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Katherine L. B. Borden

Katherine L. B. Borden

D-Index & Metrics

Molecular Biology

D-Index
74
Citations
16711
World Ranking
1243
National Ranking
639

Overview

Katherine L. B. Borden is affiliated with the University of Montreal in Canada. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a strong emphasis on molecular biology as a subfield. The body of work spans multiple aspects of RNA biology and cancer research, highlighting an integration of RNA-related mechanisms with oncological processes.

The main topics of Borden's research include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • PI3K/AKT/mTOR signaling in cancer
  • Cancer-related molecular mechanisms research
  • Cancer-related gene regulation
  • Nuclear Structure and Function

They have published extensively, appearing frequently in notable venues such as:

  • RNA Biology
  • Cancers
  • Journal of Molecular Biology
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Among their recent papers are:

  • The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery, 2020, RNA Biology
  • The eukaryotic translation initiation factor eIF4E elevates steady-state m 7 G capping of coding and noncoding transcripts, 2020, Proceedings of the National Academy of Sciences
  • The Nuclear Pore Complex and mRNA Export in Cancer, 2020, Cancers
  • Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E, 2022, Journal of Molecular Biology
  • The Cap-Binding Complex CBC and the Eukaryotic Translation Factor eIF4E: Co-Conspirators in Cap-Dependent RNA Maturation and Translation, 2021, Cancers

Borden has collaborated frequently with several researchers in the field. Notable coauthors include:

  • Biljana Culjkovic-Kraljacic
  • Jean-Clément Mars
  • María V. Revuelta
  • Jadwiga Gasiorek
  • Leandro Cerchietti

Best Publications

  • Does this have a familiar RING

    Andrew J. Saurin;Katherine L.B. Borden;Michael N. Boddy;Paul S. Freemont

  • Mechanisms and insights into drug resistance in cancer.

    Hiba Zahreddine;Katherine L. B. Borden

  • The RING finger domain: a recent example of a sequence—structure family

    Katherine Lb Borden;Paul S Freemont

  • RING domains: master builders of molecular scaffolds?

    Katherine L.B Borden

  • Identification and preliminary characterization of a protein motif related to the zinc finger.

    Ruth Lovering;Isabel M. Hanson;Katherine L. Borden;Stephen Martin

  • The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.

    K. L. B. Borden;M. N. Boddy;J. Lally;N. J. O'reilly

  • Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies

    Katherine L. B. Borden

  • eIF4E is a central node of an RNA regulon that governs cellular proliferation

    Biljana Culjkovic;Ivan Topisirovic;Lucy Skrabanek;Melisa Ruiz-Gutierrez

  • Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.

    Alex Kentsis;Ivan Topisirovic;Biljana Culjkovic;Ling Shao

  • RING fingers and B-boxes: zinc-binding protein-protein interaction domains.

    Katherine L. B. Borden

  • Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

    Sarit Assouline;Biljana Culjkovic;Eftihia Cocolakis;Caroline Rousseau

  • Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities

    Ivan Topisirovic;Melisa Ruiz-Gutierrez;Katherine L. B. Borden

  • MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

    Lorena Fontan;Lorena Fontan;Chenghua Yang;Venkataraman Kabaleeswaran;Venkataraman Kabaleeswaran;Venkataraman Kabaleeswaran;Laurent Volpon

  • Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

    Allan D. Capili;Allan D. Capili;David C. Schultz;David C. Schultz;Frank J. Rauscher;Katherine L.B. Borden

  • Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.

    Ivan Topisirovic;Monica L. Guzman;Melanie J. McConnell;Jonathan D. Licht

  • PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.

    Natalie Cohen;Madhulika Sharma;Alex Kentsis;Jacqueline M. Perez

  • eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR

    Biljana Culjkovic;Ivan Topisirovic;Ivan Topisirovic;Lucy Skrabanek;Melisa Ruiz-Gutierrez;Melisa Ruiz-Gutierrez

  • The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

    Masha V Poyurovsky;Christina Priest;Alex Kentsis;Katherine L B Borden

  • An Arenavirus RING (Zinc-Binding) Protein Binds the Oncoprotein Promyelocyte Leukemia Protein (PML) and Relocates PML Nuclear Bodies to the Cytoplasm

    Katherine L. B. Borden;Elizabeth J. Campbell Dwyer;Maria S. Salvato

  • In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions

    Ari Melnick;K. Farid Ahmad;K. Farid Ahmad;Sally Arai;Adam Polinger

Frequent Co-Authors

Ivan Topisirovic
Ivan Topisirovic McGill University
Paul S. Freemont
Paul S. Freemont Imperial College London
Ari Melnick
Ari Melnick Cornell University
Wilson H. Miller
Wilson H. Miller McGill University
Maria S. Salvato
Maria S. Salvato University of Maryland, College Park
Stephen R. Martin
Stephen R. Martin The Francis Crick Institute
Hao Wu
Hao Wu Harvard University
Frank J. Rauscher
Frank J. Rauscher The Wistar Institute
Randy D. Gascoyne
Randy D. Gascoyne BC Cancer Agency
Brian Leber
Brian Leber McMaster University

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