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Antonis E. Koromilas

Antonis E. Koromilas

D-Index & Metrics

Molecular Biology

D-Index
58
Citations
10941
World Ranking
2097
National Ranking
67

Overview

Antonis E. Koromilas is affiliated with McGill University in Canada and specializes in the field of Biochemistry, Genetics and Molecular Biology. Their research spans primarily Molecular Biology, Cell Biology, and Cancer Research, as well as Biomedical Engineering and Radiology, Nuclear Medicine and Imaging.

The main topics covered in their work include:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Hippo pathway signaling and YAP/TAZ
  • RNA Research and Splicing
  • Endoplasmic Reticulum Stress and Disease
  • RNA regulation and disease
  • Ultrasound and Hyperthermia Applications

Koromilas has collaborated frequently with several co-authors, including Nour Ghaddar, Ivan Topisirović, Jia Yi Zou, Hyungdong Kim, and Maria Hatzoglou.

Their publications appear most often in journals such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Journal of Visualized Experiments, Molecular Cancer Research, and Journal of Clinical Investigation.

Notable recent papers include:

  • "Translational control of breast cancer plasticity" (2020), Nature Communications
  • "The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer" (2021), Nature Communications
  • "SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis" (2022), Journal of Clinical Investigation
  • "A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer" (2024), Proceedings of the National Academy of Sciences
  • "Plasticity of the mammalian integrated stress response" (2025), Nature

Best Publications

  • REGULATION OF PROTEIN SYNTHESIS BY HYPOXIA VIA ACTIVATION OF THE ENDOPLASMIC RETICULUM KINASE PERK AND PHOSPHORYLATION OF THE TRANSLATION INITIATION FACTOR EIF2ALPHA

    Constantinos Koumenis;Christine Naczki;Marianne Koritzinsky;Sally Rastani

  • Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.

    Antonis E. Koromilas;Sophie Roy;Glen N. Barber;Michael G. Katze

  • mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E.

    A E Koromilas;A Lazaris-Karatzas;N Sonenberg

  • Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

    O. Donze;R. Jagus;A. E. Koromilas;J. W. B. Hershey

  • The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.

    Suiyang Li;S. Labrecque;M. C. Gauzzi;A. R. Cuddihy

  • Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

    Ninan Abraham;David F. Stojdl;Peter I. Duncan;Nathalie Méthot

  • Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

    Li Ke Qu;Shirley Huang;Dionissios Baltzis;Ana Maria Rivas-Estilla

  • The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.

    Andrew R Cuddihy;Andrew Hoi-Tao Wong;Nancy Wai Ning Tam;Suiyang Li

  • Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal.

    Victoria Zismanov;Victoria Zismanov;Victor Chichkov;Victor Chichkov;Veronica Colangelo;Veronica Colangelo;Veronica Colangelo;Solène Jamet

  • The Zipper Model of Translational Control: A Small Upstream ORF Is the Switch that Controls Structural Remodeling of an mRNA Leader

    Ibrahim Yaman;James Fernandez;Haiyan Liu;Mark Caprara

  • Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.

    Andrew Hoi‐Tao Wong;Nancy Wai Ning Tam;Yi‐Li Yang;Andrew R. Cuddihy

  • Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.

    Andrew R. Cuddihy;Suiyang Li;Nancy Wai Ning Tam;Andrew Hoi-Tao Wong

  • A Unique ISR Program Determines Cellular Responses to Chronic Stress

    Bo-Jhih Guan;Vincent van Hoef;Raul Jobava;Orna Elroy-Stein

  • Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.

    Bo Jhih Guan;Dawid Krokowski;Mithu Majumder;Christine L. Schmotzer

  • IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.

    S Kirchhoff;A E Koromilas;F Schaper;M Grashoff

  • The eIF2α Kinases PERK and PKR Activate Glycogen Synthase Kinase 3 to Promote the Proteasomal Degradation of p53

    Dionissios Baltzis;Olivier Pluquet;Andreas I. Papadakis;Shirin Kazemi

  • Regulation of Internal Ribosome Entry Site-mediated Translation by Eukaryotic Initiation Factor-2α Phosphorylation and Translation of a Small Upstream Open Reading Frame

    James Fernandez;Ibrahim Yaman;William C. Merrick;Antonis Koromilas

  • Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment.

    Antonis E. Koromilas

  • Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

    Hala Muaddi;Hala Muaddi;Mithu Majumder;Philippos Peidis;Philippos Peidis;Andreas I. Papadakis;Andreas I. Papadakis

  • Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNAiMet Ternary Complex Availability

    Francis Robert;Lee D. Kapp;Shakila N. Khan;Michael G. Acker

Frequent Co-Authors

Maria Hatzoglou
Maria Hatzoglou Case Western Reserve University
Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Nahum Sonenberg
Nahum Sonenberg McGill University
Ivan Topisirovic
Ivan Topisirovic McGill University
Kostas Pantopoulos
Kostas Pantopoulos McGill University
Yoichi Taya
Yoichi Taya National University of Singapore
William C. Merrick
William C. Merrick Case Western Reserve University
Greg Matlashewski
Greg Matlashewski McGill University
Michel L. Tremblay
Michel L. Tremblay McGill University
John Hiscott
John Hiscott Istituto Pasteur

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