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Biology and Biochemistry

D-Index
66
Citations
19069
World Ranking
8538
National Ranking
293

Overview

Brian Leber is affiliated with McMaster University in Canada and has a research profile primarily rooted in the field of Medicine, with significant focus on Hematology, Genetics, and Molecular Biology. Their work spans several subfields including Oncology and Public Health, Environmental and Occupational Health.

Leber's research contributions often concentrate on leukemia and related hematologic conditions. Main topics in their body of work include:

  • Acute Myeloid Leukemia Research
  • Chronic Myeloid Leukemia Treatments
  • Chronic Lymphocytic Leukemia Research
  • Hematopoietic Stem Cell Transplantation
  • Acute Lymphoblastic Leukemia Research
  • Histone Deacetylase Inhibitors Research
  • Neutropenia and Cancer Infections

Several recent papers illustrate the scope of Leber's research interests. Notable publications include:

  • "Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia" (2020), published in New England Journal of Medicine
  • "Long-term follow-up of VIALE-A: Venetoclax and azacitidine in chemotherapy-ineligible untreated acute myeloid leukemia" (2024), published in American Journal of Hematology
  • "Oral decitabine-cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised, crossover, pharmacokinetics, phase 3 study" (2023), published in The Lancet Haematology
  • "Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial" (2021), published in Annals of Hematology
  • "The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells" (2020), published in eLife

Frequent coauthors frequently collaborating with Leber include:

  • Karen Yee
  • Dina Khalaf
  • Mitchell Sabloff
  • Mary-Margaret Keating
  • Rena Buckstein

Leber has published multiple times in prominent venues related to hematology and oncology, notably:

  • Blood
  • Leukemia & lymphoma/Leukemia and lymphoma
  • British Journal of Haematology
  • Clinical Lymphoma Myeloma & Leukemia
  • Current Oncology

Best Publications

  • Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

    Courtney D DiNardo;Brian A Jonas;Vinod Pullarkat;Michael J Thirman

  • Telomerase activity in normal leukocytes and in hematologic malignancies.

    Christopher M. Counter;Jyothi Gupta;Calvin B. Harley;Brian Leber

  • Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

    Eric Daugas;Santos A. Susin;Naoufal Zamzami;Karine F. Ferri

  • Mechanisms of Action of Bcl-2 Family Proteins

    Aisha Shamas-Din;Justin Kale;Brian Leber;David W. Andrews

  • Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

    Jonathan F. Lovell;Lieven P. Billen;Scott Bindner;Aisha Shamas-Din

  • Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

    Eleftherios Sachlos;Ruth M. Risueño;Sarah Laronde;Zoya Shapovalova

  • Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator.

    Catherine Brenner;Hervé Cadiou;Helena La Vieira;Naoufal Zamzami

  • BH3-only proteins: Orchestrators of apoptosis.

    Aisha Shamas-Din;Hetal Brahmbhatt;Brian Leber;David W. Andrews

  • Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes

    Brian Leber;Jialing Lin;David W. Andrews

  • Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

    Matthew G Annis;Erinn L Soucie;Paulina J Dlugosz;Jorge A Cruz-Aguado

  • Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

    W Zhu;A Cowie;G W Wasfy;L Z Penn

  • Bcl-XL inhibits membrane permeabilization by competing with Bax.

    Lieven P Billen;Candis L Kokoski;Jonathan F Lovell;Brian Leber

  • Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

    Sarit Assouline;Biljana Culjkovic;Eftihia Cocolakis;Caroline Rousseau

  • Bcl-2 changes conformation to inhibit Bax oligomerization

    Paulina J Dlugosz;Lieven P Billen;Matthew G Annis;Weijia Zhu

  • Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia

    D J DeAngelo;K E Stevenson;S E Dahlberg;L B Silverman

  • Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy.

    Carolyn J. Owen;Carolyn J. Owen;Cynthia L. Toze;Anna Koochin;Donna L. Forrest

  • Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis

    Jeremy A. Yethon;Raquel F. Epand;Brian Leber;Richard M. Epand

  • Campath-1H Treatment of T-Cell Prolymphocytic Leukemia in Patients for Whom at Least One Prior Chemotherapy Regimen Has Failed

    M. J. Keating;B. Cazin;S. Coutré;R. Birhiray

  • Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis.

    Weijia Zhu;Brian Leber;David W. Andrews

  • Still embedded together binding to membranes regulates Bcl-2 protein interactions.

    B Leber;J Lin;D W Andrews

Frequent Co-Authors

David W. Andrews
David W. Andrews Sunnybrook Health Science Centre
Suzanne Kamel-Reid
Suzanne Kamel-Reid University Health Network
Mickie Bhatia
Mickie Bhatia McMaster University
Mark D. Minden
Mark D. Minden Princess Margaret Cancer Centre
Vikas Gupta
Vikas Gupta Princess Margaret Cancer Centre
Timothy P. Hughes
Timothy P. Hughes South Australian Health and Medical Research Institute
Francisco Cervantes
Francisco Cervantes University of Barcelona
Jorge E. Cortes
Jorge E. Cortes Augusta University
Kenneth Rockwood
Kenneth Rockwood Dalhousie University
Linda Z. Penn
Linda Z. Penn University of Toronto

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