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61
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11546
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Overview

Vanessa Yardley is affiliated with the London School of Hygiene & Tropical Medicine in the United Kingdom. Their research primarily spans the field of Medicine, with notable contributions across Public Health, Environmental and Occupational Health, Epidemiology, Organic Chemistry, Parasitology, and Molecular Biology.

Their research topics emphasize studies on Leishmaniasis and related parasitic diseases. Key areas include:

  • Research on Leishmaniasis Studies
  • Trypanosoma species research and implications
  • Synthesis and Biological Evaluation
  • Parasites and Host Interactions
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Crystallography and molecular interactions
  • Crystallization and Solubility Studies

Vanessa Yardley has published several research papers, some of which include:

  • Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis, 2020, Molecules
  • DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis, 2021, Journal of Medicinal Chemistry
  • Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal, 2020, European Journal of Medicinal Chemistry
  • DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc 1, 2023, Science Translational Medicine
  • Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs, 2020, Microorganisms

Frequent coauthors in Yardley's work include:

  • Simon L. Croft
  • Katrien Van Bocxlaer
  • Stéphanie Braillard
  • Louis Maes
  • Eric Chatelain

Their publications are often found in journals such as:

  • NIHR Open Research
  • Molecular Pharmaceutics
  • Molecules
  • Journal of Medicinal Chemistry
  • Science Translational Medicine

Best Publications

  • Current scenario of drug development for leishmaniasis.

    Simon L Croft;Karin Seifert;Vanessa Yardley

  • Chemotherapy of Leishmaniasis

    Simon L Croft;Vanessa Yardley

  • Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies

    Deniz Tasdemir;Marcel Kaiser;Reto Brun;Vanessa Yardley

  • Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

    Michael B. Martin;Joshua S. Grimley;Jared C. Lewis;Huel T. Heath

  • 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

    L Salmon-Chemin;E Buisine;Yardley;S Kohler

  • Formulation of amphotericin B as nanosuspension for oral administration.

    O Kayser;C Olbrich;V Yardley;A F Kiderlen

  • The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei

    Simon L. Croft;Diane Snowdon;Vanessa Yardley

  • Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.

    Sandra Gemma;Gagan Kukreja;Caterina Fattorusso;Marco Persico

  • Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.

    Alessandro Baliani;Gorka Jimenez Bueno;Mhairi L. Stewart;Vanessa Yardley

  • A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis

    Vanessa Yardley;Simon L Croft

  • Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

    Cecil Chan;Hong Yin;Jacqui Garforth;James H. McKie

  • Gene Expression Analysis of the Mechanism of Natural Sb(V) Resistance in Leishmania donovani Isolates from Nepal

    Saskia Decuypere;Saskia Decuypere;Suman Rijal;Vanessa Yardley;Simonne De Doncker

  • Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis.

    V Yardley;S L Croft

  • In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii

    Vanessa Yardley;Anis A. Khan;Michael B. Martin;Teri R. Slifer

  • Cytotoxicity of (2,2':6',2''-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei.

    Gordon Lowe;Anne Sophie Droz;Tirayut Vilaivan;George W. Weaver

  • THE SENSITIVITY OF CLINICAL ISOLATES OF LEISHMANIA FROM PERU AND NEPAL TO MILTEFOSINE

    Vanessa Yardley;Simon L. Croft;Simonne De Doncker;Jean-Claude Dujardin

  • Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1'-substituted 9-anilinoacridines.

    Swarna A. Gamage;David P. Figgitt;Stanley J. Wojcik;Raymond K. Ralph

  • In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle.

    K. Asres;F. Bucar;E. Knauder;V. Yardley

  • Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

    Kelly Chibale;Hayley Haupt;Howard Kendrick;Vanessa Yardley

  • Activities of Hexadecylphosphocholine (Miltefosine), AmBisome, and Sodium Stibogluconate (Pentostam) against Leishmania donovani in Immunodeficient scid Mice

    Patricia Escobar;Vanessa Yardley;Simon L. Croft

Frequent Co-Authors

Simon L. Croft
Simon L. Croft London School of Hygiene & Tropical Medicine
Susan J. Little
Susan J. Little University of California, San Diego
Donatella Taramelli
Donatella Taramelli University of Milan
Ian H. Gilbert
Ian H. Gilbert University of Dundee
Kelly Chibale
Kelly Chibale University of Cape Town
Louis Maes
Louis Maes University of Antwerp
Sandra Gemma
Sandra Gemma University of Siena
Giuseppe Campiani
Giuseppe Campiani University of Siena
Scott G. Franzblau
Scott G. Franzblau University of Illinois at Chicago
Jean-Claude Dujardin
Jean-Claude Dujardin Institute of Tropical Medicine Antwerp

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