Roderick MacKinnon

Research.com Recognitions

• 2007 - Royal Netherlands Academy of Arts and Sciences
• 2003 - Louisa Gross Horwitz Prize, Columbia University
• 2003 - Nobel Prize for discoveries concerning channels in cell membranes; for structural and mechanistic studies of ion channels
• 2001 - Canada Gairdner International Award
• 2001 - Perl-UNC Prize, University of North Carolina at Chapel Hill Solving the Crystal Structure of the Potassium Channel.
• 2000 - Member of the National Academy of Sciences
• 1999 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
• 1998 - W. Alden Spencer Award, College of Physicians and Surgeons

Overview

Best Publications

• The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

  Declan A. Doyle;João Morais Cabral;Richard A. Pfuetzner;Anling Kuo

  8512
  Citations

• Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel

  Stephen B. Long;Ernest B. Campbell;Roderick MacKinnon

  3256
  Citations

• Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.

  Yufeng Zhou;João H. Morais-Cabral;João H. Morais-Cabral;Amelia Kaufman;Roderick MacKinnon

  2536
  Citations

• X-ray structure of a voltage-dependent K+ channel

  Youxing Jiang;Alice Lee;Jiayun Chen;Vanessa Ruta

  2345
  Citations

• Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.

  Stephen B. Long;Xiao Tao;Ernest B. Campbell;Roderick MacKinnon

  2129
  Citations

• X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.

  Raimund Dutzler;Ernest B. Campbell;Martine Cadene;Brian T. Chait

  1966
  Citations

• Crystal structure and mechanism of a calcium-gated potassium channel

  Youxing Jiang;Alice Lee;Jiayun Chen;Martine Cadene

  1692
  Citations

• Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.

  Declan A. Doyle;Alice Lee;John Lewis;Eunjoon Kim

  1476
  Citations

• The open pore conformation of potassium channels.

  Youxing Jiang;Alice Lee;Jiayun Chen;Martine Cadene

  1466
  Citations

• Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling

  Stephen B. Long;Ernest B. Campbell;Roderick MacKinnon

  1407
  Citations

• Determination of the subunit stoichiometry of a voltage-activated potassium channel.

  Roderick MacKinnon

  1309
  Citations

• Principles of selective ion transport in channels and pumps.

  Eric Gouaux;Roderick MacKinnon

  1294
  Citations

• Mutations in the K+ channel signature sequence

  L. Heginbotham;Zhe Lu;T. Abramson;R. Mackinnon

  1181
  Citations

• The principle of gating charge movement in a voltage-dependent K + channel

  Youxing Jiang;Vanessa Ruta;Jiayun Chen;Alice Lee

  1094
  Citations

• Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

  J. K. Gwathmey;L. Copelas;R. MacKinnon;F. J. Schoen

  1082
  Citations

• Energetic optimization of ion conduction rate by the K+ selectivity filter.

  João H. Morais-Cabral;Yufeng Zhou;Roderick MacKinnon

  1042
  Citations

• Contribution of the S4 segment to gating charge in the Shaker K+ channel.

  Sanjay Kumar Aggarwal;Roderick MacKinnon

  1024
  Citations

• Gating the Selectivity Filter in ClC Chloride Channels

  Raimund Dutzler;Ernest B. Campbell;Roderick MacKinnon

  983
  Citations

• Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels.

  Roderick MacKinnon;Gary Yellen

  797
  Citations

• Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors

  Ming Zhou;João H. Morais-Cabral;João H. Morais-Cabral;Sabine Mann;Roderick MacKinnon

  688
  Citations

• A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K^+ Channels

  Lise Heginbotham;Tatiana Abramson;Roderick MacKinnon

  679
  Citations