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Molecular Biology

D-Index
57
Citations
10754
World Ranking
2157
National Ranking
50

Overview

Tom van Wezel is affiliated with Leiden University Medical Center in the Netherlands, specializing in research at the intersection of medicine, biochemistry, genetics, and molecular biology. Their work spans several key fields of study, notably pathology and forensic medicine, cancer research, oncology, genetics, and pulmonary and respiratory medicine.

Their research contributions focus predominantly on cancer genomics and diagnostics, addressing genetic factors in colorectal cancer, lymphoma diagnosis and treatment, BRCA gene mutations in cancer, and studies related to colorectal and lung cancer treatments, as well as ovarian cancer diagnosis and treatment.

Tom van Wezel's recent publications illustrate the scope and detail of their research. Key papers include:

  • "Optimizing Mutation and Fusion Detection in NSCLC by Sequential DNA and RNA Sequencing," 2020, Journal of Thoracic Oncology
  • "Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing," 2020, Leukemia
  • "Prevalence and Prognosis of Lynch Syndrome and Sporadic Mismatch Repair Deficiency in Endometrial Cancer," 2021, JNCI Journal of the National Cancer Institute
  • "IGLV3-21 *01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling," 2020, Proceedings of the National Academy of Sciences
  • "Germline MBD4 deficiency causes a multi-tumor predisposition syndrome," 2022, The American Journal of Human Genetics

Their collaborations reflect sustained partnerships with frequent coauthors including Maartje Nielsen, Hans Morreau, Dina Ruano, Diantha Terlouw, and Carli M.J. Tops, highlighting a networked approach to cancer and molecular genetic research.

Major publication venues where Tom van Wezel's work frequently appears are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Modern Pathology
  • Cancers
  • Blood
  • Annals of Oncology

Tom van Wezel has contributed extensively to understanding the complexities of genetic mutations and their impact on various cancers. Their research methodology often integrates cutting-edge sequencing technologies to enhance diagnostic precision and expand knowledge on hereditary risk factors and tumor predisposition syndromes. This multidisciplinary focus supports advancements across oncology, molecular diagnostics, and genetics, maintaining a strong clinical relevance within Leiden University Medical Center's medical research framework.

Best Publications

  • A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

    Ian P.M. Tomlinson;Emily Webb;Luis Carvajal-Carmona;Peter Broderick

  • Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

    Twinkal C. Pansuriya;Ronald van Eijk;Pio d'Adamo;Maayke A. J. H. van Ruler

  • E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines

    M. Lombaerts;T. Van Wezel;K. Philippo;J. W. F. Dierssen

  • Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

    Jarno Drost;Ruben van Boxtel;Francis Blokzijl;Tomohiro Mizutani

  • Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.

    Claudia A.L. Ruivenkamp;Tom van Wezel;Carlo Zanon;Alphons P.M. Stassen

  • Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

    Enric Domingo;Enric Domingo;Luke Freeman-Mills;Emily Rayner;Mark Glaire

  • A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 ( REL ), 8q24.21 and 10p14 ( GATA3 )

    Victor Enciso-Mora;Peter Broderick;Yussanne Ma;Ruth F. Jarrett

  • Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.

    Ronald van Eijk;Jappe Licht;Melanie Schrumpf;Mehrdad Talebian Yazdi

  • Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

    Philip W. Voorneveld;Liudmila L. Kodach;Rutger J. Jacobs;Nalan Liv

  • Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway

    Liudmila L Kodach;Rutger J Jacobs;Philip W Voorneveld;Manon E Wildenberg

  • Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

    Judith E. Grolleman;Richarda M. de Voer;Fadwa A. Elsayed;Maartje Nielsen

  • Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.

    Judith N Kloth;Jan Oosting;Tom van Wezel;Karoly Szuhai

  • Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.

    Fadwa A Elsayed;C Marleen Kets;Dina Ruano;Brendy van den Akker

  • Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.

    Marlies S. Reimers;Esther Bastiaannet;Ruth E. Langley;Ronald van Eijk

  • Genomic Characterization of Vulvar (Pre)cancers Identifies Distinct Molecular Subtypes with Prognostic Significance.

    Linda S. Nooij;Natalja T. ter Haar;Dina Ruano;Natalia Rakislova

  • Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers

    Anne M. L. Jansen;Tom van Wezel;Brendy E. W. M. van den Akker;Marina Ventayol Garcia

  • HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression

    Jan Willem F Dierssen;Noel F C C de Miranda;Soldano Ferrone;Marjo van Puijenbroek

  • The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression

    Alan M. Pittman;Silvia Naranjo;Emily Webb;Peter Broderick

  • Reliable high-throughput genotyping and loss-of-heterozygosity detection in formalin-fixed, paraffin-embedded tumors using single nucleotide polymorphism arrays.

    Esther H. Lips;Jan Willem F. Dierssen;Ronald van Eijk;Jan Oosting

  • Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas

    C. J. Haven;M. van Puijenbroek;M. H. Tan;B. T. Teh

Frequent Co-Authors

Hans Morreau
Hans Morreau Leiden University Medical Center
Frederik J. Hes
Frederik J. Hes Vrije Universiteit Brussel
Juul T. Wijnen
Juul T. Wijnen Leiden University Medical Center
Hans F. A. Vasen
Hans F. A. Vasen Leiden University
Ian Tomlinson
Ian Tomlinson University of Oxford
Sergi Castellví-Bel
Sergi Castellví-Bel Clínic Barcelona
Richard S. Houlston
Richard S. Houlston Institute of Cancer Research
Judith V.M.G. Bovée
Judith V.M.G. Bovée Leiden University Medical Center
Cornelis J.H. van de Velde
Cornelis J.H. van de Velde Leiden University Medical Center
Antoni Castells
Antoni Castells University of Barcelona

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