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Kostas Pantopoulos

Kostas Pantopoulos

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
14462
World Ranking
13652
National Ranking
474

Overview

Kostas Pantopoulos is affiliated with McGill University in Canada. Their research centers primarily on topics related to iron metabolism and its associated disorders. They have contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with over 100 publications combined across these areas.

The scientist's work covers several main topics, notably:

  • Iron Metabolism and Disorders
  • Hemoglobinopathies and Related Disorders
  • Trace Elements in Health
  • RNA modifications and cancer
  • Liver Disease Diagnosis and Treatment
  • Ferroptosis and cancer prognosis
  • Endoplasmic Reticulum Stress and Disease

Frequent co-authors in their research include Carine Fillebeen, Zhi Luo, Gary Sweeney, Edouard Charlebois, and Xiaolei Wei.

They have published multiple papers in well-known scientific journals. The venues with the highest number of their publications include the International Journal of Molecular Sciences, Blood, Free Radical Biology and Medicine, Cellular and Molecular Life Sciences, and bioRxiv (Cold Spring Harbor Laboratory).

Noteworthy recent papers authored or co-authored by Pantopoulos include:

  • "Oxidative Stress in Liver Pathophysiology and Disease," 2023, Antioxidants
  • "Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway," 2022, Free Radical Biology and Medicine
  • "Basics and principles of cellular and systemic iron homeostasis," 2020, Molecular Aspects of Medicine
  • "Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)," 2020, Pharmaceutics
  • "Regulatory Connections between Iron and Glucose Metabolism," 2020, International Journal of Molecular Sciences

Their research subfields reflect considerable focus on hematology, nutrition and dietetics, genetics, molecular biology, and epidemiology. This multidisciplinary approach supports understanding complex interactions between iron regulation, genetic factors, and disease mechanisms.

Best Publications

  • Iron metabolism and toxicity.

    G. Papanikolaou;K. Pantopoulos;K. Pantopoulos

  • Regulation of cellular iron metabolism

    Jian Wang;Kostas Pantopoulos;Kostas Pantopoulos;Kostas Pantopoulos

  • Mechanisms of mammalian iron homeostasis

    Kostas Pantopoulos;Suheel Kumar Porwal;Alan Michael Tartakoff;L. Devireddy

  • Iron metabolism and the IRE/IRP regulatory system: an update

    Kostas Pantopoulos

  • Iron homeostasis and oxidative stress: An intimate relationship

    Dimitrios Galaris;Alexandra Barbouti;Kostas Pantopoulos

  • Regulation of iron transport and the role of transferrin.

    Konstantinos Gkouvatsos;George Papanikolaou;Kostas Pantopoulos

  • Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway

    G Weiss;B Goossen;W Doppler;D Fuchs

  • Oxidative stress and iron homeostasis: mechanistic and health aspects.

    Dimitrios Galaris;Kostas Pantopoulos

  • Rapid responses to oxidative stress mediated by iron regulatory protein.

    K. Pantopoulos;M.W. Hentze

  • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.

    Duygu Dee Harrison-Findik;Denise Schafer;Elizabeth Klein;Nikolai A. Timchenko

  • The IRP/IRE system in vivo: insights from mouse models

    Nicole Wilkinson;Kostas Pantopoulos

  • Chronic hepatitis C and liver fibrosis

    Giada Sebastiani;Konstantinos Gkouvatsos;Kostas Pantopoulos

  • Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

    Kostas Pantopoulos;Matthias W. Hentze

  • Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements

    Nicola K. Gray;Kostas Pantopoulos;Thomas Dandekar;Brian A. C. Ackrell

  • Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways.

    K Pantopoulos;G Weiss;M W Hentze

  • Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

    Michael Zimmer;Benjamin L. Ebert;Christopher Neil;Keith Brenner

  • Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress

    Kostas Pantopoulos;Sebastian Mueller;Ann Atzberger;Wilhelm Ansorge

  • Activation of iron regulatory protein-1 by oxidative stress in vitro.

    Kostas Pantopoulos;Matthias W. Hentze

  • Iron-Mediated Degradation of IRP2, an Unexpected Pathway Involving a 2-Oxoglutarate-Dependent Oxygenase Activity

    Jian Wang;Guohua Chen;Martina Muckenthaler;Bruno Galy

  • Modulation of cellular iron metabolism by hydrogen peroxide. Effects of H2O2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts.

    Annie Caltagirone;Günter Weiss;Kostas Pantopoulos;Kostas Pantopoulos

Frequent Co-Authors

Matthias W. Hentze
Matthias W. Hentze European Molecular Biology Laboratory
Prem Ponka
Prem Ponka McGill University
Günter Weiss
Günter Weiss Innsbruck Medical University
Hojatollah Vali
Hojatollah Vali McGill University
Antonis E. Koromilas
Antonis E. Koromilas McGill University
Gary Sweeney
Gary Sweeney York University
Wolfgang Stremmel
Wolfgang Stremmel Heidelberg University
Martina U. Muckenthaler
Martina U. Muckenthaler Heidelberg University
Tilman Grune
Tilman Grune University of Potsdam
Hyman M. Schipper
Hyman M. Schipper McGill University

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