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Biology and Biochemistry

D-Index
123
Citations
98891
World Ranking
542
National Ranking
343

Medicine

D-Index
123
Citations
99087
World Ranking
3260
National Ranking
1799

Research.com Recognitions

  • 2019 - Member of the National Academy of Sciences
  • 2010 - Fellow of the American Academy of Arts and Sciences
  • 2002 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Timothy J. Ley is affiliated with Washington University in St. Louis in the United States. Their research spans fields primarily in Biochemistry, Genetics and Molecular Biology as well as Medicine, with a substantial focus on molecular biology and hematology, along with work in cancer research, immunology, and genetics.

Their research topics cover a range of areas including:

  • Acute Myeloid Leukemia Research
  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation
  • Protein Degradation and Inhibitors
  • Advanced Proteomics Techniques and Applications
  • Immune cells in cancer
  • Multiple Myeloma Research and Treatments

Timothy J. Ley has contributed frequently to several publication venues, notably:

  • Blood
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)

Their recent published papers include:

  • Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers, 2021, New England Journal of Medicine
  • Co-evolution of tumor and immune cells during progression of multiple myeloma, 2021, Nature Communications
  • Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression, 2020, Nature Communications
  • Bam-readcount - rapid generation of basepair-resolution sequence metrics, 2022, The Journal of Open Source Software
  • Proteomic and phosphoproteomic landscapes of acute myeloid leukemia, 2022, Blood

Frequent collaborators in their scientific work include:

  • Christopher A. Miller
  • Sai Mukund Ramakrishnan
  • Nichole Helton
  • David H. Spencer
  • Robert S. Fulton

Among honors received, Timothy J. Ley was made a Member of the National Academy of Sciences in 2019. They were also recognized as a Fellow of the American Academy of Arts and Sciences in 2010 and as a Fellow of the American Association for the Advancement of Science (AAAS) in 2002.

Best Publications

  • The cancer genome atlas pan-cancer analysis project

    John N Weinstein;John N Weinstein;Eric A. Collisson;Gordon B Mills;Kenna R Mills Shaw;Kenna R Mills Shaw

  • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

    Timothy J. Ley;Christopher Miller;Li Ding;Benjamin J. Raphael

  • Mutational landscape and significance across 12 major cancer types

    Cyriac Kandoth;Michael D. McLellan;Fabio Vandin;Kai Ye

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas

    Francisco Sanchez-Vega;Marco Mina;Joshua Armenia;Walid K. Chatila

  • Recurring mutations found by sequencing an acute myeloid leukemia genome.

    Elaine R. Mardis;Li Ding;David J. Dooling;David E. Larson

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Comprehensive Characterization of Cancer Driver Genes and Mutations.

    Matthew H Bailey;Collin Tokheim;Eduard Porta-Pardo;Sohini Sengupta

  • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

    Li Ding;Timothy J. Ley;David E. Larson;Christopher A. Miller

  • DNMT3A Mutations in Acute Myeloid Leukemia

    Timothy J. Ley;Li Ding;Matthew J. Walter;Michael D. McLellan

  • International network of cancer genome projects

    Thomas J. Hudson;Thomas J. Hudson;Warwick Anderson;Axel Aretz;Anna D. Barker

  • Age-related mutations associated with clonal hematopoietic expansion and malignancies

    Mingchao Xie;Charles Lu;Jiayin Wang;Michael D McLellan

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • The origin and evolution of mutations in acute myeloid leukemia.

    John S. Welch;Timothy J. Ley;Daniel C. Link;Christopher A. Miller

  • BreakDancer: An algorithm for high resolution mapping of genomic structural variation

    Ken Chen;John W Wallis;Michael D McLellan;David E Larson

  • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

    Timothy J. Ley;Elaine R. Mardis;Li Ding;Bob Fulton

  • Lymphocyte-Mediated Cytotoxicity

    John H Russell;Timothy J Ley

  • Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

    William J. Grossman;James W. Verbsky;Winfried Barchet;Marco Colonna

  • Genome remodelling in a basal-like breast cancer metastasis and xenograft

    Li Ding;Matthew J C Ellis;Shunqiang Li;David E. Larson

  • Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

    Xuefang Cao;Sheng F. Cai;Todd A. Fehniger;Jiling Song

  • The Cancer Genome Atlas Pan-Cancer analysis project

    Kyle Chang;Chad J Creighton;Caleb Davis;Lawrence Donehower

Frequent Co-Authors

Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Robert S. Fulton
Robert S. Fulton Washington University in St. Louis
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital
John F. DiPersio
John F. DiPersio Washington University in St. Louis
Daniel C. Link
Daniel C. Link Washington University in St. Louis
Peter Westervelt
Peter Westervelt Brown University
Li Ding
Li Ding Washington University in St. Louis
Michael D. McLellan
Michael D. McLellan Washington University in St. Louis
Catrina Fronick
Catrina Fronick Washington University in St. Louis
Vincent Magrini
Vincent Magrini The Ohio State University

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