World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
85
Citations
25373
World Ranking
1339
National Ranking
675

Biology and Biochemistry

D-Index
85
Citations
25340
World Ranking
3158
National Ranking
1594

Research.com Recognitions

  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles Chavkin is affiliated with the University of Washington in the United States. Their research primarily focuses on Neuroscience and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields including Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology, Physiology, and Behavioral Neuroscience.

The scientist's work explores key topics such as Neuropeptides and Animal Physiology, Receptor Mechanisms and Signaling, Neurotransmitter Receptor Influence on Behavior, Pharmacological Receptor Mechanisms and Effects, Neuroendocrine Regulation and Behavior, Stress Responses and Cortisol, and Adipose Tissue and Metabolism.

Frequent publication venues for Charles Chavkin include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Neuropsychopharmacology
  • Addiction Neuroscience
  • Molecular Psychiatry

Recent papers authored or co-authored by Chavkin include:

  • Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition (2021, Neuropsychopharmacology)
  • Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress (2020, Molecular Psychiatry)
  • Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action (2020, Molecular Pharmacology)
  • Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors (2021, Neuropsychopharmacology)
  • Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward (2022, Addiction Neuroscience)

Their collaborative network includes several frequent co-authors such as Benjamin B. Land, Carlie Neiswanger, Antony D. Abraham, Selena S. Schattauer, and Kandace Kimball.

Charles Chavkin was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2006.

Best Publications

  • Dynorphin is a specific endogenous ligand of the kappa opioid receptor.

    Charles Chavkin;Iain F. James;Avram Goldstein

  • Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

    John T. Williams;Susan L. Ingram;Graeme Henderson;Charles Chavkin

  • Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

    Victor M. Navarro;Michelle L. Gottsch;Charles Chavkin;Hiroaki Okamura

  • Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

    Soren Impey;Melanie Mark;Enrique C Villacres;Steve Poser

  • The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System

    Benjamin B. Land;Michael R. Bruchas;Julia C. Lemos;Mei Xu

  • Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

    Charles Chavkin;Avram Goldstein

  • Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

    Scott T Wong;Jaime Athos;Xavier A Figueroa;Victor V Pineda

  • The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

    M.R. Bruchas;B.B. Land;C. Chavkin

  • κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses

    Jay P. McLaughlin;Monica Marton-Popovici;Charles Chavkin

  • Atrial G protein-activated K+ channel: expression cloning and molecular properties.

    N Dascal;W Schreibmayer;N F Lim;W Wang

  • Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)

    Kelly M. Crowder;Jane M. Gunther;Theresa A. Jones;Brian D. Hale

  • ALTERED BEHAVIOR AND LONG-TERM POTENTIATION IN TYPE I ADENYLYL CYCLASE MUTANT MICE

    Zhi Liang Wu;Steven A. Thomas;Enrique C. Villacres;Zhengui Xia

  • Conducting states of a mammalian serotonin transporter

    Sela Mager;Churl Min;Douglas J. Henry;Charles Chavkin;Charles Chavkin

  • Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive

    Julia C. Lemos;Matthew J. Wanat;Jeffrey S. Smith;Beverly A. S. Reyes

  • Kinase cascades and ligand-directed signaling at the kappa opioid receptor.

    Michael R. Bruchas;Charles Chavkin

  • Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization.

    Wenzhen Jin;Sean Brown;John P. Roche;Candace Hsieh

  • Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

    Benjamin B. Land;Michael R. Bruchas;Selena Schattauer;William J. Giardino

  • Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria

    Michael R. Bruchas;Benjamin B. Land;Megumi Aita;Mei Xu

  • Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus

    John J. Wagner;Gregory W. Terman;Charles Chavkin

  • Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction

    Michael R. Bruchas;Abigail G. Schindler;Haripriya Shankar;Daniel I. Messinger

Frequent Co-Authors

Michael R. Bruchas
Michael R. Bruchas University of Washington
John F. Neumaier
John F. Neumaier University of Washington
Paul E. M. Phillips
Paul E. M. Phillips University of Washington
Robert M. Caudle
Robert M. Caudle University of Florida
Teresa A. Milner
Teresa A. Milner Cornell University
Brigitte L. Kieffer
Brigitte L. Kieffer University of Strasbourg
Floyd E. Bloom
Floyd E. Bloom Scripps Research Institute
Christopher J. Evans
Christopher J. Evans University of California, Los Angeles
Henry A. Lester
Henry A. Lester California Institute of Technology
John E. Pintar
John E. Pintar Rutgers, The State University of New Jersey

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Related Online Degrees & Career Pathways

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Additionally, options for online clinical mental health counseling can complement neuroscience studies—preparing graduates for impactful roles in hospitals, schools, or private practice.

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