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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
27430
World Ranking
11094
National Ranking
4798

Overview

Jon M. Huibregtse is affiliated with The University of Texas at Austin in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a substantial focus on molecular and cell biology subfields.

The main fields of study for Huibregtse include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of study explored in their work cover:

  • Molecular Biology
  • Cell Biology
  • Immunology
  • Infectious Diseases
  • Oncology

Primary topics in their research involve:

  • Cellular transport and secretion
  • Ubiquitin and proteasome pathways
  • Interferon and immune responses
  • Endoplasmic Reticulum Stress and Disease
  • Lipid Membrane Structure and Behavior
  • Cell Adhesion Molecules Research
  • SARS-CoV-2 and COVID-19 Research

Frequent co-authors collaborating with Huibregtse include:

  • Jeanne C. Stachowiak
  • Susovan Sarkar
  • Feng Yuan
  • Grant Ashby
  • Jessica Perez

The scientist's recent publications demonstrate involvement in studies on viral replication, protein degradation, and proteostasis. Key papers include:

  • "Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins," 2020, Cell Reports
  • "Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells," 2020, PLoS Biology
  • "6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro," 2021, iScience
  • "A masked initiation region in retinoblastoma protein regulates its proteasomal degradation," 2020, Nature Communications
  • "6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Huibregtse's work is regularly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Cell Reports
  • iScience
  • Nature Communications

Best Publications

  • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

    Martin Scheffner;Bruce A. Werness;Jon M. Huibregtse;Arnold J. Levine

  • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

    Martin Scheffner;Jon M. Huibregtse;Richard D. Vierstra;Peter M. Howley

  • A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

  • Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

    Martin Scheffner;Ulrike Nuber;Jon M. Huibregtse

  • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • In Vivo Ubiquitination and Proteasome-mediated Degradation of p53

    Carl G. Maki;Jon M. Huibregtse;Peter M. Howley

  • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

    Lan Huang;Elspeth Kinnucan;Guangli Wang;Sylvie Beaudenon

  • Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase

    Shunsuke Nakagawa;Jon M. Huibregtse

  • Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency

    Dusan Bogunovic;Minji Byun;Larissa A. Durfee;Avinash Abhyankar

  • A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.

    Ronald N. Harty;Melissa E. Brown;Guangli Wang;Jon M Huibregtse

  • Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

    Chen Zhao;Carilee Denison;Jon M. Huibregtse;Steven Gygi

  • Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

    J.A. Mietz;T. Unger;J.M. Huibregtse;P.M. Howley

  • INTERACTIONS OF HPV E6 AND E7 ONCOPROTEINS WITH TUMOUR SUPPRESSOR GENE PRODUCTS

    K. Munger;M. Scheffner;J. M. Huibregtse;P. M. Howley

  • The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

    Larissa A. Durfee;Nancy Lyon;Kyungwoon Seo;Jon M. Huibregtse

  • The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein

    Chen Zhao;Sylvie L. Beaudenon;Melissa L. Kelley;M. Brett Waddell

  • Herc5, an Interferon-induced HECT E3 Enzyme, Is Required for Conjugation of ISG15 in Human Cells

    Anahita Dastur;Sylvie Beaudenon;Melissa Kelley;Robert M. Krug

  • Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

    Martin Scheffner;Jon M. Huibregtse;Peter M. Howley

  • Correction: A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

Frequent Co-Authors

Peter M. Howley
Peter M. Howley Harvard Medical School
Martin Scheffner
Martin Scheffner University of Konstanz
Karl Münger
Karl Münger Tufts University
Robert M. Krug
Robert M. Krug The University of Texas at Austin
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Tanya T. Paull
Tanya T. Paull The University of Texas at Austin
Jue Chen
Jue Chen Rockefeller University
Donald P. McDonnell
Donald P. McDonnell Duke University
Andreas T Matouschek
Andreas T Matouschek The University of Texas at Austin
Saleh Al-Muhsen
Saleh Al-Muhsen King Saud University

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