World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
122
Citations
99245
World Ranking
3392
National Ranking
1865

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Timothy A. Chan is affiliated with the Cleveland Clinic in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on Oncology, Immunology, Pulmonary and Respiratory Medicine, Molecular Biology, and Cancer Research as prominent subfields of study.

The main topics covered in their work include:

  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Immunotherapy and Immune Responses
  • Renal cell carcinoma treatment
  • Ferroptosis and cancer prognosis
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research

Timothy A. Chan has contributed to multiple scientific publications with several notable papers including:

  • Consensus guidelines for the definition, detection and interpretation of immunogenic cell death, 2020, Journal for ImmunoTherapy of Cancer
  • Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors, 2021, Nature Communications
  • Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy, 2021, Cancer Cell
  • COVID-19 and Cardiovascular Disease, 2021, Circulation Research
  • Real-world application of tumor mutational burden-high (TMB-high) and microsatellite instability (MSI) confirms their utility as immunotherapy biomarkers, 2021, ESMO Open

The scientist has frequently published in several venues, most prominently:

  • bioRxiv (Cold Spring Harbor Laboratory) with 15 publications
  • Journal of Clinical Oncology with 14 publications
  • Clinical Cancer Research with 9 publications
  • Nature Communications with 8 publications
  • Regular and Young Investigator Award Abstracts with 8 publications

Timothy A. Chan has collaborated extensively with a number of coauthors, including:

  • A. Ari Hakimi (40 collaborations)
  • Fengshen Kuo (37 collaborations)
  • Luc G.T. Morris (27 collaborations)
  • Tyler Alban (26 collaborations)
  • Renzo G. DiNatale (19 collaborations)

Throughout their career, the scientist has been recognized as a Member of the Association of American Physicians.

Best Publications

  • Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

    Naiyer A. Rizvi;Naiyer A. Rizvi;Matthew D. Hellmann;Matthew D. Hellmann;Alexandra Snyder;Alexandra Snyder;Pia Kvistborg

  • Comprehensive molecular characterization of human colon and rectal cancer

    Donna M. Muzny;Matthew N. Bainbridge;Kyle Chang;Huyen H. Dinh

  • Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

    Alexandra Snyder;Vladimir Makarov;Taha Merghoub;Jianda Yuan

  • Comprehensive genomic characterization of head and neck squamous cell carcinomas

    Michael S. Lawrence;Carrie Sougnez;Lee Lichtenstein;Kristian Cibulskis

  • Tumor mutational load predicts survival after immunotherapy across multiple cancer types.

    Robert M Samstein;Chung-Han Lee;Chung-Han Lee;Alexander N Shoushtari;Alexander N Shoushtari;Matthew D Hellmann;Matthew D Hellmann

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    Nicholas McGranahan;Nicholas McGranahan;Andrew J. S. Furness;Rachel Rosenthal;Sofie Ramskov

  • Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

    Daniel J. Brat;Roel G.W. Verhaak;Kenneth D. Aldape;W. K.Alfred Yung

  • Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

    T.A. Chan;M. Yarchoan;E. Jaffee;C. Swanton

  • CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

    Weimin Wang;Michael Green;Jae Eun Choi;Miguel Gijón

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.

    Nadeem Riaz;Jonathan J. Havel;Vladimir Makarov;Alexis Desrichard

  • IDH mutation impairs histone demethylation and results in a block to cell differentiation

    Chao Lu;Patrick S. Ward;Patrick S. Ward;Gurpreet S. Kapoor;Dan Rohle;Dan Rohle

  • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

    Sevin Turcan;Daniel Rohle;Daniel Rohle;Anuj Goenka;Logan A. Walsh

  • Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

    Katherine B. Chiappinelli;Pamela L. Strissel;Alexis Desrichard;Huili Li

  • The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy

    Jonathan J. Havel;Diego Chowell;Timothy A. Chan

  • PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

    Tong Chuan He;Timothy A. Chan;Bert Vogelstein;Kenneth W. Kinzler

  • 14-3-3σ is required to prevent mitotic catastrophe after DNA damage

    Timothy A. Chan;Heiko Hermeking;Christoph Lengauer;Kenneth W. Kinzler

  • An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

    Dan Rohle;Janeta Popovici-Muller;Nicolaos Palaskas;Sevin Turcan

  • Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

    Vinod P. Balachandran;Marta Łuksza;Julia N. Zhao;Vladimir Makarov

  • Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

    Diego Chowell;Luc G. T. Morris;Claud M. Grigg;Jeffrey K. Weber

Frequent Co-Authors

Luc G. T. Morris
Luc G. T. Morris Memorial Sloan Kettering Cancer Center
Vladimir Makarov
Vladimir Makarov Memorial Sloan Kettering Cancer Center
Jedd D. Wolchok
Jedd D. Wolchok Cornell University
Jason T. Huse
Jason T. Huse The University of Texas MD Anderson Cancer Center
Yoshiya Yamada
Yoshiya Yamada Memorial Sloan Kettering Cancer Center
Ian Ganly
Ian Ganly Memorial Sloan Kettering Cancer Center
Robert J. Motzer
Robert J. Motzer Memorial Sloan Kettering Cancer Center
Cameron Brennan
Cameron Brennan Memorial Sloan Kettering Cancer Center
Ingo K. Mellinghoff
Ingo K. Mellinghoff Memorial Sloan Kettering Cancer Center
Taha Merghoub
Taha Merghoub Cornell University

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