World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
29252
World Ranking
3286
National Ranking
1664

Overview

James Varani is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on medicine, with specific attention to physiology, genetics, nutrition and dietetics, pathology and forensic medicine, and oncology.

The main topics addressed in their work include:

  • Trace Elements in Health
  • Vitamin D Research Studies
  • Inflammatory Bowel Disease
  • Gut Microbiota and Health
  • Nutrition and Health in Aging
  • Diet and Metabolism Studies
  • Iron Metabolism and Disorders

Selected recent publications by James Varani include:

  • Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis, 2023, Advanced Science
  • A MULTI-MINERAL INTERVENTION TO IMPROVE DISEASE-RELATED AND MECHANISTIC BIOMARKERS IN ULCERATIVE COLITIS PATIENTS, 2025, bioRxiv (Cold Spring Harbor Laboratory)
  • A MULTI-MINERAL INTERVENTION TO MODULATE COLONIC MUCOSAL PROTEIN PROFILE: Results from a 90-day trial in healthy human subjects, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Liver Proteomic Profile in Mice on a High-Fat Diet: Modulation with Anti-Tumor Intervention, 2022, The FASEB Journal
  • S1193 Improvement in Disease-Related Biomarkers With an Adjuvant Treatment for 180 Days: Results From an Interventional Trial for Patients With Ulcerative Colitis, 2024, The American Journal of Gastroenterology

Frequent co-authors collaborating with Varani include:

  • Muhammad N. Aslam
  • Shannon D. McClintock
  • D. Kim Turgeon
  • Isabelle Harber
  • Ron Allen

Their work has been published repeatedly in several notable venues, including:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Advanced Science
  • The FASEB Journal
  • The American Journal of Gastroenterology

Best Publications

  • Mechanisms of photoaging and chronological skin aging

    Gary J. Fisher;Sewon Kang;James Varani;Zsuzsanna Bata-Csorgo

  • Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light

    Gary J. Fisher;Zeng Quan Wang;Subhash C. Datta;James Varani

  • Molecular basis of sun-induced premature skin ageing and retinoid antagonism

    Gary J. Fisher;Subhash C. Datta;Harvinder S. Talwar;Zeng Quan Wang

  • Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation.

    James Varani;Michael K. Dame;Laure Rittie;Suzanne E.G. Fligiel

  • Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin.

    James Varani;Roscoe L. Warner;Mehrnaz Gharaee-Kermani;Sem H. Phan

  • In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin

    Frank Wang;Luis A. Garza;Luis A. Garza;Sewon Kang;James Varani

  • Looking older: Fibroblast collapse and therapeutic implications

    Gary J. Fisher;James Varani;John J. Voorhees

  • Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats.

    M S Mulligan;J Varani;M K Dame;C L Lane

  • Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.

    Gary J. Fisher;Taihao Quan;Trupta Purohit;Yuan Shao

  • Effects of 5-fluorouracil and Mitomycin C on Cultured Rabbit Subconjunctival Fibroblasts

    Tetsuya Yamamoto;James Varani;H. Kaz Soong;Paul R. Lighter

  • Matrix Metalloproteinase‐1 is the Major Collagenolytic Enzyme Responsible for Collagen Damage in UV‐irradiated Human Skin¶

    Meghan Brennan;Humaa Bhatti;Kamalakar C. Nerusu;Narasimharao Bhagavathula

  • Inhibition of Type I Procollagen Synthesis by Damaged Collagen in Photoaged Skin and by Collagenase-Degraded Collagen in Vitro

    James Varani;Dara Spearman;Patricia Perone;Suzanne E.G. Fligiel

  • Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical.

    J. Varani;S. E G Fligiel;G. O. Till;R. G. Kunkel

  • Improvement of naturally aged skin with vitamin A (Retinol)

    Reza Kafi;Reza Kafi;Heh Shin R. Kwak;Heh Shin R. Kwak;Wendy E. Schumacher;Soyun Cho;Soyun Cho

  • Collagen degradation in aged/photodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro.

    Suzanne E.G. Fligiel;James Varani;Subhash C. Datta;Sewon Kang

  • Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells.

    Muhammad Nadeem Aslam;Ephraim Philip Lansky;James Varani

  • Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis

    Brian J. Nickoloff;Raj S. Mitra;James Varani;Vishva M. Dixit

  • Troglitazone Improves Psoriasis and Normalizes Models of Proliferative Skin Disease: Ligands for Peroxisome Proliferator-Activated Receptor-γ Inhibit Keratinocyte Proliferation

    Charles N. Ellis;James Varani;Gary J. Fisher;Mary E. Zeigler

  • Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor‐stimulated human epidermal keratinocytes

    Mary E. Zeigler;Yiqing Chi;Tanja Schmidt;James Varani

  • Endothelial cell killing by neutrophils. Synergistic interaction of oxygen products and proteases.

    J. Varani;I. Ginsburg;L. Schuger;D. F. Gibbs

Frequent Co-Authors

Kent J. Johnson
Kent J. Johnson University of Michigan–Ann Arbor
John J. Voorhees
John J. Voorhees University of Michigan–Ann Arbor
Peter A. Ward
Peter A. Ward University of Michigan–Ann Arbor
Gary J. Fisher
Gary J. Fisher University of Michigan–Ann Arbor
Brian J. Nickoloff
Brian J. Nickoloff Loyola University Chicago
Irwin J. Goldstein
Irwin J. Goldstein University of Michigan–Ann Arbor
James T. Elder
James T. Elder University of Michigan–Ann Arbor
Thomas E. Carey
Thomas E. Carey University of Michigan–Ann Arbor
Charles N. Ellis
Charles N. Ellis University of Michigan–Ann Arbor

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry in the USA can open doors to a wide range of online degree options and career pathways within the healthcare and sciences field. Those interested in medical imaging may consider radiology tech online programs, which offer flexible learning and can lead to high-demand roles in diagnostic technology.

Nutrition and wellness are also growing fields. For students seeking advanced expertise, accredited dietetic masters programs provide the knowledge needed for careers as registered dietitians or nutritionists. These programs often build upon foundational biology and biochemistry studies.

For those drawn to patient care, starting as a clinical assistant is a popular option. Accredited medical assistant programs are widely available online and often come with financial aid, making them accessible to many students. If you’re looking to advance, an ma to lpn bridge program online can help you move from a medical assistant role to a Licensed Practical Nurse (LPN) position.

Choosing an online pathway allows for the balance of work, study, and personal commitments, making it easier than ever to start or advance a career in the life sciences or healthcare.

Best Scientists Citing James Varani

Trending Scientists

Recently Published Articles