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Chemistry

D-Index
77
Citations
20445
World Ranking
4041
National Ranking
1282

Overview

Michael J. Pikal is affiliated with the University of Connecticut in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with subfields including molecular biology, materials chemistry, mechanics of materials, food science, and pharmaceutical science.

The main topics in Michael J. Pikal's work include:

  • Protein purification and stability
  • Enzyme structure and function
  • Protein structure and dynamics
  • Freezing and crystallization processes
  • Microencapsulation and drying processes
  • Drug solubility and delivery systems
  • Crystallization and solubility studies

Michael J. Pikal has contributed to research published in several scientific venues. These frequent publication venues include:

  • Journal of Pharmaceutical Sciences
  • Pharmaceutical Research
  • AAPS PharmSciTech
  • Proceedings of the 22nd International Drying Symposium on Drying Technology - IDS '22

Notable recent papers by Michael J. Pikal are as follows:

  • Stability of Freeze-Dried Protein Formulations: Contributions of Ice Nucleation Temperature and Residence Time in the Freeze-Concentrate, 2020, Journal of Pharmaceutical Sciences
  • Evaluation of Predictors of Protein Relative Stability Obtained by Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR, 2020, Pharmaceutical Research
  • Recommended Best Practices in Freeze Dryer Equipment Performance Qualification: 2022, 2023, AAPS PharmSciTech
  • Evaluation of a Raman Chemometric Method for Detecting Protein Structural Conformational Changes in Solution, 2022, Journal of Pharmaceutical Sciences
  • Correction to: Evaluation of Predictors of Protein Relative Stability Obtained by Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR, 2021, Pharmaceutical Research

Collaborations have involved frequent co-authors, including Robin H. Bogner, Rui Fang, Steven L. Nail, Wasfy M. Obeidat, and Arnab Ganguly.

Best Publications

  • Design of freeze-drying processes for pharmaceuticals: practical advice.

    Xiaolin (Charlie) Tang;Michael J. Pikal

  • Rational design of stable lyophilized protein formulations: some practical advice.

    John F. Carpenter;Michael J. Pikal;Byeong S. Chang;Theodore W. Randolph

  • Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

    Liuquan Lucy Chang;Deanna Shepherd;Joanna Sun;David Ouellette

  • Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization

    Bakul S. Bhatnagar;Robin H. Bogner;Michael J. Pikal

  • Role of Thermodynamic, Molecular, and Kinetic Factors in Crystallization from the Amorphous State

    Chandan Bhugra;Michael J. Pikal

  • Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis

    Sharad B. Murdande;Sharad B. Murdande;Michael J. Pikal;Ravi M. Shanker;Robin H. Bogner

  • Mass and Heat Transfer in Vial Freeze-Drying of Pharmaceuticals: Role of the Vial

    Michael J Pikal;M L Roy;S Shah

  • The role of electroosmotic flow in transdermal iontophoresis

    Michael J. Pikal

  • CHARACTERIZATION OF THE TIME SCALES OF MOLECULAR MOTION IN PHARMACEUTICALLY IMPORTANT GLASSES

    Sheri L. Shamblin;Xiaolin Tang;Liuquan Chang;Bruno C. Hancock

  • MECHANISMS OF PROTEIN STABILIZATION IN THE SOLID STATE

    Liuquan Lucy Chang;Michael J Pikal

  • The collapse temperature in freeze drying: Dependence on measurement methodology and rate of water removal from the glassy phase

    Michael J. Pikal;Saroj Shah

  • The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone

    Michael J. Pikal;Karen M. Dellerman;Michael L. Roy;Ralph M. Riggin

  • Quantitative Crystallinity Determinations for β-Lactam Antibiotics by Solution Calorimetry: Correlations with Stability

    M.J. Pikal;A.L. Lukes;John E. Lang;K. Gaines

  • The secondary drying stage of freeze drying: drying kinetics as a function of temperature and chamber pressure☆

    M.J. Pikal;S. Shah;M.L. Roy;R. Putman

  • Determination of End Point of Primary Drying in Freeze-Drying Process Control

    Sajal M. Patel;Takayuki Doen;Takayuki Doen;Michael J. Pikal

  • Apparent Molal Volumes of Some Aqueous Rare Earth Chloride and Nitrate Solutions at 25°1

    F. H. Spedding;M. J. Pikal;B. O. Ayers

  • Use of laboratory data in freeze drying process design: heat and mass transfer coefficients and the computer simulation of freeze drying.

    Pikal Mj

  • Heat and mass transfer scale-up issues during freeze drying: II. Control and characterization of the degree of supercooling

    Shailaja Rambhatla;Roee Ramot;Chandan Bhugra;Michael J. Pikal

  • Physical Chemistry of Freeze-drying: Measurement of Sublimation Rates for Frozen Aqueous Solutions by a Microbalance Technique

    M.J. Pikal;S. Shah;D. Senior;J.E. Lang

  • Freeze-drying process design by manometric temperature measurement: design of a smart freeze-dryer.

    Xiaolin Charlie Tang;Steven L Nail;Steven L Nail;Michael J Pikal

  • The Stability of Insulin in Crystalline and Amorphous Solids: Observation of Greater Stability for the Amorphous Form

    Michael J. Pikal;Daniel R. Rigsbee

Frequent Co-Authors

John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
Marcus T. Cicerone
Marcus T. Cicerone National Institute of Standards and Technology
Bruno C. Hancock
Bruno C. Hancock Pfizer (United States)
Theodore W. Randolph
Theodore W. Randolph University of Colorado Boulder
Lynne S. Taylor
Lynne S. Taylor Purdue University West Lafayette
Christopher J. Roberts
Christopher J. Roberts University of Delaware
Gerhard Winter
Gerhard Winter Ludwig-Maximilians-Universität München
J. Axel Zeitler
J. Axel Zeitler University of Cambridge
Elena V. Boldyreva
Elena V. Boldyreva Novosibirsk State University
Alan K. Soper
Alan K. Soper Rutherford Appleton Laboratory

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