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Biology and Biochemistry

D-Index
58
Citations
18222
World Ranking
12946
National Ranking
5514

Research.com Recognitions

  • 2019 - Member of the National Academy of Sciences

Overview

Jue Chen is affiliated with Rockefeller University in the United States. Their research spans multiple fields with a primary focus on medicine and biochemistry, genetics, and molecular biology. The subfields they have contributed to include surgery, cardiology and cardiovascular medicine, molecular biology, pulmonary and respiratory medicine, and radiology, nuclear medicine and imaging.

Their work covers a range of topics, including:

  • Coronary Interventions and Diagnostics
  • Acute Myocardial Infarction Research
  • Drug Transport and Resistance Mechanisms
  • Cystic Fibrosis Research Advances
  • RNA Interference and Gene Delivery
  • Cardiac Imaging and Diagnostics
  • Lipoproteins and Cardiovascular Health

Jue Chen has frequently published in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • EMPIAR dataset
  • Proceedings of the National Academy of Sciences
  • Catheterization and Cardiovascular Interventions
  • PubMed

Notable recent papers include:

  • "Mechanism of CFTR correction by type I folding correctors," 2022, Cell
  • "Molecular structures reveal synergistic rescue of Δ508 CFTR by Trikafta modulators," 2022, Science
  • "Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses," 2020, eLife
  • "CFTR function, pathology and pharmacology at single-molecule resolution," 2023, Nature
  • "Molecular structures of the eukaryotic retinal importer ABCA4," 2021, eLife

Jue Chen has collaborated extensively with several researchers, including:

  • Shubin Qiao
  • Jinqing Yuan
  • V Manon
  • James Lee
  • Yuejin Yang

The scientist is a member of the National Academy of Sciences, an award received in 2019.

Best Publications

  • Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

    Amy L. Davidson;Elie Dassa;Cedric Orelle;Jue Chen

  • ATP-binding cassette transporters in bacteria.

    Amy L Davidson;Jue Chen

  • Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation

    I-Mei Yu;Wei Zhang;Heather A. Holdaway;Long Li

  • Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation.

    Jue Chen;Kon Ho Lee;David A Steinhauer;David J Stevens

  • The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation

    Long Li;Shee-Mei Lok;I-Mei Yu;Ying Zhang

  • A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle.

    Jue Chen;Gang Lu;Jeffrey Lin;Amy L Davidson

  • Crystal structure of a catalytic intermediate of the maltose transporter

    Michael L. Oldham;Dheeraj Khare;Florante A. Quiocho;Amy L. Davidson

  • Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

    Mi Sun Jin;Michael L. Oldham;Qiuju Zhang;Jue Chen;Jue Chen

  • Molecular Structure of the Human CFTR Ion Channel

    Fangyu Liu;Zhe Zhang;László Csanády;David C. Gadsby

  • Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation.

    Youngjin Kim;Jue Chen

  • Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.

    Zachary Lee Johnson;Jue Chen

  • N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA2 subunit to form an N cap that terminates the triple-stranded coiled coil

    Jue Chen;John J. Skehel;Don C. Wiley

  • Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator

    Zhe Zhang;Jue Chen

  • Structural insights into ABC transporter mechanism

    Michael L Oldham;Amy L Davidson;Jue Chen

  • Alternating access in maltose transporter mediated by rigid-body rotations.

    Dheeraj Khare;Michael L. Oldham;Cedric Orelle;Amy L. Davidson

  • Conformational Changes of CFTR upon Phosphorylation and ATP Binding

    Zhe Zhang;Fangyu Liu;Jue Chen;Jue Chen

  • Trapping the transition state of an ATP-binding cassette transporter: Evidence for a concerted mechanism of maltose transport

    Jue Chen;Susan Sharma;Florante A. Quiocho;Amy L. Davidson

  • Crystal Structure of the Maltose Transporter in a Pretranslocation Intermediate State

    Michael L. Oldham;Jue Chen

  • Snapshots of the maltose transporter during ATP hydrolysis.

    Michael L. Oldham;Jue Chen

  • Molecular structure of the ATP-bound, phosphorylated human CFTR.

    Zhe Zhang;Fangyu Liu;Jue Chen

Frequent Co-Authors

Don C. Wiley
Don C. Wiley Harvard University
John J. Skehel
John J. Skehel The Francis Crick Institute
Michael G. Rossmann
Michael G. Rossmann Purdue University West Lafayette
Richard Kuhn
Richard Kuhn Purdue University West Lafayette
Nikolaus Grigorieff
Nikolaus Grigorieff Howard Hughes Medical Institute
Florante A. Quiocho
Florante A. Quiocho Baylor College of Medicine
Jon M. Huibregtse
Jon M. Huibregtse The University of Texas at Austin
Paul R. Chipman
Paul R. Chipman University of Florida
Brian T. Chait
Brian T. Chait Rockefeller University
Roderick MacKinnon
Roderick MacKinnon Howard Hughes Medical Institute

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