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Genetics

D-Index
59
Citations
19900
World Ranking
3203
National Ranking
1394

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Olivier Lichtarge is affiliated with Baylor College of Medicine in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a significant focus on medicine. Within these broader fields, Lichtarge's work often concentrates on molecular biology, genetics, infectious diseases, physiology, and cancer research.

The scientist's work addresses various topics, including bioinformatics and genomic networks, genomics and rare diseases, RNA and protein synthesis mechanisms, receptor mechanisms and signaling, genetic associations and epidemiology, cancer genomics and diagnostics, and CRISPR and genetic engineering.

Among the recent papers authored, several stand out by their publication year and venue:

  • Genome interpretation using in silico predictors of variant impact, 2022, Human Genetics
  • Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease, 2020, Progress in Biophysics and Molecular Biology
  • Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors, 2021, Progress in Biophysics and Molecular Biology
  • Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity, 2023, Nature Metabolism
  • Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli, 2022, Nature Communications

Lichtarge frequently collaborates with other researchers, including Panagiotis Katsonis, Amanda M. Williams, Predrag Radivojac, Thomas Bourquard, and Constantina Bakolitsa. Panagiotis Katsonis is a particularly frequent collaborator with 45 coauthored works.

The scientist's publications often appear in venues such as Human Genetics, Alzheimer's & Dementia, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, and Bioinformatics. Human Genetics is notably a prominent journal for Lichtarge with eight publications.

In 2019, Olivier Lichtarge was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

    Adrian Ally;Miruna Balasundaram;Rebecca Carlsen;Eric Chuah

  • An evolutionary trace method defines binding surfaces common to protein families

    Olivier Lichtarge;Henry R. Bourne;Fred E. Cohen

  • A large-scale evaluation of computational protein function prediction

    Predrag Radivojac;Wyatt T Clark;Tal Ronnen Oron;Alexandra M Schnoes

  • β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor

    Sudha K. Shenoy;Matthew T. Drake;Christopher D. Nelson;Daniel A. Houtz

  • Pathogenic Germline Variants in 10,389 Adult Cancers

    Kuan-Lin Huang;R Jay Mashl;Yige Wu;Deborah I Ritter

  • Identification of a candidate therapeutic autophagy-inducing peptide

    Sanae Shoji-Kawata;Rhea Sumpter;Matthew J Leveno;Grant R. Campbell;Grant R. Campbell

  • Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.

    Lawrence A. Donehower;Thierry Soussi;Anil Korkut;Yuexin Liu

  • Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

    Søren P. Sheikh;Tatyana A. Zvyaga;Olivier Lichtarge;Thomas P. Sakmar

  • The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

    Naihui Zhou;Yuxiang Jiang;Timothy R. Bergquist;Alexandra J. Lee

  • Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes

    Ruthie E. Amir;Ignatia B. Van Den Veyver;Rebecca Schultz;Denise M. Malicki

  • A family of evolution-entropy hybrid methods for ranking protein residues by importance.

    I. Mihalek;I. Reš;O. Lichtarge

  • Evolutionary predictions of binding surfaces and interactions.

    Olivier Lichtarge;Mathew E Sowa

  • Receptor and βγ Binding Sites in the α Subunit of the Retinal G Protein Transducin

    René Onrust;Paul Herzmark;Patty Chi;Pablo D. Garcia

  • Structural clusters of evolutionary trace residues are statistically significant and common in proteins.

    Srinivasan Madabushi;Hui Yao;Mike Marsh;David M Kristensen

  • An Accurate, Sensitive, and Scalable Method to Identify Functional Sites in Protein Structures

    Hui Yao;David M. Kristensen;David M. Kristensen;Ivana Mihalek;Mathew E. Sowa

  • An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders

    Steven Andrew Baker;Lin Chen;Angela Dawn Wilkins;Peng Yu

  • Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

    Abu Amar M. Al Mamun;Mary Jane Lombardo;Chandan Shee;Andreas M. Lisewski

  • Similar Structures and Shared Switch Mechanisms of the β2-Adrenoceptor and the Parathyroid Hormone Receptor Zn(II) BRIDGES BETWEEN HELICES III AND VI BLOCK ACTIVATION

    Søren P. Sheikh;Jean-Pierre Vilardarga;Thomas J. Baranski;Olivier Lichtarge

  • Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions *

    Srinivasan Madabushi;Alecia K. Gross;Anne Philippi;Elaine C. Meng

  • Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.

    Olivier Lichtarge;Henry R. Bourne;Fred E. Cohen

Frequent Co-Authors

Lydia E. Kavraki
Lydia E. Kavraki Rice University
Rita Casadio
Rita Casadio University of Bologna
Marek Kimmel
Marek Kimmel Rice University
Predrag Radivojac
Predrag Radivojac Northeastern University
Theodore G. Wensel
Theodore G. Wensel Baylor College of Medicine
Steven E. Brenner
Steven E. Brenner University of California, Berkeley
Lawrence A. Donehower
Lawrence A. Donehower Baylor College of Medicine
Sean D. Mooney
Sean D. Mooney University of Washington
John Moult
John Moult University of Maryland, College Park
David T. Jones
David T. Jones University College London

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