World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
104
Citations
55631
World Ranking
1229
National Ranking
728

Overview

Tong-Chuan He is affiliated with the University of Chicago in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine. The scientist's work encompasses a range of subfields including molecular biology, cancer research, surgery, genetics, and biomedical engineering.

The main topics covered in their publications highlight a focus on cancer-related molecular mechanisms, mesenchymal stem cell research, RNA modifications and cancer, 3D printing in biomedical research, tissue engineering and regenerative medicine, epigenetics and DNA methylation, as well as cancer-related gene regulation.

The scientist has contributed to several notable recent papers, including:

  • Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk (2023) in Genes & Diseases
  • Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering (2021) in Frontiers in Bioengineering and Biotechnology
  • Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine (2020) in Frontiers in Bioengineering and Biotechnology
  • The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities (2023) in Genes & Diseases
  • Notch signaling: Its essential roles in bone and craniofacial development (2020) in Genes & Diseases

Collaborations form a significant part of Tong-Chuan He's research output, with frequent co-authors including Russell R. Reid, Hue H. Luu, Jiaming Fan, Rex C. Haydon, and William Wagstaff.

The scientist has been published extensively in several venues, with the most frequent being:

  • Genes & Diseases
  • Pediatric Discovery
  • Research Square (Research Square)
  • Frontiers in Bioengineering and Biotechnology
  • Stem Cells and Development

The accumulation of 129 publications in biochemistry, genetics, and molecular biology, alongside 122 in medicine, reflects a multidisciplinary research approach. Within these broad fields, Tong-Chuan He's work has addressed areas such as molecular biology, cancer mechanisms, biomaterial applications in tissue engineering, and genetic regulation.

Best Publications

  • Identification of c-MYC as a Target of the APC Pathway

    Tong Chuan He;Andrew B. Sparks;Carlo Rago;Heiko Hermeking

  • A simplified system for generating recombinant adenoviruses

    Tong-Chuan He;Bert Vogelstein;Kenneth W. Kinzler

  • 14-3-3σ Is a p53-Regulated Inhibitor of G2/M Progression

    Heiko Hermeking;Christoph Lengauer;Kornelia Polyak;Tong Chuan He

  • PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

    Tong Chuan He;Timothy A. Chan;Bert Vogelstein;Kenneth W. Kinzler

  • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

    Patrick J. Killela;Zachary J. Reitman;Yuchen Jiao;Chetan Bettegowda

  • OSTEOGENIC ACTIVITY OF THE FOURTEEN TYPES OF HUMAN BONE MORPHOGENETIC PROTEINS (BMPS)

    Hongwei Cheng;Wei Jiang;Frank M. Phillips;Rex C. Haydon

  • Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.

    Yixiao Feng;Yixiao Feng;Mia Spezia;Shifeng Huang;Shifeng Huang;Chengfu Yuan;Chengfu Yuan

  • A protocol for rapid generation of recombinant adenoviruses using the AdEasy system

    Jinyong Luo;Zhong Liang Deng;Zhong Liang Deng;Xiaoji Luo;Xiaoji Luo;Ni Tang;Ni Tang

  • Analysis of human transcriptomes

    Victor E Velculescu;Stephen L Madden;Lin Zhang;Alex E Lash

  • Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs).

    Junyi Liao;Qiang Wei;Yulong Zou;Jiaming Fan

  • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.

    Kang Q;Kang Q;Sun Mh;Cheng H;Peng Y

  • The first identification of lysine malonylation substrates and its regulatory enzyme

    Chao Peng;Zhike Lu;Zhongyu Xie;Zhongyi Cheng

  • DISTINCT ROLES OF BONE MORPHOGENETIC PROTEINS IN OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

    Hue H. Luu;Wen Xin Song;Xiaoji Luo;Xiaoji Luo;David Manning

  • Genetic determinants of p53-induced apoptosis and growth arrest.

    Kornelia Polyak;Todd Waldman;Tong Chuan He;Kenneth W. Kinzler

  • 3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends

    Elliot S. Bishop;Sami Mostafa;Mikhail Pakvasa;Hue H. Luu

  • Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine

    Cody S Lee;Elliot S Bishop;Ruyi Zhang;Ruyi Zhang;Xinyi Yu;Xinyi Yu

  • TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL

    Hai Yan;P.J. Killela;Z.J. Reitman;Y. Jiao

  • Regulation of osteogenic differentiation during skeletal development.

    Zhong Liang Deng;Katie A. Sharff;Ni Tang;Ni Tang;Wen Xin Song

  • A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells.

    Quan Kang;Wen-Xin Song;Wen-Xin Song;Qing Luo;Qing Luo;Ni Tang;Ni Tang;Ni Tang

  • Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)1

    H Cheng;W Jiang;F.M Phillips;R.C Haydon

Frequent Co-Authors

Rex C. Haydon
Rex C. Haydon University of Chicago
Hue H. Luu
Hue H. Luu University of Chicago
Yang Bi
Yang Bi Chongqing Medical University
Chun-Su Yuan
Chun-Su Yuan University of Chicago
Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Ailong Huang
Ailong Huang MRC Laboratory of Molecular Biology

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Tong-Chuan He

Trending Scientists