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Chemistry

D-Index
92
Citations
28624
World Ranking
1899
National Ranking
701

Overview

Theodore W. Randolph is affiliated with the University of Colorado Boulder in the United States. Their research spans multiple intersecting fields, including Engineering, Biochemistry, Genetics and Molecular Biology, and Medicine. With a focus on both fundamental and applied aspects, Theodore's work addresses complex challenges in protein science, biotechnology, and immunology.

Their main subfields of study include Molecular Biology, Biomedical Engineering, Infectious Diseases, Immunology, and Epidemiology. This multidisciplinary approach supports investigations into the behavior and stability of biological molecules as well as corresponding technological innovations.

Theodore's research topics are diverse and include:

  • Protein purification and stability
  • Microfluidic and Bio-sensing Technologies
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • Cervical Cancer and HPV Research
  • Mineral Processing and Grinding
  • Viral Infections and Outbreaks Research

Theodore has been published in a variety of scientific journals, with a notable presence in:

  • Journal of Pharmaceutical Sciences (17 publications)
  • Biotechnology and Bioengineering (5 publications)
  • Advanced Drug Delivery Reviews
  • npj Vaccines
  • Biotechnology Journal

Some recent research articles authored or co-authored by Theodore include:

  • "Stability of lyophilized and spray dried vaccine formulations," 2021, Advanced Drug Delivery Reviews
  • "Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology," 2020, npj Vaccines
  • "Machine learning and statistical analyses for extracting and characterizing 'fingerprints' of antibody aggregation at container interfaces from flow microscopy images," 2020, Biotechnology and Bioengineering
  • "Aggregation and Particle Formation During Pumping of an Antibody Formulation Are Controlled by Electrostatic Interactions Between Pump Surfaces and Protein Molecules," 2020, Journal of Pharmaceutical Sciences
  • "Effects of Tubing Type, Operating Parameters, and Surfactants on Particle Formation During Peristaltic Filling Pump Processing of a mAb Formulation," 2020, Journal of Pharmaceutical Sciences

Theodore often collaborates with several researchers, with frequent co-authors including:

  • Christopher P. Calderon (13 joint publications)
  • Robert L. Garcea (10 joint publications)
  • Hans H. Funke (7 joint publications)
  • Alyssa E. Witeof (6 joint publications)
  • David N. Greenblott (5 joint publications)

Best Publications

  • Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation

    Eva Y. Chi;Sampathkumar Krishnan;Theodore W. Randolph;John F. Carpenter

  • Rational design of stable lyophilized protein formulations: some practical advice.

    John F. Carpenter;Michael J. Pikal;Byeong S. Chang;Theodore W. Randolph

  • Water-in-carbon dioxide microemulsions : an environment for hydrophiles including proteins

    Keith P Johnston;K. L. Harrison;M. J. Clarke;S. M. Howdle

  • Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.

    S. D. Allison;Byeong Chang;T. W. Randolph;T. W. Randolph;J. F. Carpenter

  • Overlooking subvisible particles in therapeutic protein products: Gaps that may compromise product quality

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf.

    James A. Searles;James A. Searles;John F. Carpenter;Theodore W. Randolph

  • Rational design of stable lyophilized protein formulations: theory and practice.

    John F. Carpenter;Beyong S. Chang;William Garzon-Rodriguez;Theodore W. Randolph

  • Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor

    Eva Y. Chi;Sampathkumar Krishnan;Brent S. Kendrick;Byeong S. Chang

  • Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

    Narendra B. Bam;Jeffrey L. Cleland;Janet Yang;Mark C. Manning

  • Effects of Tween 20® and Tween 80® on the Stability of Albutropin During Agitation

    Danny K. Chou;Rajesh Krishnamurthy;Theodore W. Randolph;John F. Carpenter

  • Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization

    James A. Searles;James A. Searles;John F. Carpenter;Theodore W. Randolph

  • Solubilization of pharmaceutical substances in an organic solvent and preparation of pharmaceutical powders using the same

    Mark C. Manning;Theodore W. Randolph;Eli Shefter;Richard F. Falk

  • Sub‐Micrometer‐Sized Biodegradable Particles of Poly(L‐Lactic Acid) via the Gas Antisolvent Spray Precipitation Process

    Theodore W. Randolph;Alan D. Randolph;Michael Mebes;Sharon Yeung

  • Enzymatic catalysis in a supercritical fluid

    T. W. Randolph;H. W. Blanch;J. M. Prausnitz;C. R. Wilke

  • Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution

    Renuka Thirumangalathu;Sampathkumar Krishnan;Margaret Speed Ricci;David N. Brems

  • Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII.

    Lotte Kreilgaard;Latoya S. Jones;Latoya S. Jones;Theodore W. Randolph;Sven Frokjaer

  • Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

    Wim Jiskoot;Theodore W. Randolph;David B. Volkin;C. Russell Middaugh

  • Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: Role in restricted conformational mobility and compaction of native state

    Brent S. Kendrick;Byeong S. Chang;Tsutomu Arakawa;Brian Peterson

  • Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • A transient expansion of the native state precedes aggregation of recombinant human interferon-γ

    Brent S. Kendrick;John F. Carpenter;Jeffrey L. Cleland;Theodore W. Randolph

Frequent Co-Authors

John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
Mark C. Manning
Mark C. Manning Colorado State University
Daniel K. Schwartz
Daniel K. Schwartz University of Colorado Boulder
Gerhard Winter
Gerhard Winter Ludwig-Maximilians-Universität München
Robert L. Garcea
Robert L. Garcea University of Colorado Boulder
Yong Sung Kim
Yong Sung Kim Ajou University
Harvey W. Blanch
Harvey W. Blanch University of California, Berkeley
Keith P. Johnston
Keith P. Johnston The University of Texas at Austin
Wim Jiskoot
Wim Jiskoot Leiden University

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