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Biology and Biochemistry

D-Index
73
Citations
15147
World Ranking
6070
National Ranking
1

Research.com Recognitions

  • 1996 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Julio A. Urbina is affiliated with the Instituto Venezolano de Investigaciones Científicas in Venezuela. Their research focus spans several areas within Medicine, particularly emphasizing Epidemiology, Public Health, Environmental and Occupational Health, Parasitology, and Cardiology and Cardiovascular Medicine. The scientist's work includes studies on organic chemistry aspects related to their broader investigations.

The primary topics addressed in their publications include Trypanosoma species research and implications, Research on Leishmaniasis Studies, Parasites and Host Interactions, Synthesis and Biological Evaluation, Cardiomyopathy and Myosin Studies, Viral Infections and Immunology Research, and Helminth infection and control.

Recent papers by Julio A. Urbina cover diverse aspects of parasitic diseases and therapeutic developments. These include:

  • New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia (2021, BMJ Open)
  • Emerging agents for the treatment of Chagas disease: what is in the preclinical and clinical development pipeline? (2020, Expert Opinion on Investigational Drugs)
  • Effect of Posaconazole in an in vitro model of cardiac fibrosis induced by Trypanosoma cruzi (2020, Molecular and Biochemical Parasitology)
  • Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease (2021, Experimental Parasitology)
  • SIBLING AGGRESSION IN A NEOTROPICAL RAPTOR, BLACK-CHESTED BUZZARD-EAGLE (GERANOAETUS MELANOLEUCUS): A FIRST REPORT FOR CHILE (2022, Ornitología Neotropical)

Frequent collaborators in their research are Cristina Alonso-Vega, María-Jesús Pinazo, Joaquím Gascón, Sergi Sanz, and Jimy Pinto.

Julio A. Urbina's scientific articles are published in journals including BMJ Open, Expert Opinion on Investigational Drugs, Molecular and Biochemical Parasitology, Experimental Parasitology, and Ornitología Neotropical.

In recognition of their scholarly work, Julio A. Urbina received the fellowship from the John Simon Guggenheim Memorial Foundation in 1996.

Best Publications

  • Specific chemotherapy of Chagas disease: controversies and advances.

    Julio A. Urbina;Roberto Docampo

  • Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches.

    Julio A. Urbina

  • Chemotherapy of trypanosomiases and leishmaniasis

    Simon L. Croft;Michael P. Barrett;Julio A. Urbina

  • Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

    Michael B. Martin;Joshua S. Grimley;Jared C. Lewis;Huel T. Heath

  • Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31p-NMR spectroscopy

    Julio A. Urbina;Sara Pekerar;Hong biao Le;Jessica Patterson

  • Chemotherapy of Chagas disease.

    Julio A. Urbina

  • The challenges of Chagas Disease-- grim outlook or glimmer of hope.

    Rick L Tarleton;Richard Reithinger;Julio A Urbina;Uriel Kitron

  • Ergosterol biosynthesis and drug development for Chagas disease.

    Julio A Urbina

  • Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts.

    Judith Molina;Olindo Martins-Filho;Zigman Brener;Alvaro J. Romanha

  • Cure of Short- and Long-Term Experimental Chagas' Disease Using D0870

    Julio A. Urbina;Gilberto Payares;Judith Molina;Cristina Sanoja

  • Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites.

    Urbina Ja

  • Toward a Novel Metal-Based Chemotherapy against Tropical Diseases. 2. Synthesis and Antimalarial Activity in Vitro and in Vivo of New Ruthenium− and Rhodium−Chloroquine Complexes

    Roberto A. Sánchez-Delgado;Maribel Navarro;Hilda Pérez;Julio A. Urbina

  • Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.

    Gustavo Benaim;John M. Sanders;Yael Garcia-Marchán;Claudia Colina

  • Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region

    Maria E Grillet;Juan V Hernández-Villena;Martin S Llewellyn;Alberto E Paniz-Mondolfi

  • In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease.

    Julio A Urbina;Gilberto Payares;Cristina Sanoja;Renee Lira

  • Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.

    Julio A. Urbina;Gilberto Payares;Lellys M. Contreras;Andreína Liendo

  • Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives

    Julio A. Urbina

  • Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs.

    Julio A. Urbina;Benjamin Moreno;Stephanie Vierkotter;Eric Oldfield

  • Successful Treatment with Posaconazole of a Patient with Chronic Chagas Disease and Systemic Lupus Erythematosus

    María-Jesús Pinazo;Gerard Espinosa;Montserrat Gállego;Paulo Luis López-Chejade

  • Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.

    K Lazardi;J A Urbina;W de Souza

Frequent Co-Authors

Wanderley de Souza
Wanderley de Souza Federal University of Rio de Janeiro
Ian H. Gilbert
Ian H. Gilbert University of Dundee
Simon L. Croft
Simon L. Croft London School of Hygiene & Tropical Medicine
Eric Oldfield
Eric Oldfield University of Illinois at Urbana-Champaign
Roberto Docampo
Roberto Docampo University of Georgia
Vanessa Yardley
Vanessa Yardley London School of Hygiene & Tropical Medicine
Alvaro J. Romanha
Alvaro J. Romanha Universidade Federal de Santa Catarina
Roberto A. Sánchez-Delgado
Roberto A. Sánchez-Delgado City University of New York
Ricardo T. Gazzinelli
Ricardo T. Gazzinelli Universidade Federal de Minas Gerais
Joaquim Gascon
Joaquim Gascon University of Barcelona

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