2026 Richard S. Hotchkiss: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	98	767	702	436	392	351	77727
Medicine	98	8720	8187	4495	4155	353	77731

Overview

Richard S. Hotchkiss is affiliated with Washington University in St. Louis in the United States. Their research primarily focuses on medical and immunological sciences, particularly addressing critical issues related to infectious diseases and immune responses.

The scientist's recent publications span several vital topics in the area of sepsis and COVID-19, reflecting research interests in immune dysregulation and inflammatory processes. Notable papers include:

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections, 2020, published in JCI Insight
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm, 2020, Science Advances
Immunotherapies for COVID-19: lessons learned from sepsis, 2020, The Lancet Respiratory Medicine
Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies, 2024, The Lancet Respiratory Medicine
COVID-19 disease and immune dysregulation, 2022, Best Practice & Research Clinical Haematology

Frequent coauthors collaborating with Richard S. Hotchkiss include Kenneth E. Remy, Monty B. Mazer, Lyle L. Moldawer, Scott C. Brakenridge, and Charles C. Caldwell. This network reflects a collaborative approach toward better understanding sepsis, immune responses, and COVID-19-related pathologies.

The main fields of study for the scientist are Medicine and Immunology and Microbiology. Subfields of significant publication output include infectious diseases, epidemiology, immunology, neurology, and critical care and intensive care medicine.

The research topics covered show a focus on clinical and immunological aspects, notably:

Sepsis Diagnosis and Treatment
COVID-19 Clinical Research Studies
Immune Response and Inflammation
SARS-CoV-2 and COVID-19 Research
Long-Term Effects of COVID-19
Adrenal Hormones and Disorders
Inflammation biomarkers and pathways

Richard S. Hotchkiss regularly publishes in venues such as Shock, JCI Insight, bioRxiv (Cold Spring Harbor Laboratory), Critical Care Explorations, and The Lancet Respiratory Medicine.

Best Publications

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer;Clifford S. Deutschman;Christopher Warren Seymour;Manu Shankar-Hari

29560
Citations
The pathophysiology and treatment of sepsis.

Richard S Hotchkiss;Irene E Karl

6112
Citations
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

Richard S. Hotchkiss;Guillaume Monneret;Didier Payen

3089
Citations
Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

Jonathan S. Boomer;Kathleen To;Kathy C. Chang;Osamu Takasu

2186
Citations
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

Richard S Hotchkiss;Guillaume Monneret;Didier Payen

1799
Citations
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

Hotchkiss Rs;Swanson Pe;Freeman Bd;Tinsley Kw

1709
Citations
Sepsis and septic shock

Richard R.S. Hotchkiss;Lyle Linc Moldawer;Steven Opal;Konrad Reinhart

1547
Citations
MECHANISMS OF DISEASE Cell Death

Richard S. Hotchkiss;Andreas Strasser;Jonathan E. McDunn;Paul E. Swanson

1461
Citations
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans.

Hotchkiss Rs;Tinsley Kw;Swanson Pe;Schmieg Re

1237
Citations
Apoptosis and caspases regulate death and inflammation in sepsis

Richard S. Hotchkiss;Donald W. Nicholson

1086
Citations
Host-directed therapies for bacterial and viral infections

Stefan H. E. Kaufmann;Anca Dorhoi;Richard S. Hotchkiss;Ralf Bartenschlager

824
Citations
A guiding map for inflammation

Mihai G Netea;Frances Balkwill;Michel Chonchol;Fabio Cominelli

819
Citations
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte.

R. S. Hotchkiss;K. C. Chang;P. E. Swanson;K. W. Tinsley

751
Citations
The sepsis seesaw: tilting toward immunosuppression.

Richard S Hotchkiss;Craig M Coopersmith;Jonathan E McDunn;Thomas A Ferguson

711
Citations
Prevention of lymphocyte cell death in sepsis improves survival in mice.

R. S. Hotchkiss;K. W. Tinsley;P. E. Swanson;K. C. Chang

579
Citations
Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

Osamu Takasu;Joseph P. Gaut;Eizo Watanabe;Kathleen To

572
Citations
Depletion of Dendritic Cells, But Not Macrophages, in Patients with Sepsis

Richard S. Hotchkiss;Kevin W. Tinsley;Paul E. Swanson;Mitchell H. Grayson

542
Citations
Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis.

Richard S. Hotchkiss;Irene E. Karl

536
Citations
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

Maya Saleh;John P. Vaillancourt;Rona K. Graham;Matthew Huyck

530
Citations
Persistent lymphopenia after diagnosis of sepsis predicts mortality.

Anne M. Drewry;Navdeep Samra;Lee P. Skrupky;Brian M. Fuller

504
Citations
Overexpression of Bcl-2 in Transgenic Mice Decreases Apoptosis and Improves Survival in Sepsis

Hotchkiss Rs;Swanson Pe;Knudson Cm;Chang Kc

483
Citations

Frequent Co-Authors

Paul E. Swanson University of Washington

W. Michael Dunne bioMérieux (France)

Robert H. Mach University of Pennsylvania

Charles C. Caldwell University of Cincinnati

Lyle L. Moldawer University of Florida

William G. Hawkins Washington University in St. Louis

Joseph J. H. Ackerman Washington University in St. Louis

Thomas A. Ferguson Washington University in St. Louis

Marin H. Kollef Washington University in St. Louis

William C. Chapman Washington University in St. Louis

External Links

Personal website of Richard S. Hotchkiss

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