World's Best Scientists 2026 revealed!

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Medicine

D-Index
105
Citations
40393
World Ranking
6778
National Ranking
3578

Overview

Mary Jeanne Kreek was affiliated with Rockefeller University in the United States. Their research primarily focused on neuroscience and medicine, with significant contributions in subfields such as cellular and molecular neuroscience, molecular biology, pharmacology, epidemiology, and public health.

The scientist's body of work encompassed a range of topics, including:

  • Neuropeptides and Animal Physiology
  • Neurotransmitter Receptor Influence on Behavior
  • Receptor Mechanisms and Signaling
  • Substance Abuse Treatment and Outcomes
  • Opioid Use Disorder Treatment
  • Cannabis and Cannabinoid Research
  • Pain Mechanisms and Treatments

Mary Jeanne Kreek published extensively in multiple venues. The most frequent publication outlets were:

  • Psychopharmacology
  • Neuropharmacology
  • Pharmacology Biochemistry and Behavior
  • Handbook of experimental pharmacology
  • Synapse

Frequent coauthors included:

  • Eduardo R. Butelman (15 joint publications)
  • Matthew Randesi (9 joint publications)
  • Brian Reed (8 joint publications)
  • Yan Zhou (8 joint publications)
  • Orna Levran (7 joint publications)

The scientist contributed to several papers in research on opioid addiction and receptor pharmacology, such as:

  • Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond, 2022, Scientific Reports
  • Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat, 2020, Psychopharmacology
  • Review of addiction risk potential associated with adolescent opioid use, 2020, Pharmacology Biochemistry and Behavior
  • Kappa Opioid Receptor Antagonists as Potential Therapeutics for Mood and Substance Use Disorders, 2020, Handbook of experimental pharmacology
  • Preclinical Studies on Nalfurafine (TRK-820), a Clinically Used KOR Agonist, 2021, Handbook of experimental pharmacology

Their research integrated molecular and cellular approaches to better understand receptor signaling mechanisms and their implications for substance use disorders and pain treatment. The work often explored neuropeptides and receptor influences on behavior, highlighting the role of opioid receptors.

Best Publications

  • Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

    Mary Jeanne Kreek;David A Nielsen;Eduardo R Butelman;K Steven LaForge

  • Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity : possible implications for opiate addiction

    Cherie Bond;K. Steven LaForge;Mingting Tian;Dorothy Melia

  • Stress, Dysregulation of Drug Reward Pathways, and the Transition to Drug Dependence

    George Koob;Mary Jeanne Kreek

  • Drug dependence: stress and dysregulation of brain reward pathways.

    Mary Jeanne Kreek;George F. Koob

  • Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes

    Rajita Sinha;Miguel Garcia;Prashni Paliwal;Mary Jeanne Kreek

  • HIV-1 Infection Among Intravenous Drug Users in Manhattan, New York City, From 1977 Through 1987

    Don C. Des Jarlais;Samuel R. Friedman;David M. Novick;Jo L. Sotheran

  • 1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial.

    Johan Kakko;Kerstin Dybrandt Svanborg;Mary Jeanne Kreek;Markus Heilig

  • Naltrexone decreases craving and alcohol self- administration in alcohol-dependent subjects and activates the hypothalamo--pituitary--adrenocortical axis.

    Stephanie S O'Malley;Suchitra Krishnan-Sarin;Conor Farren;Rajita Sinha

  • Pharmacotherapy of addictions

    Mary Jeanne Kreek;K. Steven LaForge;Eduardo Butelman

  • Effective medical treatment of opiate addiction

    L. L. Judd;M. G. Marston;C. Attkisson;W. Berrettini

  • Common liability to addiction and “gateway hypothesis”: Theoretical, empirical and evolutionary perspective

    Michael M. Vanyukov;Ralph E. Tarter;Galina P. Kirillova;Levent Kirisci

  • Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments

    Mary Jeanne Kreek;Gavin Bart;Charles Lilly;K. Steven Laforge

  • Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes.

    Rajita Sinha;Helen C. Fox;Kwang-ik Adam Hong;Julie Hansen

  • Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states.

    Rajita Sinha;Makram Talih;Robert Malison;Ned Cooney

  • Treatment of opioid-induced constipation with oral naloxone: a pilot study.

    Joan A Culpepper-Morgan;Joan A Culpepper-Morgan;Joan A Culpepper-Morgan;Charles E Inturrisi;Charles E Inturrisi;Charles E Inturrisi;Russell K Portenoy;Russell K Portenoy;Russell K Portenoy;Kathleen Foley;Kathleen Foley;Kathleen Foley

  • Methadone‐Related Opioid Agonist Pharmacotherapy for Heroin Addiction: History, Recent Molecular and Neurochemical Research and Future in Mainstream Medicine

    Mary Jeanne Kreek

  • Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors.

    Ellen M. Unterwald;Joshua M. Rubenfeld;Mary Jeanne Kreek

  • Medical safety and side effects of methadone in tolerant individuals.

    Mary Jeanne Kreek

  • ‘Binge’ cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen

    Rudolph Spangler;Ellen M. Unterwald;Mary Jeanne Kreek

  • Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden.

    Gavin Bart;Mary Jeanne Kreek;Mary Jeanne Kreek;Jurg Ott;K Steven LaForge

Frequent Co-Authors

Yan Zhou
Yan Zhou Rockefeller University
Jurg Ott
Jurg Ott Rockefeller University
David A. Nielsen
David A. Nielsen Baylor College of Medicine
Ellen M. Unterwald
Ellen M. Unterwald Temple University
Teresa A. Milner
Teresa A. Milner Cornell University
Thomas R. Kosten
Thomas R. Kosten Baylor College of Medicine
Brian T. Chait
Brian T. Chait Rockefeller University
Bruce S. McEwen
Bruce S. McEwen Rockefeller University
Rajita Sinha
Rajita Sinha Yale University
Suzanne M. Leal
Suzanne M. Leal Columbia University Medical Center

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Best Scientists Citing Mary Jeanne Kreek