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Ivan Topisirovic

Ivan Topisirovic

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
26420
World Ranking
6866
National Ranking
241

Overview

Ivan Topisirovic is affiliated with McGill University in Canada and specializes primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their research encompasses a broad range of topics focusing on molecular mechanisms related to RNA and cancer biology.

The scientist's recent publications include:

  • "Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer" (2020, Nature Communications)
  • "Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR" (2021, Science Advances)
  • "Translational control of breast cancer plasticity" (2020, Nature Communications)
  • "Cancer Plasticity: The Role of mRNA Translation" (2020, Trends in Cancer)
  • "Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth" (2021, Nature Chemical Biology)

Topisirovic's research interests span several main topics, including:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • CRISPR and Genetic Engineering
  • RNA regulation and disease

Their publication record shows frequent collaboration with several co-authors, including:

  • Ola Larsson
  • David Papadopoli
  • Predrag Jovanović
  • Laura Hulea
  • Krzysztof J. Szkop

Topisirovic regularly publishes in well-known scientific journals and platforms. The most frequent venues for their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Chemical Biology
  • Journal of Clinical Investigation
  • Molecular Cell

Their subfields of focus include Molecular Biology, Cancer Research, Oncology, Immunology, and Cell Biology. This multidisciplinary approach reflects the integration of molecular mechanisms with disease contexts, particularly cancer.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Targeting the translation machinery in cancer

    Mamatha Bhat;Nathaniel Robichaud;Laura Hulea;Nahum Sonenberg

  • mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

    Ryan J. O. Dowling;Ivan Topisirovic;Tommy Alain;Michael Bidinosti

  • mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

    Masahiro Morita;Simon Pierre Gravel;Valérie Chénard;Kristina Sikström

  • Dissecting the role of mTOR: lessons from mTOR inhibitors.

    Ryan J.O. Dowling;Ivan Topisirovic;Bruno D. Fonseca;Nahum Sonenberg

  • mTOR coordinates protein synthesis, mitochondrial activity and proliferation.

    Masahiro Morita;Simon Pierre Gravel;Laura Hulea;Ola Larsson

  • Cap and cap-binding proteins in the control of gene expression.

    Ivan Topisirovic;Yuri V. Svitkin;Nahum Sonenberg;Aaron J. Shatkin

  • eIF4E is a central node of an RNA regulon that governs cellular proliferation

    Biljana Culjkovic;Ivan Topisirovic;Lucy Skrabanek;Melisa Ruiz-Gutierrez

  • Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.

    Alex Kentsis;Ivan Topisirovic;Biljana Culjkovic;Ling Shao

  • mTOR as a central regulator of lifespan and aging.

    David Papadopoli;Karine Boulay;Lawrence Kazak;Michael Pollak

  • Signaling Pathways Involved in the Regulation of mRNA Translation.

    Philippe P Roux;Ivan Topisirovic

  • Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities

    Ivan Topisirovic;Melisa Ruiz-Gutierrez;Katherine L. B. Borden

  • mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

    Masahiro Morita;Masahiro Morita;Julien Prudent;Julien Prudent;Kaustuv Basu;Vanessa Goyon

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Translational control of immune responses: from transcripts to translatomes

    Ciriaco A Piccirillo;Eva Bjur;Ivan Topisirovic;Nahum Sonenberg

  • Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.

    Ivan Topisirovic;Monica L. Guzman;Melanie J. McConnell;Jonathan D. Licht

  • eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR

    Biljana Culjkovic;Ivan Topisirovic;Ivan Topisirovic;Lucy Skrabanek;Melisa Ruiz-Gutierrez;Melisa Ruiz-Gutierrez

  • Regulation of mRNA Translation by Signaling Pathways

    Philippe P. Roux;Ivan Topisirovic

  • S6K1 Plays a Critical Role in Early Adipocyte Differentiation

    Larissa S. Carnevalli;Kouhei Masuda;Francesca Frigerio;Olivier Le Bacquer

Frequent Co-Authors

Ola Larsson
Ola Larsson Science for Life Laboratory
Nahum Sonenberg
Nahum Sonenberg McGill University
Katherine L. B. Borden
Katherine L. B. Borden Northwestern University
Julie St-Pierre
Julie St-Pierre McGill University
Michael Pollak
Michael Pollak McGill University
Ze'ev Ronai
Ze'ev Ronai Cedars-Sinai Medical Center
Antonis E. Koromilas
Antonis E. Koromilas McGill University
Evelina Gatti
Evelina Gatti Aix-Marseille University
Ciriaco A. Piccirillo
Ciriaco A. Piccirillo McGill University Health Centre
Maria Hatzoglou
Maria Hatzoglou Case Western Reserve University

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