D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 74 Citations 19,782 418 World Ranking 2749 National Ranking 1013

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Biochemistry
  • Internal medicine

His primary areas of study are Chromatography, Solubility, Dissolution, Membrane and Stratum corneum. The various areas that William I. Higuchi examines in his Chromatography study include Boundary layer, Permeation, Aqueous solution and Diffusion. His Permeation study combines topics in areas such as Hairless, Ethanol and Mannitol.

His Solubility research incorporates elements of Crystallinity, Chemical engineering, Carbonate and Solvent. His Dissolution research is multidisciplinary, relying on both Inorganic chemistry, Sulfathiazole, Cholesterol, Phosphate and Kinetics. The concepts of his Stratum corneum study are interwoven with issues in Prodrug, Biophysics, Dermis and Permeability.

His most cited work include:

  • Analysis of data on the medicament release from ointments. (525 citations)
  • Dissolution Rates of High Energy Polyvinylpyrrolidone (PVP)-Sulfathiazole Coprecipitates (272 citations)
  • Release of medroxyprogesterone acetate from a silicone polymer. (256 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Chromatography, Dissolution, Membrane, Solubility and Aqueous solution. His Chromatography research integrates issues from Hexadecane, Micelle and Permeation. The Permeation study combines topics in areas such as Absorption and Stratum corneum.

His research integrates issues of Inorganic chemistry, Cholesterol, Mineralogy and Kinetics in his study of Dissolution. His work on Permeability, Synthetic membrane and Membrane transport as part of general Membrane study is frequently linked to Iontophoresis, bridging the gap between disciplines. His Aqueous solution study integrates concerns from other disciplines, such as Electrolyte and Diffusion layer.

He most often published in these fields:

  • Chromatography (23.73%)
  • Dissolution (22.03%)
  • Membrane (16.53%)

What were the highlights of his more recent work (between 1998-2020)?

  • Iontophoresis (11.23%)
  • Permeation (11.65%)
  • Solubility (15.04%)

In recent papers he was focusing on the following fields of study:

His main research concerns Iontophoresis, Permeation, Solubility, Biophysics and Analytical chemistry. His research on Permeation also deals with topics like

  • Stratum corneum which is related to area like Partition coefficient and Lipid bilayer,
  • Hairless, which have a strong connection to Azone. His studies deal with areas such as Inorganic chemistry, Dissolution, Phosphate, Apatite and Aqueous solution as well as Solubility.

His studies in Dissolution integrate themes in fields like Equilibrium constant, Stoichiometry and Calcium. William I. Higuchi studied Analytical chemistry and Electro-osmosis that intersect with Charge density. His study in Permeability is interdisciplinary in nature, drawing from both Chromatography and Diffusion.

Between 1998 and 2020, his most popular works were:

  • Relationships among carbonated apatite solubility, crystallite size, and microstrain parameters. (156 citations)
  • Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis (102 citations)
  • Osteotropic peptide that differentiates functional domains of the skeleton (76 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Biochemistry
  • Internal medicine

William I. Higuchi mainly focuses on Permeation, Iontophoresis, Stratum corneum, Analytical chemistry and Enhancer. The concepts of his Permeation study are interwoven with issues in Hairless, Biophysics, Permeability, Aqueous solution and Solubility. His Solubility study incorporates themes from Inorganic chemistry, Dissolution, Octacalcium phosphate, Phosphate and Crystallinity.

His Stratum corneum research includes elements of Partition coefficient and Chromatography. Much of his study explores Chromatography relationship to Absorption. The study incorporates disciplines such as Electrolyte, Tetraethylammonium and Diffusion in addition to Analytical chemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Analysis of data on the medicament release from ointments.

W.I. Higuchi.
Journal of Pharmaceutical Sciences (1962)

834 Citations

Dissolution Rates of High Energy Polyvinylpyrrolidone (PVP)-Sulfathiazole Coprecipitates

A.P. Simonelli;S.C. Mehta;W.I. Higuchi.
Journal of Pharmaceutical Sciences (1969)

440 Citations

Diffusional Models Useful in Biopharmaceutics: Drug Release Rate Processes

William I. Higuchi.
Journal of Pharmaceutical Sciences (1967)

401 Citations

Release of medroxyprogesterone acetate from a silicone polymer.

T.J. Roseman;W.I. Higuchi.
Journal of Pharmaceutical Sciences (1970)

385 Citations

Physical degradation of emulsions via the molecular diffusion route and the possible prevention thereof

W.I. Higuchi;Jagdish Misra.
Journal of Pharmaceutical Sciences (1962)

342 Citations

Investigation of factors influencing release of solid drug dispersed in inert matrices.

S.J. Desai;A.P. Simonelli;W.I. Higuchi.
Journal of Pharmaceutical Sciences (1966)

336 Citations

Drug release from wax matrices. I. Analysis of data with first-order kinetics and with the diffusion-controlled model.

Joseph B. Schwartz;Anthony P. Simonelli;William I. Higuchi.
Journal of Pharmaceutical Sciences (1968)

331 Citations

Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes

I. Komiya;J.Y. Park;A. Kamani;N.F.H. Ho.
International Journal of Pharmaceutics (1980)

310 Citations

Polymorphism and drug availability. Solubility relationships in the methylprednisolone system

W.I. Higuchi;P.K. Lau;T. Higuchi;J.W. Shell.
Journal of Pharmaceutical Sciences (1963)

290 Citations

Permeation of hairless mouse skin I: Experimental methods and comparison with human epidermal permeation by alkanols

Hugo Durrheim;Gordon L. Flynn;William I. Higuchi;Charan R. Behl.
Journal of Pharmaceutical Sciences (1980)

288 Citations

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