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Jon M. Huibregtse

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
27430
World Ranking
11094
National Ranking
4798

Jon M. Huibregtse publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Jon M. Huibregtse sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 94 publications — 4th percentile

4% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Jon M. Huibregtse D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Jon M. Huibregtse sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 61 D-Index — 44th percentile

44% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Jon M. Huibregtse is affiliated with The University of Texas at Austin in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a substantial focus on molecular and cell biology subfields.

The main fields of study for Huibregtse include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of study explored in their work cover:

  • Molecular Biology
  • Cell Biology
  • Immunology
  • Infectious Diseases
  • Oncology

Primary topics in their research involve:

  • Cellular transport and secretion
  • Ubiquitin and proteasome pathways
  • Interferon and immune responses
  • Endoplasmic Reticulum Stress and Disease
  • Lipid Membrane Structure and Behavior
  • Cell Adhesion Molecules Research
  • SARS-CoV-2 and COVID-19 Research

Frequent co-authors collaborating with Huibregtse include:

  • Jeanne C. Stachowiak
  • Susovan Sarkar
  • Feng Yuan
  • Grant Ashby
  • Jessica Perez

The scientist's recent publications demonstrate involvement in studies on viral replication, protein degradation, and proteostasis. Key papers include:

  • "Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins," 2020, Cell Reports
  • "Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells," 2020, PLoS Biology
  • "6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro," 2021, iScience
  • "A masked initiation region in retinoblastoma protein regulates its proteasomal degradation," 2020, Nature Communications
  • "6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Huibregtse's work is regularly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Cell Reports
  • iScience
  • Nature Communications

Best Publications

  • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

    Martin Scheffner;Bruce A. Werness;Jon M. Huibregtse;Arnold J. Levine

  • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

    Martin Scheffner;Jon M. Huibregtse;Richard D. Vierstra;Peter M. Howley

  • A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

  • Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

    Martin Scheffner;Ulrike Nuber;Jon M. Huibregtse

  • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • In Vivo Ubiquitination and Proteasome-mediated Degradation of p53

    Carl G. Maki;Jon M. Huibregtse;Peter M. Howley

  • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

    Lan Huang;Elspeth Kinnucan;Guangli Wang;Sylvie Beaudenon

  • Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase

    Shunsuke Nakagawa;Jon M. Huibregtse

  • Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency

    Dusan Bogunovic;Minji Byun;Larissa A. Durfee;Avinash Abhyankar

  • A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.

    Ronald N. Harty;Melissa E. Brown;Guangli Wang;Jon M Huibregtse

  • Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

    Chen Zhao;Carilee Denison;Jon M. Huibregtse;Steven Gygi

  • Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

    J.A. Mietz;T. Unger;J.M. Huibregtse;P.M. Howley

  • INTERACTIONS OF HPV E6 AND E7 ONCOPROTEINS WITH TUMOUR SUPPRESSOR GENE PRODUCTS

    K. Munger;M. Scheffner;J. M. Huibregtse;P. M. Howley

  • The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

    Larissa A. Durfee;Nancy Lyon;Kyungwoon Seo;Jon M. Huibregtse

  • The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein

    Chen Zhao;Sylvie L. Beaudenon;Melissa L. Kelley;M. Brett Waddell

  • Herc5, an Interferon-induced HECT E3 Enzyme, Is Required for Conjugation of ISG15 in Human Cells

    Anahita Dastur;Sylvie Beaudenon;Melissa Kelley;Robert M. Krug

  • Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

    Martin Scheffner;Jon M. Huibregtse;Peter M. Howley

  • Correction: A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

Frequent Co-Authors

Peter M. Howley
Peter M. Howley Harvard Medical School
Martin Scheffner
Martin Scheffner University of Konstanz
Karl Münger
Karl Münger Tufts University
Robert M. Krug
Robert M. Krug The University of Texas at Austin
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Tanya T. Paull
Tanya T. Paull The University of Texas at Austin
Jue Chen
Jue Chen Rockefeller University
Donald P. McDonnell
Donald P. McDonnell Duke University
Andreas T Matouschek
Andreas T Matouschek The University of Texas at Austin
Saleh Al-Muhsen
Saleh Al-Muhsen King Saud University

External Links

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Online study in these areas allows for career progression and supports a wide range of interests within biology, health, and biochemistry.

Best Scientists Citing Jon M. Huibregtse

Lawrence Banks

Lawrence Banks

International Centre for Genetic Engineering and Biotechnology

Publications: 98

Jean-Laurent Casanova

Jean-Laurent Casanova

The University of Texas Southwestern Medical Center

Publications: 74

Laurent Abel

Laurent Abel

Université Paris Cité

Publications: 74

Aaron Ciechanover

Aaron Ciechanover

Technion – Israel Institute of Technology

Publications: 66

Karl Münger

Karl Münger

Tufts University

Publications: 62

Martin Scheffner

Martin Scheffner

University of Konstanz

Publications: 59

Stéphanie Boisson-Dupuis

Stéphanie Boisson-Dupuis

Université Paris Cité

Publications: 54

Peter M. Howley

Peter M. Howley

Harvard Medical School

Publications: 53

Jacinta Bustamante

Jacinta Bustamante

Rockefeller University

Publications: 44

Shigetsugu Hatakeyama

Shigetsugu Hatakeyama

Hokkaido University

Publications: 43

Laimonis A. Laimins

Laimonis A. Laimins

Northwestern University

Publications: 39

Paul F. Lambert

Paul F. Lambert

University of Wisconsin–Madison

Publications: 38

Brenda A. Schulman

Brenda A. Schulman

Max Planck Society

Publications: 34

Dong-Er Zhang

Dong-Er Zhang

University of California, San Diego

Publications: 34

David P. Lane

David P. Lane

Karolinska Institute

Publications: 31

Denise A. Galloway

Denise A. Galloway

Fred Hutchinson Cancer Research Center

Publications: 31

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