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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Molecular Biology

D-Index
123
Citations
69395
World Ranking
235
National Ranking
142

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2002 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1996 - Fellow of the American Academy of Arts and Sciences
  • 1994 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 1994 - Member of the National Academy of Medicine (NAM)
  • 1993 - Member of the National Academy of Sciences

Overview

Peter M. Howley is affiliated with Harvard Medical School in the United States. Their research primarily focuses on molecular biology, genetics, immunology, and the intersection of these fields with cancer research.

The scientist has contributed to fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Their subfields of study include Oncology, Immunology, Genetics, and Cancer Research, reflecting an interdisciplinary approach to disease mechanisms and immune responses.

Key topics in their work cover:

  • Cancer-related Molecular Pathways
  • Interferon and immune responses
  • Virus-based gene therapy research
  • MicroRNA in disease regulation

Recent papers demonstrate engagement with the study of molecular mechanisms in virus-associated cancers. Publications include:

  • "Live cell, image-based high-throughput screen to quantitate p53 stabilization and viability in human papillomavirus positive cancer cells," 2021, Virology
  • "Identification of microRNAs that stabilize p53 in HPV-positive cancer cells," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in research efforts are Gustavo Martínez-Noël, Patricia Szajner, Rebecca E. Kramer, Kathleen A. Boyland, and Jennifer A. Smith, indicating sustained partnerships across multiple studies.

Publication venues have included Virology and bioRxiv, highlighting contributions to virology and preprint open-access research platforms.

Peter M. Howley has received several recognitions:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2002
  • Fellow of the American Academy of Arts and Sciences, 1996
  • Paul Ehrlich and Ludwig Darmstaedter Prize, 1994
  • Member of the National Academy of Medicine (NAM), 1994
  • Member of the National Academy of Sciences, 1993

Best Publications

  • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

    Martin Scheffner;Bruce A. Werness;Jon M. Huibregtse;Arnold J. Levine

  • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

    Nicholas Dyson;Peter M. Howley;Karl Münger;Ed Harlow

  • Association of human papillomavirus types 16 and 18 E6 proteins with p53.

    Bruce A. Werness;Arnold J. Levine;Peter M. Howley

  • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

    Martin Scheffner;Jon M. Huibregtse;Richard D. Vierstra;Peter M. Howley

  • The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes.

    K Münger;W C Phelps;V Bubb;P M Howley

  • Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

    K Münger;B A Werness;N Dyson;W C Phelps

  • A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

  • The Molecular Basis of Cancer

    John Mendelsohn;Peter M. Howley;Mark A. Israel;Joe W. Gray

  • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • Human papillomavirus immortalization and transformation functions.

    Karl Münger;Peter M Howley

  • The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

    Martin Scheffner;Karl Münger;Janet C. Byrne;Peter M. Howley

  • Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.

    Carl C Baker;W C Phelps;V Lindgren;M J Braun

  • Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

    Marc G Wathelet;Charles H Lin;Bhavin S Parekh;Lucienne V Ronco

  • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

    S Chellappan;V B Kraus;B Kroger;K Munger

  • In Vivo Ubiquitination and Proteasome-mediated Degradation of p53

    Carl G. Maki;Jon M. Huibregtse;Peter M. Howley

  • The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

    William C. Phelps;Carole L. Yee;Karl Münger;Peter M. Howley

  • Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

    C. Yee;Indira Krishnan-Hewlett;C. C. Baker;R. Schlegel

  • Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

    Lucienne V. Ronco;Alla Y. Karpova;Marc Vidal;Peter M. Howley

  • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53

    Jon M. Huibregtse;Martin Scheffner;Peter M. Howley

  • Correction: A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase

    Jon M. Huibregtse;Martin Scheffner;Sylvie Beaudenon;Peter M. Howley

Frequent Co-Authors

Karl Münger
Karl Münger Tufts University
Jon M. Huibregtse
Jon M. Huibregtse The University of Texas at Austin
Martin Scheffner
Martin Scheffner University of Konstanz
George Khoury
George Khoury National Institutes of Health
Malcolm A. Martin
Malcolm A. Martin National Institutes of Health
Paul F. Lambert
Paul F. Lambert University of Wisconsin–Madison
Alison A. McBride
Alison A. McBride National Institutes of Health
J. Wade Harper
J. Wade Harper Harvard Medical School
Richard Schlegel
Richard Schlegel Georgetown University Medical Center
Mathew E. Sowa
Mathew E. Sowa Harvard University

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