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Biology and Biochemistry

D-Index
44
Citations
19664
World Ranking
19186
National Ranking
7833

Overview

Mathew E. Sowa is affiliated with Harvard University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with specific work in molecular biology, computational theory and mathematics, organic chemistry, oncology, and electrical and electronic engineering.

Their scholarly contributions include research on protein degradation and inhibitors, melanoma and MAPK pathways, computational drug discovery methods, click chemistry and its applications, signaling pathways in disease, viral infectious diseases and gene expression in insects, and CAR-T cell therapy research.

Mathew E. Sowa has published in several scientific venues, frequently contributing to:

  • Cancer Research
  • Proceedings of the National Academy of Sciences
  • Current Research in Chemical Biology
  • Research and Practice in Thrombosis and Haemostasis

Their recent papers include:

  • Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface (2020, Proceedings of the National Academy of Sciences)
  • Development of an AchillesTAG degradation system and its application to control CAR-T activity (2021, Current Research in Chemical Biology)
  • Abstract 2158: Preclinical evaluation of CFT1946 as a selective degrader of mutant BRAF for the treatment of BRAF driven cancers (2022, Cancer Research)
  • Abstract 3425: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers (2023, Cancer Research)
  • Abstract ND05: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers (2023, Cancer Research)

Frequent co-authors collaborating with Mathew E. Sowa include:

  • Roy M. Pollock
  • Stewart L. Fisher
  • Joelle Baddour
  • Roman V. Agafonov
  • Joe Patel

Best Publications

  • A tissue-specific atlas of mouse protein phosphorylation and expression.

    Edward L. Huttlin;Mark P. Jedrychowski;Joshua E. Elias;Tapasree Goswami

  • Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

    Woong Kim;Eric J. Bennett;Edward L. Huttlin;Ailan Guo

  • Network organization of the human autophagy system

    Christian Behrends;Mathew E. Sowa;Steven P. Gygi;J. Wade Harper

  • Defining the Human Deubiquitinating Enzyme Interaction Landscape

    Mathew E. Sowa;Eric J. Bennett;Steven P. Gygi;J. Wade Harper

  • The BioPlex Network: A Systematic Exploration of the Human Interactome

    Edward L. Huttlin;Lily Ting;Raphael J. Bruckner;Fana Gebreab

  • Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

    Shireen A. Sarraf;Malavika Raman;Virginia Guarani-Pereira;Mathew E. Sowa

  • The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

    Shaila Rahman;Mathew E. Sowa;Matthias Ottinger;Jennifer A. Smith

  • Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

    Bing Hao;Stephanie Oehlmann;Mathew E. Sowa;J. Wade Harper

  • Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

    Jennifer M. Svendsen;Agata Smogorzewska;Agata Smogorzewska;Mathew E. Sowa;Brenda C. O'Connell

  • Defining human ERAD networks through an integrative mapping strategy.

    John C. Christianson;John C. Christianson;James A. Olzmann;Thomas A. Shaler;Mathew E. Sowa

  • The Structure of ClpB: A Molecular Chaperone that Rescues Proteins from an Aggregated State

    Sukyeong Lee;Mathew E. Sowa;Yo Hei Watanabe;Paul B. Sigler

  • Cancer Proliferation Gene Discovery Through Functional Genomics

    Michael R. Schlabach;Ji Luo;Nicole L. Solimini;Guang Hu

  • Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

    Frank Stegmeier;Michael Rape;Michael Rape;Viji M. Draviam;Viji M. Draviam;Grzegorz Nalepa

  • A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

    Agata Smogorzewska;Agata Smogorzewska;Agata Smogorzewska;Rohini Desetty;Takamune T. Saito;Michael Schlabach

  • Evolutionary predictions of binding surfaces and interactions.

    Olivier Lichtarge;Mathew E Sowa

  • A large-scale method to measure absolute protein phosphorylation stoichiometries

    Ronghu Wu;Wilhelm Haas;Noah Dephoure;Edward L Huttlin

  • Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses

    Elizabeth A. White;Mathew E. Sowa;Min Jie Alvin Tan;Sheila Jeudy

  • Structural clusters of evolutionary trace residues are statistically significant and common in proteins.

    Srinivasan Madabushi;Hui Yao;Mike Marsh;David M Kristensen

  • An Accurate, Sensitive, and Scalable Method to Identify Functional Sites in Protein Structures

    Hui Yao;David M. Kristensen;David M. Kristensen;Ivana Mihalek;Mathew E. Sowa

  • A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

    Cecilia Cotta-Ramusino;rd E. Robert McDonald;Kristen Hurov;Mathew E. Sowa

Frequent Co-Authors

J. Wade Harper
J. Wade Harper Harvard Medical School
Steven P. Gygi
Steven P. Gygi Harvard University
Stephen J. Elledge
Stephen J. Elledge Harvard University
Olivier Lichtarge
Olivier Lichtarge Baylor College of Medicine
Agata Smogorzewska
Agata Smogorzewska Rockefeller University
Yang Shi
Yang Shi University of Oxford
Theodore G. Wensel
Theodore G. Wensel Baylor College of Medicine
Peter M. Howley
Peter M. Howley Harvard Medical School
Peter K. Sorger
Peter K. Sorger Harvard University
Wilhelm Haas
Wilhelm Haas Harvard University

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