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Biology and Biochemistry

D-Index
55
Citations
10063
World Ranking
15143
National Ranking
6334

Overview

Caroline A. Enns is affiliated with Oregon Health & Science University in the United States. Their research primarily spans the field of Medicine with specific focus on Hematology, Genetics, Nutrition and Dietetics, and Physiology. Their body of work concentrates on key topics such as Hemoglobinopathies and Related Disorders, Iron Metabolism and Disorders, Trace Elements in Health, Erythrocyte Function and Pathophysiology, and Erythropoietin and Anemia Treatment.

Enns has contributed to multiple publications, with a notable presence in the journals Blood and Journal of Biological Chemistry. The distribution of their publications shows a balance between these two prominent venues in their field.

  • The ectodomain of matriptase-2 plays an important nonproteolytic role in suppressing hepcidin expression in mice (2020, Blood)
  • Hepatocyte neogenin is required for hemojuvelin-mediated hepcidin expression and iron homeostasis in mice (2021, Blood)
  • Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload (2020, Journal of Biological Chemistry)
  • Matriptase-2 regulates iron homeostasis primarily by setting the basal levels of hepatic hepcidin expression through a nonproteolytic mechanism (2023, Journal of Biological Chemistry)
  • Hepcidin expression is associated with increased γ-secretase-mediated cleavage of neogenin in the liver (2024, Journal of Biological Chemistry)

Their collaborative network includes frequent coauthors such as An-Sheng Zhang, Shall Jue, Richard Zhang, Aaron Wortham, and Devorah C. Goldman. This indicates an active involvement in multidisciplinary teams focused on related medical and biochemical research topics.

Within their field of study, Enns' work has engaged deeply with hematological and genetic mechanisms, particularly those influencing iron regulation and erythropoiesis. This is aligned with their interest in tracing the pathways of hepcidin expression and the physiological handling of iron in mammalian systems.

  • Medicine
  • Hematology
  • Genetics
  • Nutrition and Dietetics
  • Physiology

  • Hemoglobinopathies and Related Disorders
  • Iron Metabolism and Disorders
  • Trace Elements in Health
  • Erythrocyte Function and Pathophysiology
  • Erythropoietin and Anemia Treatment

  • Blood
  • Journal of Biological Chemistry

  • An-Sheng Zhang
  • Shall Jue
  • Richard Zhang
  • Aaron Wortham
  • Devorah C. Goldman

Best Publications

  • Chemistry and biology of eukaryotic iron metabolism.

    Philip Aisen;Caroline Enns;Marianne Wessling-Resnick

  • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.

    Junwei Gao;Juxing Chen;Maxwell Kramer;Hidekazu Tsukamoto;Hidekazu Tsukamoto

  • Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE

    Anthony P. West;Melanie J. Bennett;Vera M. Sellers;Nancy C. Andrews

  • Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.

    Karin Tuschl;Esther Meyer;Leonardo E Valdivia;Ningning Zhao

  • Diferric transferrin regulates transferrin receptor 2 protein stability

    Martha B. Johnson;Caroline A. Enns

  • Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation

    Cindy N. Gross;Alivelu Irrinki;John N. Feder;Caroline A. Enns

  • Iron regulation by hepcidin.

    Ningning Zhao;An Sheng Zhang;Caroline A. Enns

  • The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.

    Cindy N. Roy;David M. Penny;John N. Feder;Caroline A. Enns

  • Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells.

    Alexey J. Merz;Caroline A. Enns;Magdalene So

  • Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes.

    An Sheng Zhang;Shigang Xiong;Shigang Xiong;Shigang Xiong;Hidekazu Tsukamoto;Hidekazu Tsukamoto;Hidekazu Tsukamoto;Caroline A. Enns;Caroline A. Enns;Caroline A. Enns

  • Iron homeostasis: new tales from the crypt

    Cindy N. Roy;Caroline A. Enns

  • The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells

    Lan Lin;Patricia Ayala;Jason Larson;Martha Mulks

  • Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells.

    An Sheng Zhang;Anthony P. West;Anne E. Wyman;Pamela J. Bjorkman

  • Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway

    Gseping Liu;Laurel Thomas;Robin A. Warren;Caroline A. Enns

  • Iron homeostasis: recently identified proteins provide insight into novel control mechanisms.

    An Sheng Zhang;Caroline A. Enns

  • Molecular mechanisms of normal iron homeostasis

    An Sheng Zhang;Caroline A. Enns

  • Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.

    An Sheng Zhang;Sheila A. Anderson;Kathrin R. Meyers;Catalina Hernandez

  • ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin

    Ningning Zhao;Junwei Gao;Caroline A. Enns;Mitchell D. Knutson

  • Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs

    Robin A. Warren;Frank A. Green;Paula E. Stenberg;Caroline A. Enns

  • Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor

    Robin A. Warren;Frank A. Green;Caroline A. Enns

Frequent Co-Authors

Hidekazu Tsukamoto
Hidekazu Tsukamoto University of Southern California
Pamela J. Bjorkman
Pamela J. Bjorkman California Institute of Technology
Magdalene So
Magdalene So University of Arizona
Anthony P. West
Anthony P. West California Institute of Technology
Marianne Wessling-Resnick
Marianne Wessling-Resnick Harvard University
Martina U. Muckenthaler
Martina U. Muckenthaler Heidelberg University
Timothy E. McGraw
Timothy E. McGraw Cornell University
Henry Houlden
Henry Houlden University College London
Holger Prokisch
Holger Prokisch Technical University of Munich
Eamonn R. Maher
Eamonn R. Maher University of Cambridge

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