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D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
14510
World Ranking
5760
National Ranking
207

Research.com Recognitions

  • 1994 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Robert Day is affiliated with the Université de Sherbrooke in Canada and contributes to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research encompasses several subfields including Molecular Biology, Pulmonary and Respiratory Medicine, Cell Biology, Epidemiology, and Organic Chemistry.

The main topics covered in Robert Day's work include:

  • Ubiquitin and proteasome pathways
  • Prostate cancer treatment and research
  • Receptor mechanisms and signaling
  • Cancer-related gene regulation
  • Protein degradation and inhibitors
  • Cellular transport and secretion
  • Endoplasmic reticulum stress and disease

Frequent co-authors in Day's research include Anna Kwiatkowska, Frédéric Couture, Roxane Desjardins, Alexandra Evagelidis, and Johann Guillemot.

Day has published in a variety of scientific journals, with multiple contributions to the Journal of Biological Chemistry and Scientific Reports, as well as publications in ACS Medicinal Chemistry Letters, Canadian Journal of Physiology and Pharmacology, and Molecular Pharmaceutics.

Their recent papers demonstrate a focus on protein processing, enzyme inhibition, and biomarker discovery, including:

  • The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity, 2020, Journal of Biological Chemistry
  • Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin, 2021, ACS Medicinal Chemistry Letters
  • PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer, 2022, Scientific Reports
  • Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I, 2020, Journal of Pharmacology and Experimental Therapeutics
  • Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors, 2020, Canadian Journal of Physiology and Pharmacology

Robert Day's research has relevance across multiple disciplines, focusing on molecular mechanisms underlying cancer biology and cellular regulatory pathways. Their work combines biochemical approaches with medical applications, particularly in areas such as prostate cancer and protease function.

In 1994, Day was elected Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

    S Benjannet;N Rondeau;R Day;M Chrétien

  • The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.

    N.G. Seidah;M. Chrétien;R. Day

  • Direct analysis and MALDI imaging of formalin-fixed, paraffin-embedded tissue sections.

    Lemaire R;Desmons A;Tabet Jc;Day R

  • Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation EVIDENCE FOR AN INTRACELLULAR ROUTE

    Steve Poirier;Gaetan Mayer;Viviane Poupon;Peter S. McPherson

  • Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary.

    Robert Day;Martin K.H. Schafer;Stanley J. Watson;Michel Chrétien

  • cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells

    J Lusson;D Vieau;J Hamelin;R Day

  • cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.

    N G Seidah;J Hamelin;M Mamarbachi;W Dong

  • Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis

    M. K.-H. Schäfer;R. Day;W. E. Cullinan;M. Chretien

  • Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.

    N G Seidah;R Day;J Hamelin;A Gaspar

  • MALDI-MS Direct Tissue Analysis of Proteins: Improving Signal Sensitivity Using Organic Treatments

    R. Lemaire;M. Wisztorski;A. Desmons;J. C. Tabet

  • MALDI Imaging of Formalin-Fixed Paraffin-Embedded Tissues: Application to Model Animals of Parkinson Disease for Biomarker Hunting

    J. Stauber;R. Lemaire;J. Franck;D. Bonnel

  • Prodynorphin Processing by Proprotein Convertase 2 CLEAVAGE AT SINGLE BASIC RESIDUES AND ENHANCED PROCESSING IN THE PRESENCE OF CARBOXYPEPTIDASE ACTIVITY

    Robert Day;Claude Lazure;Ajoy Basak;Alain Boudreault

  • MALDI imaging mass spectrometry: state of the art technology in clinical proteomics.

    Julien Franck;Karim Arafah;Mohamed Elayed;David Bonnel

  • TGFbeta1 regulates gene expression of its own converting enzyme furin.

    F Blanchette;R Day;W Dong;M H Laprise

  • Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome

    Lisa C. Burnett;Charles A. LeDuc;Carlos R. Sulsona;Daniel Paull

  • Substrate cleavage analysis of furin and related proprotein convertases: A comparative study

    Albert G. Remacle;Sergey A. Shiryaev;Eok Soo Oh;Piotr Cieplak

  • Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin

    M Marcinkiewicz;R Day;N G Seidah;M Chrétien

  • Proteolytic processing of Angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on Lipoprotein Lipase activity

    Xia Lei;Fujun Shi;Debapriya Basu;Afroza Huq

  • Laser Microprobe Mass Spectrometry 2. Applications to Structural Analysis

    David M. Hercules;R. J. Day;K. Balasanmugam;Tuan A. Dang

  • TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity.

    Nadim Srour;Annie Lebel;Stephanie McMahon;Isabelle Fournier

Frequent Co-Authors

Michel Salzet
Michel Salzet University of Lille
Nabil G. Seidah
Nabil G. Seidah University of Montreal
Iris Lindberg
Iris Lindberg University of Maryland, Baltimore
Annik Prat
Annik Prat University of Montreal
Michel Chrétien
Michel Chrétien University of Montreal
Alex Y. Strongin
Alex Y. Strongin Sanford Burnham Prebys Medical Discovery Institute
Claude Lazure
Claude Lazure University of Montreal
Gunnar Pejler
Gunnar Pejler Uppsala University
Lloyd D. Fricker
Lloyd D. Fricker Albert Einstein College of Medicine
Martin K.-H. Schäfer
Martin K.-H. Schäfer Philipp University of Marburg

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