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Neuroscience

D-Index
69
Citations
14310
World Ranking
2677
National Ranking
1257

Overview

John E. Pintar is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily focuses on neuroscience, biochemistry, genetics and molecular biology, and medicine. Within these broad areas, their work concentrates on subfields such as cellular and molecular neuroscience, molecular biology, pharmacology, organic chemistry, and physiology.

Their main topics of study encompass neuropeptides and animal physiology, receptor mechanisms and signaling, alkaloids synthesis and pharmacology, chemical synthesis and alkaloids, pain mechanisms and treatments, pharmacological receptor mechanisms and effects, and the traditional and medicinal uses of Annonaceae.

John E. Pintar has published extensively in multiple venues. Frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), Journal of Medicinal Chemistry, Nature Communications, Diabetologia, and Science.

  • Oxidative Metabolism as a Modulator of Kratom's Biological Actions (2021, Journal of Medicinal Chemistry)
  • Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy (2021, Nature Communications)
  • Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template (2020, Journal of Medicinal Chemistry)
  • Regulation of Opioid Receptors by Their Endogenous Opioid Peptides (2021, Cellular and Molecular Neurobiology)
  • Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine (2021, Neuropsychopharmacology)

Frequent collaborators include Susruta Majumdar, Michael Ansonoff, Amanda Hunkele, Andrew C. Kruegel, and Dalibor Sameš.

Best Publications

  • Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons

    Pat Levitt;John E. Pintar;Xandra O. Breakefield

  • Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice

    Yanxin Zhu;Michael A. King;Alwin G.P. Schuller;Joshua F. Nitsche

  • A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia

    Ivone Gomes;Achla Gupta;Julija Filipovska;Hazel H. Szeto

  • Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1.

    Alwin G.P. Schuller;Michael A. King;Jiwen Zhang;Elizabeth Bolan

  • Targeted Deletion of the Vgf Gene Indicates that the Encoded Secretory Peptide Precursor Plays a Novel Role in the Regulation of Energy Balance

    Seung Hahm;Tooru M. Mizuno;T.John Wu;Jonathan P. Wisor

  • Epidermal stem cells are retained in vivo throughout skin aging.

    Adam Giangreco;Mei Qin;John E Pintar;Fiona M Watt

  • Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.

    Yanxin Zhu;Ming-Sing Hsu;John E. Pintar

  • Prior Activation of Kappa Opioid Receptors by U50,488 Mimics Repeated Forced Swim Stress to Potentiate Cocaine Place Preference Conditioning

    Jay P McLaughlin;Benjamin B Land;Shuang Li;John E Pintar

  • Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5.

    Yun Ning;Alwin G. P. Schuller;Sheri Bradshaw;Peter Rotwein

  • IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth

    Chatarina Lofqvist;Jing Chen;Kip M. Connor;Alexandra C. H. Smith

  • Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

    Alane Gray;Albert W. Tam;Thomas J. Dull;Joel Hayflick

  • The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

    Jeffrey M. Witkin;Michael A. Statnick;Linda M. Rorick-Kehn;John E. Pintar

  • Selective Reward Deficit in Mice Lacking β-Endorphin and Enkephalin

    Michael D. Hayward;John E. Pintar;Malcolm J. Low;Malcolm J. Low

  • Genetic Dissociation of Opiate Tolerance and Physical Dependence in δ-Opioid Receptor-1 and Preproenkephalin Knock-Out Mice

    Joshua F. Nitsche;Alwin G. P. Schuller;Michael A. King;Min Zengh

  • Endogenous κ-Opioid Receptor Systems Regulate Mesoaccumbal Dopamine Dynamics and Vulnerability to Cocaine

    Vladimir I. Chefer;Traci Czyzyk;Elizabeth A. Bolan;Jose Moron

  • Neuropathic pain activates the endogenous κ opioid system in mouse spinal cord and induces opioid receptor tolerance

    Mei Xu;Michael Petraschka;Jay P. McLaughlin;Ruth E. Westenbroek

  • Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

    Susruta Majumdar;Steven Grinnell;Valerie Le Rouzic;Maxim Burgman

  • Female preproenkephalin-knockout mice display altered emotional responses

    A. Ragnauth;A. Schuller;M. Morgan;J. Chan

  • Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse.

    Traci A. Czyzyk;Yun Ning;Ming Sing Hsu;Bonnie Peng

  • Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors

    M.-Y. Jung;B.V. Skryabin;M. Arai;S. Abbondanzo

  • The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor

    Benjamin Adam Samuels;Katherine M Nautiyal;Andrew C Kruegel;Marjorie R Levinstein

Frequent Co-Authors

Gavril W. Pasternak
Gavril W. Pasternak Memorial Sloan Kettering Cancer Center
Ellen M. Unterwald
Ellen M. Unterwald Temple University
Ian Kitchen
Ian Kitchen University of Surrey
Charles Chavkin
Charles Chavkin University of Washington
Grace C. Rossi
Grace C. Rossi Long Island University
Stephen R.J. Salton
Stephen R.J. Salton Icahn School of Medicine at Mount Sinai
Geert M.J. Ramakers
Geert M.J. Ramakers Utrecht University
Ramona M. Rodriguiz
Ramona M. Rodriguiz Duke University
Thomas J. Rogers
Thomas J. Rogers Temple University
William C. Wetsel
William C. Wetsel Duke University

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