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D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
19674
World Ranking
6941
National Ranking
3198

Overview

Robert H. Mach is affiliated with the University of Pennsylvania in the United States. Their research spans several fields, primarily focusing on Medicine as well as Biochemistry, Genetics, and Molecular Biology. Within these broader categories, the scientist's work emphasizes subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Radiology, Nuclear Medicine and Imaging, and Physiology.

The scientist's research topics cover various aspects of neuroscience, pharmacology, and cancer therapy. Key areas of study include Parkinson's Disease Mechanisms and Treatments, Receptor Mechanisms and Signaling, PARP inhibition in cancer therapy, Pharmacological Receptor Mechanisms and Effects, Alzheimer's disease research and treatments, Medical Imaging Techniques and Applications, and Neuroscience and Neuropharmacology Research.

Notable recent publications by Robert H. Mach include:

  • ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells, 2021, Nature Cell Biology
  • The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates, 2020, Molecular Neurobiology
  • Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening, 2020, Chemical Science
  • The Biological Function of Sigma-2 Receptor/TMEM97 and Its Utility in PET Imaging Studies in Cancer, 2020, Cancers
  • A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection, 2024, Science

Robert H. Mach frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nuclear Medicine and Biology, Journal of Nuclear Medicine, International Journal of Molecular Sciences, and EJNMMI Radiopharmacy and Chemistry. These journals reflect a blend of basic science, medical imaging, and molecular biology research focuses.

The scientist collaborates regularly with other researchers, including Chia-Ju Hsieh, Hsiaoju Lee, Aladdin Riad, Ji Youn Lee, and E. James Petersson, indicating active engagement in multidisciplinary projects and co-authored investigations.

Best Publications

  • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

    Anne M. Fagan;Mark A. Mintun;Robert H. Mach;Sang-Yoon Lee

  • [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease.

    M. A. Mintun;G. N. LaRossa;Y. I. Sheline;C. S. Dence

  • Social dominance in monkeys: Dopamine D2 receptors and cocaine self-administration

    Drake Morgan;Kathleen A. Grant;H. Donald Gage;Robert H. Mach

  • PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys

    Michael A Nader;Drake Morgan;Drake Morgan;H Donald Gage;Susan H Nader

  • Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

    Anne M. Fagan;Mark A. Mintun;Aarti R. Shah;Patricia Aldea

  • Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

    Andrei G. Vlassenko;S. Neil Vaishnavi;Lars Couture;Dana Sacco

  • Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

    Johannes Gräff;Nadine F. Joseph;Nadine F. Joseph;Meryl E. Horn;Alireza Samiei

  • Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

    Jinbin Xu;Chenbo Zeng;Wenhua Chu;Fenghui Pan

  • Sigma-2 receptors as a biomarker of proliferation in solid tumours.

    K T Wheeler;L M Wang;C A Wallen;S R Childers

  • Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

    Nicholas J. Izzo;Jinbin Xu;Chenbo Zeng;Molly J. Kirk;Molly J. Kirk

  • Consensus nomenclature rules for radiopharmaceutical chemistry - Setting the record straight.

    Heinz H. Coenen;Antony D. Gee;Michael Adam;Gunnar Antoni

  • Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system

    Chenbo Zeng;Fenghui Pan;Lynne A. Jones;Miranda M. Lim

  • Sigma 2 receptors as potential biomarkers of proliferation in breast cancer

    Robert H. Mach;Cynthia R. Smith;Isaf Al-Nabulsi;Brian R. Whirrett

  • Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography.

    Kathleen A. Grant;Carol A. Shively;Michael A. Nader;Richard L. Ehrenkaufer

  • Ibogaine possesses a selective affinity for σ2 receptors

    Robert H. Mach;Cynthia R. Smith;Steven R. Childers

  • The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer

    Robert H. Mach;Chenbo Zeng;William G. Hawkins

  • Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy.

    Chenbo Zeng;Suwanna Vangveravong;Jinbin Xu;Katherine C. Chang

  • Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy.

    Hiroyuki Kashiwagi;Jonathan E McDunn;Peter O Simon;Peter S Goedegebuure

  • N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

    Wenhua Chu;Jun Zhang;Chenbo Zeng;Justin Rothfuss

  • Potential antecedent marker of Alzheimer disease

    M. A. Mintun;G. N. LaRossa;Y. I. Sheline;C. S. Dence

Frequent Co-Authors

David A. Mankoff
David A. Mankoff University of Pennsylvania
William G. Hawkins
William G. Hawkins Washington University in St. Louis
Michael J. Welch
Michael J. Welch Washington University in St. Louis
Mark A. Mintun
Mark A. Mintun University of Pennsylvania
Steven R. Childers
Steven R. Childers Wake Forest University
Hank F. Kung
Hank F. Kung University of Pennsylvania
Joel S. Perlmutter
Joel S. Perlmutter Washington University in St. Louis
Richard S. Hotchkiss
Richard S. Hotchkiss Washington University in St. Louis
Roger A. Greenberg
Roger A. Greenberg University of Pennsylvania
John C. Morris
John C. Morris Washington University in St. Louis

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