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Biology and Biochemistry

D-Index
69
Citations
13316
World Ranking
7569
National Ranking
3440

Research.com Recognitions

  • 1988 - Fellow of Alfred P. Sloan Foundation

Overview

Lloyd D. Fricker is a researcher affiliated with the Albert Einstein College of Medicine in the United States. Their scholarly work spans multiple disciplines, primarily focusing on biochemistry, genetics, molecular biology, neuroscience, and medicine. Within these fields, they have contributed extensively to molecular biology and cellular and molecular neuroscience.

The main research topics addressed by Lloyd D. Fricker include:

  • Neuropeptides and animal physiology
  • Peptidase inhibition and analysis
  • Receptor mechanisms and signaling
  • Regulation of appetite and obesity
  • Advanced proteomics techniques and applications
  • Chemical synthesis and analysis
  • Ubiquitin and proteasome pathways

Their recent publications illustrate an emphasis on opioid peptides, neuropeptidomic techniques, and receptor function. Notable papers include:

  • "Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions" (2020) published in Molecular Pharmacology
  • "Neuropeptidomic Analysis of a Genetically Defined Cell Type in Mouse Brain and Pituitary" (2020) published in Cell Chemical Biology

Lloyd D. Fricker has collaborated frequently with several researchers, including Lakshmi A. Devi, Ivone Gomes, Amanda K. Fakira, Achla Gupta, and Alexandre K. Tashima.

Their research is regularly published in venues such as Methods in Molecular Biology and Molecular Pharmacology, reflecting a focus on biochemical and pharmacological approaches. Other publication venues include Endocrinology and Cell Chemical Biology.

In recognition of their academic contributions, Lloyd D. Fricker was awarded the title of Fellow of the Alfred P. Sloan Foundation in 1988.

Best Publications

  • Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

    Jürgen K. Naggert;Lloyd D. Fricker;Oleg Varlamov;Patsy M. Nishina

  • Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules.

    Lloyd D. Fricker;Solomon H. Snyder

  • Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase.

    L D Fricker;S H Snyder

  • Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing.

    Lloyd D. Fricker;Audra A. McKinzie;Jilin Sun;Eileen Curran

  • Cloning and sequence analysis of cDNA for bovine carboxypeptidase E.

    Lloyd D. Fricker;Chris J. Evans;Fred S. Esch;Edward Herbert

  • Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing.

    Lloyd D. Fricker;Yemiliya L. Berman;Edward H. Leiter;Lakshmi A. Devi

  • Quantitative neuropeptidomics of microwave-irradiated mouse brain and pituitary

    Fa Yun Che;Jihyeon Lim;Hui Pan;Reeta Biswas

  • Purification and Characterization of Carboxypeptidase D, a Novel Carboxypeptidase E-like Enzyme, from Bovine Pituitary

    Lixin Song;Lloyd D. Fricker

  • Carboxypeptidases from A to z: implications in embryonic development and Wnt binding.

    S.E. Reznik;L.D. Fricker

  • Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10)

    L. D. Fricker;Banasree Das;R. H. Angeletti

  • Novel endogenous peptide agonists of cannabinoid receptors

    Ivone Gomes;Julia S. Grushko;Urszula Golebiewska;Sascha Hoogendoorn

  • Identification of peptides from brain and pituitary of Cpefat/Cpefat mice

    Fa Yun Che;Lin Yan;Lin Yan;Hong Li;Nino Mzhavia

  • Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins

    Lloyd D. Fricker

  • The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1.

    Yimei Qian;Lakshmi A. Devi;Nino Mzhavia;Scott Munzer

  • Quantitative peptidomics of mouse pituitary: comparison of different stable isotopic tags.

    Fa Yun Che;Lloyd D. Fricker

  • Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: localization to the trans-Golgi network and recycling from the cell surface

    Oleg Varlamov;Lloyd D. Fricker

  • Metallocarboxypeptidases: emerging drug targets in biomedicine.

    Joan L. Arolas;Josep Vendrell;Francesc X. Aviles;Lloyd D. Fricker

  • Cloning and Expression of Human Carboxypeptidase Z, a Novel Metallocarboxypeptidase *

    Lixin Song;Lloyd D. Fricker

  • Quantitation of Neuropeptides in Cpefat/Cpefat Mice Using Differential Isotopic Tags and Mass Spectrometry

    Fa yun Che;Lloyd D. Fricker

  • Purification and Characterization of a Membrane‐Bound Enkephalin‐Forming Carboxypeptidase, “Enkephalin Convertase”

    Surachai Supattapone;Lloyd D. Fricker;Solomon H. Snyder

Frequent Co-Authors

Lakshmi A. Devi
Lakshmi A. Devi Icahn School of Medicine at Mount Sinai
Francesc X. Avilés
Francesc X. Avilés Autonomous University of Barcelona
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Donald F. Steiner
Donald F. Steiner University of Chicago
John E. Pintar
John E. Pintar Rutgers, The State University of New Jersey
Yong-Keun Jung
Yong-Keun Jung Seoul National University
Robert Day
Robert Day Université de Sherbrooke
William C. Wetsel
William C. Wetsel Duke University
Miquel Coll
Miquel Coll Spanish National Research Council
Ramona M. Rodriguiz
Ramona M. Rodriguiz Duke University

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