World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
10621
World Ranking
16619
National Ranking
277

Overview

Frederik J. Hes is affiliated with the Vrije Universiteit Brussel in Belgium. Their research spans multiple disciplines primarily within Medicine and Biochemistry, Genetics and Molecular Biology, emphasizing human health and disease.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

More specifically, their work addresses subfields such as Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health, Molecular Biology, Genetics, and Reproductive Medicine.

Research topics frequently covered by Frederik J. Hes encompass areas related to reproductive health and genetics, including:

  • Assisted Reproductive Technology and Twin Pregnancy
  • Reproductive Biology and Fertility
  • Prenatal Screening and Diagnostics
  • Reproductive Health and Technologies
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • Genomics and Rare Diseases

Recent publications showcase their involvement in cancer genetics, reproductive medicine, and genetic disorders. Selected recent papers include:

  • Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study, 2021, The Lancet Oncology
  • Disease expression in juvenile polyposis syndrome: a retrospective survey on a cohort of 221 European patients and comparison with a literature-derived cohort of 473 SMAD4/BMPR1A pathogenic variant carriers, 2020, Genetics in Medicine
  • Duodenal Adenomas and Cancer in MUTYH-associated Polyposis: An International Cohort Study, 2020, Gastroenterology
  • Chromosomal abnormalities after ICSI in relation to semen parameters: results in 1114 fetuses and 1391 neonates from a single center, 2020, Human Reproduction
  • A systematic review and evidence assessment of monogenic gene-disease relationships in human female infertility and differences in sex development, 2022, Human Reproduction Update

Frederik J. Hes frequently publishes in venues such as Human Reproduction, European Journal of Human Genetics, Human Reproduction Open, bioRxiv (Cold Spring Harbor Laboratory), and The Journal of Clinical Endocrinology & Metabolism.

Collaboration is an important element of their career, with frequent co-authors including Kathelijn Keymolen, Annelore Van Der Kelen, Willem Verpoest, Florence Belva, and Herman Tournaye. These partnerships suggest a strong focus on genetics, reproductive medicine, and related fields within their research network.

Best Publications

  • Peutz–Jeghers syndrome: a systematic review and recommendations for management

    A. D. Beggs;A. R. Latchford;H. F. A. Vasen;G. Moslein

  • Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

    Hans F.A. Vasen;Gabriele Möslein;Angel Alonso;Inge Bernstein

  • MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma

    Nelly Burnichon;Alberto Cascón;Francesca Schiavi;Nicole Paes Morales

  • Risks of Less Common Cancers in Proven Mutation Carriers With Lynch Syndrome

    Christoph Engel;Markus Loeffler;Verena Steinke;Nils Rahner

  • Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study

    Marlies J E Kempers;Roland P Kuiper;Charlotte W Ockeloen;Pierre O Chappuis

  • SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

    Jean Pierre Bayley;Henricus P.M. Kunst;Alberto Cascon;Maria Lourdes Sampietro

  • Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP)

    M Nielsen;P F Franken;T H C M Reinards;M M Weiss

  • Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer

    Tjalling Bosse;Natalja T ter Haar;Laura M Seeber;Paul J v Diest

  • Lynch Syndrome Caused by Germline PMS2 Mutations: Delineating the Cancer Risk

    Sanne W. ten Broeke;Richard M. Brohet;Carli M. Tops;Heleen M. van der Klift

  • MUTYH-associated polyposis (MAP)

    Maartje Nielsen;Hans Morreau;Hans F.A. Vasen;Frederik J. Hes

  • Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis.

    M Nielsen;F J Hes;F M Nagengast;M M Weiss

  • Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation.

    Hans F.A. Vasen;Martin Wasser;Anneke van Mil;Rob A. Tollenaar

  • Cancer Risks for PMS2-Associated Lynch Syndrome

    Sanne W Ten Broeke;Heleen M van der Klift;Carli M J Tops;Stefan Aretz

  • Risk of malignant paraganglioma in SDHB-mutation and SDHD-mutation carriers: a systematic review and meta-analysis

    Leonie Theresia van Hulsteijn;Olaf M Dekkers;Frederik J Hes;Jan W A Smit

  • Cancer risk and genotype-phenotype correlations in PTEN hamartoma tumor syndrome.

    Marry H. Nieuwenhuis;C. Marleen Kets;Maureen Murphy-Ryan;Helger G. Yntema

  • Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

    Judith E. Grolleman;Richarda M. de Voer;Fadwa A. Elsayed;Maartje Nielsen

  • Increased Colorectal Cancer Incidence in Obligate Carriers of Heterozygous Mutations in MUTYH

    Natalie Jones;Stefanie Vogt;Maartje Nielsen;Daria Christian

  • Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.

    Fadwa A Elsayed;C Marleen Kets;Dina Ruano;Brendy van den Akker

  • Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers

    Anne M. L. Jansen;Tom van Wezel;Brendy E. W. M. van den Akker;Marina Ventayol Garcia

  • Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.

    Juul T. Wijnen;Richard M. Brohet;Ronald Van Eijk;Shanty Jagmohan-Changur

Frequent Co-Authors

Hans F. A. Vasen
Hans F. A. Vasen Leiden University
Juul T. Wijnen
Juul T. Wijnen Leiden University Medical Center
Tom van Wezel
Tom van Wezel Leiden University Medical Center
Hans Morreau
Hans Morreau Leiden University Medical Center
Rolf H. Sijmons
Rolf H. Sijmons University of Groningen
Peter Devilee
Peter Devilee Leiden University Medical Center
Julian Roy Sampson
Julian Roy Sampson Cardiff University
Gabriel Capellá
Gabriel Capellá Institut d'Investigació Biomédica de Bellvitge
Pål Møller
Pål Møller Oslo University Hospital
Fred H. Menko
Fred H. Menko Netherlands Cancer Institute

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