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Martin Scheffner

Martin Scheffner

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
29818
World Ranking
8448
National Ranking
618

Overview

Martin Scheffner is a researcher affiliated with the University of Konstanz in Germany. Their academic work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a focus on areas including Molecular Biology, Oncology, Materials Chemistry, Genetics, and Epidemiology.

The research topics extensively covered by Scheffner include:

  • Ubiquitin and proteasome pathways
  • Peptidase inhibition and analysis
  • Protein degradation and inhibitors
  • Cancer-related molecular pathways
  • Epigenetics and DNA methylation
  • Autophagy in disease and therapy
  • Histone deacetylase inhibitors research

Recent publications by Scheffner demonstrate active engagement in molecular mechanisms related to ubiquitin and protein regulation. Notable works include:

  • "Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere," 2021, EMBO Reports
  • "Site-specific ubiquitylation acts as a regulator of linker histone H1," 2021, Nature Communications
  • "The Length of a Ubiquitin Chain: A General Factor for Selective Recognition by Ubiquitin-Binding Proteins," 2020, Angewandte Chemie International Edition
  • "Chemoproteomic discovery of a human RNA ligase," 2023, Nature Communications
  • "Structural and functional consequences of NEDD8 phosphorylation," 2021, Nature Communications

Scheffner frequently publishes in the following journals and venues:

  • Nature Communications
  • ChemBioChem
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Chemical Theory and Computation
  • Small Structures

Throughout their career, Scheffner has collaborated regularly with several researchers, including:

  • Andreas Marx (19 joint publications)
  • Florian Stengel (16 joint publications)
  • Eva Höllmüller (8 joint publications)
  • Simon Maria Kienle (7 joint publications)
  • Katrin Stuber (6 joint publications)

Best Publications

  • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

    Martin Scheffner;Bruce A. Werness;Jon M. Huibregtse;Arnold J. Levine

  • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

    Martin Scheffner;Jon M. Huibregtse;Richard D. Vierstra;Peter M. Howley

  • A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

  • Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

    Martin Scheffner;Ulrike Nuber;Jon M. Huibregtse

  • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

    Martin Scheffner;Karl Münger;Janet C. Byrne;Peter M. Howley

  • Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

    Yasuyuki Fujita;Gerd Krause;Martin Scheffner;Dietmar Zechner

  • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1

    Monica Gostissa;Arnd Hengstermann;Valentina Fogal;Peter Sandy

  • The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.

    Sovana Adhikary;Federica Marinoni;Andreas Hock;Esther Hulleman

  • Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells

    Thomas Rothmann;Arnd Hengstermann;Noel J. Whitaker;Martin Scheffner

  • HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

    Laëtitia K. Linares;Arnd Hengstermann;Aaron Ciechanover;Stefan Müller

  • siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells.

    Karin Butz;Tutik Ristriani;Arnd Hengstermann;Claudia Denk

  • INTERACTIONS OF HPV E6 AND E7 ONCOPROTEINS WITH TUMOUR SUPPRESSOR GENE PRODUCTS

    K. Munger;M. Scheffner;J. M. Huibregtse;P. M. Howley

  • Interaction between ubiquitin–protein ligase SCF SKP2 and E2F-1 underlies the regulation of E2F-1 degradation

    Alain Marti;Christopher Wirbelauer;Martin Scheffner;Wilhelm Krek

  • RNA helicase activity associated with the human p68 protein

    Harald Hirling;Martin Scheffner;Tobias Restle;Hans Stahl

  • Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

    Martin Scheffner;Jon M. Huibregtse;Peter M. Howley

  • Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects.

    Martin Scheffner;Sharad Kumar;Sharad Kumar;Sharad Kumar

  • Correction: A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

Frequent Co-Authors

Andreas Marx
Andreas Marx University of Konstanz
Peter M. Howley
Peter M. Howley Harvard Medical School
Jon M. Huibregtse
Jon M. Huibregtse The University of Texas at Austin
Karl Münger
Karl Münger Tufts University
Aaron Ciechanover
Aaron Ciechanover Technion – Israel Institute of Technology
Helmut Cölfen
Helmut Cölfen University of Konstanz
Thomas Sommer
Thomas Sommer Max Delbrück Center for Molecular Medicine
Sharad Kumar
Sharad Kumar University of Adelaide
Markus Drechsler
Markus Drechsler University of Bayreuth
Yong-hui Jiang
Yong-hui Jiang Yale School of Medicine

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