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Biology and Biochemistry

D-Index
145
Citations
94384
World Ranking
215
National Ranking
149

Overview

Brian T. Chait is affiliated with Rockefeller University in the United States. Their research work spans several main fields, primarily in Biochemistry, Genetics and Molecular Biology, with additional contributions in Medicine.

Their work covers significant subfields including Molecular Biology, Infectious Diseases, Genetics, Immunology, and Ecology. The principal topics studied in their body of research include:

  • RNA Research and Splicing
  • Nuclear Structure and Function
  • RNA and protein synthesis mechanisms
  • SARS-CoV-2 and COVID-19 Research
  • RNA modifications and cancer
  • Bacteriophages and microbial interactions
  • Monoclonal and Polyclonal Antibodies Research

Brian T. Chait has published extensively, with frequent publication venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • EMPIAR dataset
  • eLife
  • Molecular Cell

Among their recent scholarly articles are the following:

  • Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex, 2020, Cell
  • Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis, 2021, Cell
  • Comprehensive structure and functional adaptations of the yeast nuclear pore complex, 2022, Cell
  • Stepwise Promoter Melting by Bacterial RNA Polymerase, 2020, Molecular Cell
  • Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex, 2021, Proceedings of the National Academy of Sciences

Collaboration is a notable aspect of their research. Frequent co-authors include:

  • Paul Dominic B. Olinares
  • Michael P. Rout
  • Seth A. Darst
  • Elizabeth A. Campbell
  • Andrej Šali

Best Publications

  • The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

    Declan A. Doyle;João Morais Cabral;Richard A. Pfuetzner;Anling Kuo

  • Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

    Jeffrey L. Halaas;Ketan S. Gajiwala;Margherita Maffei;Steven L. Cohen

  • Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers.

    Franz Hillenkamp;Michael Karas;Ronald C. Beavis;Brian T. Chait

  • X-ray structure of a voltage-dependent K+ channel

    Youxing Jiang;Alice Lee;Jiayun Chen;Vanessa Ruta

  • X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.

    Raimund Dutzler;Ernest B. Campbell;Martine Cadene;Brian T. Chait

  • Crystal structure and mechanism of a calcium-gated potassium channel

    Youxing Jiang;Alice Lee;Jiayun Chen;Martine Cadene

  • The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism

    Michael P. Rout;John D. Aitchison;Adisetyantari Suprapto;Kelly Hjertaas

  • Accurate quantitation of protein expression and site-specific phosphorylation

    Y. Oda;K. Huang;F. R. Cross;D. Cowburn

  • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.

    Johannes F. Scheid;Hugo Mouquet;Beatrix Ueberheide;Ron Diskin

  • The molecular architecture of the nuclear pore complex

    Frank Alber;Svetlana Dokudovskaya;Liesbeth M. Veenhoff;Wenzhu Zhang

  • Proteomic analysis of the mammalian nuclear pore complex

    Janet M. Cronshaw;Andrew N. Krutchinsky;Wenzhu Zhang;Brian T. Chait

  • Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.

    Yun Zhong;Qing Jun Wang;Qing Jun Wang;Xianting Li;Ying Yan

  • Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome.

    Yoshiya Oda;Takeshi Nagasu;Brian T. Chait

  • Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

    Alan H. Fairlamb;Peter Blackburn;Peter Ulrich;Brian T. Chait

  • ProFound: An Expert System for Protein Identification Using Mass Spectrometric Peptide Mapping Information

    Wenzhu Zhang;Brian T. Chait

  • Probing conformational changes in proteins by mass spectrometry

    Swapan K. Chowdhury;Viswanatham Katta;Brian T. Chait

  • Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF

    Yali Dou;Thomas A. Milne;Thomas A. Milne;Alan J. Tackett;Edwin R. Smith

  • ABI5 acts downstream of ABI3 to execute an ABA-dependent growth arrest during germination.

    Luis Lopez-Molina;Sébastien Mongrand;Derek T. McLachlin;Brian T. Chait

  • Influence of Matrix Solution Conditions on the MALDI-MS Analysis of Peptides and Proteins

    Steven L. Cohen;Brian T. Chait

  • Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

    Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent

Frequent Co-Authors

Michael P. Rout
Michael P. Rout Rockefeller University
David Fenyö
David Fenyö New York University
Andrej Sali
Andrej Sali University of California, San Francisco
Rong Wang
Rong Wang Icahn School of Medicine at Mount Sinai
James M. Manning
James M. Manning Northeastern University
John D. Aitchison
John D. Aitchison University of Minnesota
Stephen B. H. Kent
Stephen B. H. Kent University of Chicago
Seth A. Darst
Seth A. Darst Rockefeller University
Ileana M. Cristea
Ileana M. Cristea Princeton University
Roderick MacKinnon
Roderick MacKinnon Howard Hughes Medical Institute

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