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Immunology

D-Index
95
Citations
55709
World Ranking
871
National Ranking
484

Overview

Taha Merghoub is affiliated with Cornell University in the United States. Their research focuses primarily on the interface of medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Within these broad fields, they have a substantial body of work relating to oncology, immunology, molecular biology, cancer research, and pulmonary and respiratory medicine.

The scientist's main research topics include:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • Cancer, Hypoxia, and Metabolism
  • Cancer Genomics and Diagnostics

Taha Merghoub has published extensively in a range of scientific journals and venues. The most frequent publication venues for their work are:

  • Cancer Research
  • Regular and Young Investigator Award Abstracts
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Journal of Clinical Oncology

Among their recent papers are:

  • "Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer" (2023) published in Nature
  • "Consensus guidelines for the definition, detection and interpretation of immunogenic cell death" (2020) published in Journal for ImmunoTherapy of Cancer
  • "Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways" (2021) published in Nature Reviews Clinical Oncology
  • "Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors" (2021) published in Immunity
  • "CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors" (2020) published in Nature Immunology

The scientist has also contributed to academic books, including the publication "Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer" in 2021 through Frontiers Media.

Frequent co-authors in their research include:

  • Jedd D. Wolchok
  • Sadna Budhu
  • Roberta Zappasodi
  • Levi Mangarin
  • Cailian Liu

Best Publications

  • Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

    Naiyer A. Rizvi;Naiyer A. Rizvi;Matthew D. Hellmann;Matthew D. Hellmann;Alexandra Snyder;Alexandra Snyder;Pia Kvistborg

  • Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

    Alexandra Snyder;Vladimir Makarov;Taha Merghoub;Jianda Yuan

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    Nicholas McGranahan;Nicholas McGranahan;Andrew J. S. Furness;Rachel Rosenthal;Sofie Ramskov

  • Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

    Patrick M. Forde;Jamie E. Chaft;Kellie N. Smith;Valsamo Anagnostou

  • Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

    Katherine B. Chiappinelli;Pamela L. Strissel;Alexis Desrichard;Huili Li

  • Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.

    Hira Rizvi;Francisco Sanchez-Vega;Konnor La;Walid Chatila

  • Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

    Unknown

  • Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

    Vinod P. Balachandran;Marta Łuksza;Julia N. Zhao;Vladimir Makarov

  • Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.

    Matthew D. Hellmann;Tavi Nathanson;Hira Rizvi;Benjamin C. Creelan

  • Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

    Lorenzo Galluzzi;Ilio Vitale;Sarah Warren;Sandy Adjemian

  • Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

    Sergio A. Quezada;Tyler R. Simpson;Karl S. Peggs;Taha Merghoub

  • Chromatin states define tumour-specific T cell dysfunction and reprogramming

    Mary Philip;Lauren Fairchild;Lauren Fairchild;Liping Sun;Ellen L. Horste

  • Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

    Olivier De Henau;Matthew Rausch;David Winkler;Luis Felipe Campesato

  • Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways.

    Lukas Kraehenbuehl;Chien-Huan Weng;Shabnam Eghbali;Jedd D Wolchok

  • Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

    Dmitriy Zamarin;Dmitriy Zamarin;Rikke B. Holmgaard;Rikke B. Holmgaard;Sumit K. Subudhi;Joon Seok Park;Joon Seok Park

  • Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer.

    J.C. Osorio;A. Ni;J.E. Chaft;R. Pollina

  • Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors.

    Shihao Xu;Omkar Chaudhary;Patricia Rodríguez-Morales;Xiaoli Sun

  • A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

    Marta Łuksza;Nadeem Riaz;Vladimir Makarov;Vinod P. Balachandran

  • Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

    Piro Lito;Christine A. Pratilas;Eric W. Joseph;Madhavi Tadi

  • CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

    Haiping Wang;Fabien Franco;Yao Chen Tsui;Xin Xie

  • Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies

    Roberta Zappasodi;Taha Merghoub;Jedd D. Wolchok

  • Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

    Takahiro Maeda;Robin M. Hobbs;Taha Merghoub;Ilhem Guernah

  • Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

    Rikke B. Holmgaard;Dmitriy Zamarin;Yanyun Li;Billel Gasmi

  • Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 152 (974-986))

    Katherine B. Chiappinelli;Pamela L. Strissel;Alexis Desrichard;Huili Li

Frequent Co-Authors

Jedd D. Wolchok
Jedd D. Wolchok Cornell University
Matthew D. Hellmann
Matthew D. Hellmann Memorial Sloan Kettering Cancer Center
Alan N. Houghton
Alan N. Houghton Memorial Sloan Kettering Cancer Center
Stewart Shuman
Stewart Shuman Memorial Sloan Kettering Cancer Center
Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center
Timothy A. Chan
Timothy A. Chan Cleveland Clinic
Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
David B. Solit
David B. Solit Memorial Sloan Kettering Cancer Center
Michael A. Postow
Michael A. Postow Memorial Sloan Kettering Cancer Center
Katherine S. Panageas
Katherine S. Panageas Memorial Sloan Kettering Cancer Center

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