Michael C. Sanguinetti

Overview

Best Publications

• A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

  Michael C Sanguinetti;Changan Jiang;Mark E Curran;Mark T Keating

  2833
  Citations

• Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

  Michael C. Sanguinetti;Nancy K. Jurkiewicz

  2194
  Citations

• Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.

  Sanguinetti Mc;Curran Me;Zou A;Shen J

  2097
  Citations

• Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.

  Igor Splawski;Katherine W. Timothy;Leah M. Sharpe;Niels Decher

  1858
  Citations

• hERG potassium channels and cardiac arrhythmia

  Michael C. Sanguinetti;Martin Tristani-Firouzi

  1777
  Citations

• Molecular and cellular mechanisms of cardiac arrhythmias.

  Mark T. Keating;Michael C. Sanguinetti

  1233
  Citations

• International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels

  Aguan D. Wei;George A. Gutman;Richard W Aldrich;K. George Chandy

  1179
  Citations

• Loss-of-Function Mutations in the Cardiac Calcium Channel Underlie a New Clinical Entity Characterized by ST-Segment Elevation, Short QT Intervals, and Sudden Cardiac Death

  Charles Antzelevitch;Guido D. Pollevick;Jonathan M. Cordeiro;Oscar Casis

  1143
  Citations

• A structural basis for drug-induced long QT syndrome

  John S. Mitcheson;Jun Chen;Monica Lin;Chris Culberson

  1095
  Citations

• Mutations in the hminK gene cause long QT syndrome and suppress IKs function.

  Igor Splawski;Martin Tristani-Firouzi;Michael H. Lehmann;Michael C. Sanguinetti

  971
  Citations

• Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

  Igor Splawski;Katherine W. Timothy;Katherine W. Timothy;Niels Decher;Pradeep Kumar

  725
  Citations

• Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide.

  Nancy K. Jurkiewicz;Michael C. Sanguinetti

  725
  Citations

• Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

  M C Sanguinetti;R S Kass

  667
  Citations

• International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels

  George A. Gutman;K. George Chandy;John P. Adelman;Jayashree Aiyar

  598
  Citations

• Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

  Michael C. Sanguinetti;Mark E. Curran;Peter S. Spector;Mark T. Keating

  562
  Citations

• Fast inactivation causes rectification of the IKr channel.

  Peter S. Spector;Mark E. Curran;Anruo Zou;Mark T. Keating

  503
  Citations

• Compound mutations: a common cause of severe long-QT syndrome.

  Peter Westenskow;Igor Splawski;Katherine W. Timothy;Mark T. Keating

  429
  Citations

• Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium.

  Steve J. Compton;Robert L. Lux;Matthew R. Ramsey;Katie R. Strelich

  413
  Citations

• Drug-induced torsades de pointes and implications for drug development.

  Robert R. Fenichel;Marek Malik;Charles Antzelevitch;Michael Sanguinetti

  409
  Citations

• Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

  Michael C. Sanguinetti;John S. Mitcheson

  406
  Citations