Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice.

    Sachin V. Patwardhan;Sharon R. Bloch;Samuel Achilefu;Joseph P. Culver

  • Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors.

    Hyeran Lee;Walter Akers;Kumar Bhushan;Sharon Bloch

  • Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator.

    Jennifer E. Sprague;Yijie Peng;Xiankai Sun;Gary R. Weisman

  • Noninvasive Photoacoustic and Fluorescence Sentinel Lymph Node Identification using Dye-Loaded Perfluorocarbon Nanoparticles

    Walter J. Akers;Chulhong Kim;Mikhail Berezin;Kevin Guo

  • Design, Synthesis, and Evaluation of Near Infrared Fluorescent Multimeric RGD Peptides for Targeting Tumors

    Yunpeng Ye;Sharon Bloch;Baogang Xu;Samuel Achilefu

Frequent Co-Authors

Robert R. Alfano
Robert R. Alfano City College of New York
Ravi Vij
Ravi Vij Washington University in St. Louis
Carolyn J. Anderson
Carolyn J. Anderson University of Pittsburgh
Pratim Biswas
Pratim Biswas University of Miami
John F. DiPersio
John F. DiPersio Washington University in St. Louis
Srikanth Singamaneni
Srikanth Singamaneni Washington University in St. Louis
Gary L. Griffiths
Gary L. Griffiths National Institutes of Health
Lihong V. Wang
Lihong V. Wang California Institute of Technology
Britton Chance
Britton Chance University of Pennsylvania
Chulhong Kim
Chulhong Kim Pohang University of Science and Technology

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