Vivian Hook

Overview

Best Publications

• The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

  Francine E. Garrett-Bakelman;Francine E. Garrett-Bakelman;Manjula Darshi;Stefan J. Green;Ruben C. Gur

  1121
  Citations

• Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

  E Hermel;E Hermel;J Gafni;S S Propp;B R Leavitt

  290
  Citations

• Proteases for Processing Proneuropeptides into Peptide Neurotransmitters and Hormones

  Vivian Hook;Lydiane Funkelstein;Douglas Lu;Steven Bark

  286
  Citations

• Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

  Vivian Y. H. Hook;Mark Kindy;Gregory Hook

  266
  Citations

• Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter

  Sukkid Yasothornsrikul;Doron Greenbaum;Katalin F. Medzihradszky;Thomas Toneff

  248
  Citations

• Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease

  Vivian Hook;Thomas Toneff;Matthew Bogyo;Doron Greenbaum

  226
  Citations

• Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum

  Liane M. Mende-Mueller;Thomas Toneff;Thomas Toneff;Shin-Rong Hwang;Shin-Rong Hwang;Marie-Francoise Chesselet

  222
  Citations

• A carboxypeptidase processing enzyme for enkephalin precursors

  Vivian Y. H. Hook;Lee E. Eiden;Michael J. Brownstein

  200
  Citations

• Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary

  V Y Hook;Y P Loh

  196
  Citations

• Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.

  Seymour Heisler;Terry D. Reisine;Vivian Y. H. Hook;Julius Axelrod

  169
  Citations

• Proteases and the emerging role of protease inhibitors in prohormone processing.

  V. Y. H. Hook;A. V. Azaryan;Shin-Rong Hwang;N. Tezapsidis

  153
  Citations

• Corticotropin releasing factor stimulates adrenocorticotropin and β-endorphin release from AtT-20 mouse pituitary tumor cells

  Vivian Y.H. Hook;Seymour Heisler;Steven L. Sabol;Julius Axelrod

  138
  Citations

• The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.

  Gregory Hook;Vivian Hook;Mark Kindy;Mark Kindy

  136
  Citations

• Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

  Vivian Y.H. Hook;Mark Kindy;Thomas Reinheckel;Christoph Peters

  127
  Citations

• Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons.

  Vivian Hook;Vivian Hook;Kristen J. Brennand;Yongsung Kim;Thomas Toneff

  122
  Citations

• Cathepsin B in Neurodegeneration of Alzheimer’s Disease, Traumatic Brain Injury, and Related Brain Disorders

  Vivian Hook;Vivian Hook;Michael Yoon;Charles Mosier;Gen Ito

  118
  Citations

• Cathepsin B is a New Drug Target for Traumatic Brain injury Therapeutics: evidence for e64d as a Promising Lead Drug Candidate

  Gregory Hook;J. Steven Jacobsen;Kenneth Grabstein;Mark Kindy;Mark Kindy

  114
  Citations

• Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease.

  Vivian Hook;Israel Schechter;Hans-Ulrich Demuth;Gregory Hook

  109
  Citations

• Expansion of the mycobacterial “PUPylome”

  Jeramie Watrous;Kristin Burns;Wei-Ting Liu;Anand Patel

  105
  Citations

• MAJOR ROLE OF CATHEPSIN L FOR PRODUCING THE PEPTIDE HORMONES ACTH, β-ENDORPHIN, AND α-MSH, ILLUSTRATED BY PROTEASE GENE KNOCKOUT AND EXPRESSION

  Lydiane Funkelstein;Thomas Toneff;Charles Mosier;Shin-Rong Hwang

  105
  Citations